Syndromic and point-of-care molecular diagnostic testing methods have revolutionized
infectious disease testing by permitting the simultaneous detection of multiple pathogens
and drug resistance mechanisms directly from clinical specimens and positive blood
cultures.
Keywords
To read this article in full you will need to make a payment
Purchase one-time access:
Academic & Personal: 24 hour online accessCorporate R&D Professionals: 24 hour online accessOne-time access price info
- For academic or personal research use, select 'Academic and Personal'
- For corporate R&D use, select 'Corporate R&D Professionals'
Subscribers receive full online access to your subscription and archive of back issues up to and including 2002.
Content published before 2002 is available via pay-per-view purchase only.
Subscribe:
Subscribe to Clinics in Laboratory MedicineAlready a print subscriber? Claim online access
Already an online subscriber? Sign in
Register: Create an account
Institutional Access: Sign in to ScienceDirect
References
- Use of rapid, nonradioactive DNA probes in culture confirmation tests to detect Streptococcus agalactiae, Haemophilus influenza, and Enterococcus spp. from pediatric patients with significant infections.J Clin Microbiol. 1991; 29: 80-82
- Direct identification of bacterial isolates in blood cultures by using a DNA probe.J Clin Microbiol. 1991; 29: 2193-2196
- Rapid identification of mycobacteria by the Gen-Probe Accuprobe system.Pathology. 1993; 25: 313-315
- Comparative evaluation of chemilluminescent DNA probe assays and exoantigen tests for rapid identification of Blastomyces dermatitidis and Coccidioides immitis.J Clin Microbiol. 1994; 32: 867-870
- The polymerase chain reaction (PCR): a valuable method for retroviral detection.Lymphology. 1990; 23: 92-97
- Detection of Babesia microti by polymerase chain reaction.J Clin Microbiol. 1992; 30: 2097-2103
- Rapid detection of parainfluenza virus type 3 RNA in respiratory specimens: use of reverse-transcription-PCR-enzyme immunoassay.J Clin Microbiol. 1994; 32: 484-488
- Developments in quantitative PCR.Clin Chem Lab Med. 1998; 36: 255-269
- Clinical impact of multiplex syndromic panels in the diagnosis of bloodstream, gastrointestinal, respiratory, and central nervous system infections.Clin Microbiol Newsl. 2017; 39: 133-142
- Clinical impact and provider acceptability of real-time antimicrobial stewardship decision support for rapid diagnostics in children with positive blood culture results.J Pediatric Infect Dis Soc. 2016; 6: 267-274
- Impact of early detection of respiratory viruses by multiplex PCR assay on clinical outcomes in adult patients.J Clin Microbiol. 2016; 54: 2096-2103
- Performance evaluation of the Verigene® (Nanosphere) and FilmArray® (BioFire®) molecular assays for identification of causative organisms in bacterial bloodstream infections.Eur J Clin Microbiol Infect Dis. 2015; 34: 487-496
- Evaluation of the FilmArray blood culture identification panel: results of a multicenter controlled trial.J Clin Microbiol. 2016; 54: 687-698
- Profile of the triplex assay for detection of chlamydia, gonorrhea, and trichomonas using the BD MAX system.Expert Rev Mol Diagn. 2017; 17: 539-547
- Multicenter evaluation of the BD MAX enteric parasite real-time PCR assay for detection of Giardia duodenalis, Cryptosporidium hominis, Cryptosporidium parvum, and Entamoeba histolytica.J Clin Microbiol. 2016; 54: 2681-2688
- Comparison of the BD MAX enteric pathogen panel with conventional diagnostic procedures in diarrheal stool samples.Eur J Clin Microbiol Infect Dis. 2016; 35: 131-136
- Multisite evaluation of the BD MAX extended enteric bacterial panel for detection of Yersinia enterocolitica, enterotoxigenic Escherichia coli, Vibrio, and Plesiomonas shigelloides from stool specimens.J Clin Microbiol. 2017; 55: 3258-3266
- Comparison of the ePlex respiratory pathogen panel with laboratory-developed real-time PCR assays for detection of respiratory pathogens.J Clin Microbiol. 2017; 55: 1938-1945
- Comparison of the GenMark diagnostics eSensor respiratory viral panel to real-time PCR for detection of respiratory viruses in children.J Clin Microbiol. 2012; 50: 3458-3465
- Multicenter evaluation of the ePlex respiratory pathogen panel for the detection of viral and bacterial respiratory tract pathogens in nasopharyngeal swabs.J Clin Microbiol. 2018; 56 ([pii:e01658-17])
- Clinical implications of rapid ePlex respiratory pathogen panel testing compared to laboratory-developed real-time PCR.Eur J Clin Microbiol Infect Dis. 2018; 37: 571-577
- Performance of the FilmArray blood culture identification panel utilized by non-expert staff compared to conventional microbial identification and antimicrobial resistance gene detection from positive blood cultures.J Med Microbiol. 2016; 65: 619-625
- Impact of a rapid respiratory panel test on patient outcomes.Arch Pathol Lab Med. 2015; 139: 636-641
- Rapid respiratory panel testing influences patient management and clinical outcomes.MLO Med Lab Obs. 2014; 46: 16
- Benefits of adding a rapid PCR-based blood culture identification panel to an established antimicrobial stewardship program.J Clin Microbiol. 2016; 54: 2455-2463
- Implementation and performance of the BioFire FilmArray blood culture identification panel with antimicrobial treatment recommendations for bloodstream infections at a midwestern academic tertiary hospital.Diagn Microbiol Infect Dis. 2015; 81: 96-101
- Multicenter evaluation of the BioFire FilmArray gastrointestinal panel for etiologic diagnosis of infectious gastroenteritis.J Clin Microbiol. 2015; 53: 915-925
- Use of a culture-independent gastrointestinal multiplex PCR panel during a shigellosis outbreak: considerations for clinical laboratories and public health.J Clin Microbiol. 2015; 53: 1048-1049
- Preclinical assessment of a fully automated multiplex PCR panel for detection of central nervous system pathogens.J Clin Microbiol. 2016; 54: 785-787
- Economic analysis of rapid multiplex polymerase chain reaction testing for meningitis/encephalitis in pediatric patients.Future Microbiol. 2018; 13: 617-629
- Clinical evaluation of the BioFire FilmArray BioThreat-E test for the diagnosis of Ebola virus disease in Guinea.J Clin Virol. 2017; 92: 20-24
- Assessment of the multiplex PCR-based assay Unyvero pneumonia application for detection of bacterial pathogens and antibiotic resistance genes in children and neonates.Infection. 2018; 46: 189-196
- ‘Sample-in, answer-out’? Evaluation and comprehensive analysis of the Unyvero P50 pneumonia assay.Diagn Microbiol Infect Dis. 2016; 86: 5-10
- Identification of Gram-negative bacteria and genetic resistance determinants from positive blood culture broths by use of the Verigene Gram-negative blood culture multiplex microarray-based molecular assay.J Clin Microbiol. 2015; 53: 2460-2472
- Multiplex identification of Gram-positive bacteria and resistance determinants directly from positive blood culture broths: evaluation of an automated microarray-based nucleic acid test.PLoS Med. 2013; 10: e1001478
- The role of the NxTAG respiratory pathogen panel assay and other multiplex platforms in clinical practice.Expert Rev Mol Diagn. 2017; 17: 9-17
- Clinical evaluation of the Luminex NxTAG respiratory pathogen panel.J Clin Microbiol. 2016; 54: 1912-1914
- Performance of the Verigene enteric pathogens test, BioFire FilmArray gastrointestinal panel and Luminex xTAG gastrointestinal pathogen panel for detection of common enteric pathogens.Diagn Microbiol Infect Dis. 2016; 86: 336-339
- Syndromic panel-based testing in clinical microbiology.Clin Microbiol Rev. 2017; 31 ([pii:e00024-17])
- Multicenter evaluation of BioFire FilmArray Meningitis/Encephalitis Panel for detection of bacteria, viruses, and yeast in cerebrospinal fluid specimens.J Clin Microbiol. 2016; 54: 2251-2261
- Point-counterpoint: meningitis/encephalitis syndromic testing in the clinical laboratory.J Clin Microbiol. 2018; 56 ([pii:e00018-18])
- Clinical impact of a multiplex gastrointestinal PCR panel in patients with acute gastroenteritis.Clin Infect Dis. 2018; https://doi.org/10.1093/cid/ciy357
- Multicenter evaluation of BioFire FilmArray Respiratory Panel 2 for detection of viruses and bacteria in nasopharyngeal swab samples.J Clin Microbiol. 2018; 25 ([pii:e01945-17]): 56
Kawa D, Paradis S, Yu JH, et al. Evaluating the standard of care for women’s health: the BD MAX Vaginal Panel and management of vaginal infections (white paper). 2017. Available at: http://moleculardiagnostics.bd.com/wp-content/uploads/2017/08/MAX-Vaginal-Panel-Whitepaper.pdf. Accessed June 25, 2018.
- Diagnostic accuracy of the real-time PCR cobas Liat influenza A/B assay and the Alere i influenza A&B NEAR isothermal nucleic acid amplification assay for the detection of influenza using adult nasopharyngeal specimens.J Clin Virol. 2017; 94: 86-90
- Diagnostic accuracy and cost analysis of the Alere i influenza A&B near-patient test using throat swabs.J Hosp Infect. 2017; 97: 301-309
- Multicenter clinical evaluation of the Alere i respiratory syncytial virus isothermal nucleic acid amplification assay.J Clin Microbiol. 2018; 56 ([pii:e01777-17])
- Performance of the Alere i RSV assay for point-of-care detection of respiratory syncytial virus in children.BMC Infect Dis. 2017; 17: 767
- Multicenter clinical evaluation of the novel Alere i Strep A isothermal nucleic acid amplification test.J Clin Microbiol. 2015; 53: 2258-2261
- Comparison of the Alere i Strep A test and the BD Veritor system in the detection of group A Streptococcus and the hypothetical impact of results on antibiotic utilization.J Clin Microbiol. 2018; 56 ([pii:e01310-17])
- Lab-in-a-tube: real-time molecular point-of-care diagnostics for influenza A and B using the cobas Liat system.J Med Virol. 2017; 89: 1382-1386
- Multi-center evaluation of the cobas Liat Influenza A/B & RSV assay for rapid point of care diagnosis.J Clin Virol. 2017; 95: 5-9
- Parallel validation of three molecular devices for simultaneous detection and identification of influenza A and B and respiratory syncytial viruses.J Clin Microbiol. 2018; 56 ([pii:e01691-17])
- Clinical performance of the Solana point-of-care trichomonas assay from clinician-collected vaginal swabs and urine specimens from symptomatic and asymptomatic women.Expert Rev Mol Diagn. 2017; 17: 303-306
Article info
Footnotes
This article originally appeared in Advances in Molecular Pathology, Volume 1, Issue 1, November 2018.
Identification
Copyright
© 2022 Elsevier Inc. All rights reserved.
