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Contents

        Preface: Current Topics in Molecular Diagnostics and Precision Medicine xi

        Gregory J. Tsongalis

        Syndromic and Point-of-Care Molecular Testing 507

        Ryan F. Relich and April N. Abbott

        Building Evidence for Clinical Use of Pharmacogenomics and Reimbursement for Testing 533

        Larisa H. Cavallari and Victoria M. Pratt

        Replacement of Culture with Molecular Testing for Diagnosis Infectious Diseases 547

        Gerald A. Capraro

        Next-Generation Sequencing Approaches to Predicting Antimicrobial Susceptibility Testing Results 557

        Rebecca Yee and Patricia J. Simner

        Utility of Fluorescence In Situ Hybridization in Clinical and Research Applications 573

        Gail H. Vance and Wahab A. Khan

        Precision Medicine Using Pharmacogenomic Panel-Testing: Current Status and Future Perspectives 587

        Cathelijne H. van der Wouden, Henk-Jan Guchelaar, and Jesse J. Swen

        HLA Typing by Next-Generation Sequencing: Lessons Learned and Future Applications 603

        Caleb Cornaby and Eric T. Weimer

        Applications of Noninvasive Prenatal Testing for Subchromosomal Copy Number Variations Using Cell-Free DNA 613

        Jiale Xiang and Zhiyu Peng

        The Role of the Human Gutome on Chronic Disease: A Review of the Microbiome and Nutrigenomics 627

        Carrie C. Hoefer, Leah K. Hollon, and Jennifer A. Campbell

        Blood Group Genotyping 645

        Jensyn K. Cone Sullivan, Nicholas Gleadall, and William J. Lane

        Cell-free Nucleic Acids in Cancer: Current Approaches, Challenges, and Future Directions 669

        Liron Barnea Slonim, Kathy A. Mangold, Mir B. Alikhan, Nora Joseph, Kalpana S. Reddy, Linda M. Sabatini, and Karen L. Kaul

        Review of SARS-CoV-2 Antigen and Antibody Testing in Diagnosis and Community Surveillance 687

        Robert D. Nerenz, Jacqueline A. Hubbard, and Mark A. Cervinsk