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Review Article| Volume 41, ISSUE 1, P35-49, March 2021

Massive Transfusion in Pediatric Patients

Published:December 15, 2020DOI:https://doi.org/10.1016/j.cll.2020.10.003

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      References

        • Dzik W.H.
        • Blajchman M.A.
        • Fergusson D.
        • et al.
        Clinical review: Canadian National Advisory Committee on blood and blood products--massive transfusion consensus conference 2011: report of the panel.
        Crit Care. 2011; 15: 242
      1. Stewart RM, Nathens AB, Chang MC. 2016:128 NTDB Reports and Publications. American College of Surgeons. Available at: https://www.facs.org/quality-programs/trauma/tqp/center-programs/ntdb/docpub. Accessed May 2, 2020.

        • Edwards M.J.
        • Lustik M.
        • Eichelberger M.R.
        • et al.
        Blast injury in children: an analysis from Afghanistan and Iraq, 2002-2010.
        J Trauma Acute Care Surg. 2012; 73: 1278-1283
        • Tasker R.C.
        • Turgeon A.F.
        • Spinella P.C.
        • Pediatric critical care Transfusion and Anemia Expertise Initiative (TAXI)
        • Pediatric Critical Care Blood Research Network (BloodNet), and the Pediatric Acute Lung Injury and Sepsis Investigators (PALISI) Network
        Recommendations on RBC transfusion in critically Ill children with acute brain injury from the pediatric critical care transfusion and anemia expertise initiative.
        Pediatr Crit Care Med. 2018; 19: S133-S136
        • Paterson N.A.
        Validation of a theoretically derived model for the management of massive blood loss in pediatric patients - a case report.
        Paediatr Anaesth. 2009; 19: 535-540
        • Diab Y.A.
        • Wong E.C.C.
        • Luban N.L.C.
        Massive transfusion in children and neonates.
        Br J Haematol. 2013; 161: 15-26
        • Shroyer M.C.
        • Griffin R.L.
        • Mortellaro V.E.
        • et al.
        Massive transfusion in pediatric trauma: analysis of the National Trauma Databank.
        J Surg Res. 2017; 208: 166-172
        • Niles S.E.
        • McLaughlin D.F.
        • Perkins J.G.
        • et al.
        Increased mortality associated with the early coagulopathy of trauma in combat casualties.
        J Trauma. 2008; 64 ([discussion: 1463–5]): 1459-1463
        • Patregnani J.T.
        • Borgman M.A.
        • Maegele M.
        • et al.
        Coagulopathy and shock on admission is associated with mortality for children with traumatic injuries at combat support hospitals.
        Pediatr Crit Care Med. 2012; 13: 273-277
        • Cannon J.W.
        Hemorrhagic shock.
        N Engl J Med. 2018; 378: 370-379
        • White N.J.
        • Ward K.R.
        • Pati S.
        • et al.
        Hemorrhagic blood failure: oxygen debt, coagulopathy, and endothelial damage.
        J Trauma Acute Care Surg. 2017; 82: S41-S49
      2. Spinella PC, Trauma Hemostasis and Oxygenation Research Network. Damage control resuscitation: identification and treatment of life-threatening hemorrhage; 2020. Available at: https://www.springer.com/gp/book/9783030208196.

        • Johansson P.I.
        • Ostrowski S.R.
        Acute coagulopathy of trauma: balancing progressive catecholamine induced endothelial activation and damage by fluid phase anticoagulation.
        Med Hypotheses. 2010; 75: 564-567
        • Kozar R.A.
        • Peng Z.
        • Zhang R.
        • et al.
        Plasma restoration of endothelial glycocalyx in a rodent model of hemorrhagic shock.
        Anesth Analg. 2011; 112: 1289-1295
        • Lawless R.A.
        • Holcomb J.B.
        Plasma Transfusion.
        in: Gonzalez E. Moore H. Moore E. Trauma Induced Coagulopathy. Springer, Cham, 2016https://doi.org/10.1007/978-3-319-28308-1_20
        • Cardenas J.C.
        • Zhang X.
        • Fox E.E.
        • et al.
        Platelet transfusions improve hemostasis and survival in a substudy of the prospective, randomized PROPPR trial.
        Blood Adv. 2018; 2: 1696-1704
        • Moore H.B.
        • Moore E.E.
        • Chapman M.P.
        • et al.
        Viscoelastic measurements of platelet function, not fibrinogen function, predicts sensitivity to tissue-type plasminogen activator in trauma patients.
        J Thromb Haemost. 2015; 13: 1878-1887
        • Baimukanova G.
        • Miyazawa B.
        • Potter D.R.
        • et al.
        Platelets regulate vascular endothelial stability: assessing the storage lesion and donor variability of apheresis platelets.
        Transfusion (Paris). 2016; 56: S65-S75
        • Fries D.
        • Martini W.Z.
        Role of fibrinogen in trauma-induced coagulopathy.
        Br J Anaesth. 2010; 105: 116-121
        • Spinella P.C.
        • Perkins J.G.
        • Grathwohl K.W.
        • et al.
        Warm fresh whole blood is independently associated with improved survival for patients with combat-related traumatic injuries.
        J Trauma. 2009; 66: S69-S76
        • Shea S.M.
        • Staudt A.M.
        • Thomas K.A.
        • et al.
        The use of low-titer group O whole blood is independently associated with improved survival compared to component therapy in adults with severe traumatic hemorrhage.
        Transfusion (Paris). 2020; 60: S2-S9
        • Williams J.
        • Merutka N.
        • Meyer D.
        • et al.
        Safety profile and impact of low-titer group O whole blood for emergency use in trauma.
        J Trauma Acute Care Surg. 2020; 88: 87-93
        • Schuster K.M.
        • Davis K.A.
        • Lui F.Y.
        • et al.
        The status of massive transfusion protocols in United States trauma centers: massive transfusion or massive confusion?.
        Transfusion (Paris). 2010; 50: 1545-1551
        • Savage S.A.
        • Zarzaur B.L.
        • Croce M.A.
        • et al.
        Redefining massive transfusion when every second counts.
        J Trauma Acute Care Surg. 2013; 74 ([discussion: 400–2]): 396-400
        • Stanworth S.J.
        • Morris T.P.
        • Gaarder C.
        • et al.
        Reappraising the concept of massive transfusion in trauma.
        Crit Care. 2010; 14: R239
        • Sihler K.C.
        • Napolitano L.M.
        Massive transfusion: new insights.
        Chest. 2009; 136: 1654-1667
        • Rahbar E.
        • Fox E.E.
        • del Junco D.J.
        • et al.
        Early resuscitation intensity as a surrogate for bleeding severity and early mortality in the PROMMTT study.
        J Trauma Acute Care Surg. 2013; 75: S16-S23
        • Nosanov L.
        • Inaba K.
        • Okoye O.
        • et al.
        The impact of blood product ratios in massively transfused pediatric trauma patients.
        Am J Surg. 2013; 206: 655-660
        • Neff L.P.
        • Cannon J.W.
        • Morrison J.J.
        • et al.
        Clearly defining pediatric massive transfusion: cutting through the fog and friction with combat data.
        J Trauma Acute Care Surg. 2015; 78 ([discussion: 28–9]): 22-28
        • Horst J.
        • Leonard J.C.
        • Vogel A.
        • et al.
        A survey of US and Canadian hospitals’ paediatric massive transfusion protocol policies.
        Transfus Med. 2016; 26: 49-56
        • Cannon J.W.
        • Johnson M.A.
        • Caskey R.C.
        • et al.
        High ratio plasma resuscitation does not improve survival in pediatric trauma patients.
        J Trauma Acute Care Surg. 2017; 83: 211-217
        • Cunningham M.E.
        • Rosenfeld E.H.
        • Zhu H.
        • et al.
        A high ratio of plasma: RBC improves survival in massively transfused injured children.
        J Surg Res. 2019; 233: 213-220
        • Nunez T.C.
        • Voskresensky I.V.
        • Dossett L.A.
        • et al.
        Early prediction of massive transfusion in trauma: simple as ABC (assessment of blood consumption)?.
        J Trauma. 2009; 66: 346-352
        • Shih A.W.
        • Al Khan S.
        • Wang A.Y.-H.
        • et al.
        Systematic reviews of scores and predictors to trigger activation of massive transfusion protocols.
        J Trauma Acute Care Surg. 2019; 87: 717-729
        • Borgman M.A.
        • Maegele M.
        • Wade C.E.
        • et al.
        Pediatric trauma BIG score: predicting mortality in children after military and civilian trauma.
        Pediatrics. 2011; 127: e892-e897
        • Hendrickson J.E.
        • Shaz B.H.
        • Pereira G.
        • et al.
        Implementation of a pediatric trauma massive transfusion protocol: one institution’s experience.
        Transfusion (Paris). 2012; 52: 1228-1236
        • Dehmer J.J.
        • Adamson W.T.
        Massive transfusion and blood product use in the pediatric trauma patient.
        Semin Pediatr Surg. 2010; 19: 286-291
        • Spinella P.C.
        • Dressler A.
        • Tucci M.
        • et al.
        Survey of transfusion policies at US and Canadian children’s hospitals in 2008 and 2009.
        Transfusion (Paris). 2010; 50: 2328-2335
        • Lee A.C.
        • Reduque L.L.
        • Luban N.L.C.
        • et al.
        Transfusion-associated hyperkalemic cardiac arrest in pediatric patients receiving massive transfusion.
        Transfusion (Paris). 2014; 54: 244-254
        • Murdock A.D.
        • Berséus O.
        • Hervig T.
        • et al.
        Whole blood: the future of traumatic hemorrhagic shock resuscitation.
        Shock. 2014; 41: 62-69
        • Borgman M.A.
        • Spinella P.C.
        • Holcomb J.B.
        • et al.
        The effect of FFP:RBC ratio on morbidity and mortality in trauma patients based on transfusion prediction score.
        Vox Sang. 2011; 101: 44-54
        • Spinella P.C.
        • Wade C.E.
        • Blackbourne L.H.
        • et al.
        • Trauma Outcomes Group
        The association of blood component use ratios with the survival of massively transfused trauma patients with and without severe brain injury.
        J Trauma. 2011; 71: S343-S352
        • Cap A.P.
        • Spinella P.C.
        • Borgman M.A.
        • et al.
        Timing and location of blood product transfusion and outcomes in massively transfused combat casualties.
        J Trauma Acute Care Surg. 2012; 73: S89-S94
        • Borgman M.A.
        • Spinella P.C.
        • Perkins J.G.
        • et al.
        The ratio of blood products transfused affects mortality in patients receiving massive transfusions at a combat support hospital.
        J Trauma. 2007; 63: 805-813
        • Spinella P.C.
        • Holcomb J.B.
        Resuscitation and transfusion principles for traumatic hemorrhagic shock.
        Blood Rev. 2009; 23: 231-240
        • Holcomb J.B.
        • del Junco D.J.
        • Fox E.E.
        • et al.
        The prospective, observational, multicenter, major trauma transfusion (PROMMTT) study: comparative effectiveness of a time-varying treatment with competing risks.
        JAMA Surg. 2013; 148: 127-136
        • Holcomb J.B.
        • Tilley B.C.
        • Baraniuk S.
        • et al.
        Transfusion of plasma, platelets, and red blood cells in a 1:1:1 vs a 1:1:2 ratio and mortality in patients with severe trauma: the PROPPR randomized clinical trial.
        JAMA. 2015; 313: 471-482
        • Noland D.K.
        • Apelt N.
        • Greenwell C.
        • et al.
        Massive transfusion in pediatric trauma: an ATOMAC perspective.
        J Pediatr Surg. 2019; 54: 345-349
        • Butler E.K.
        • Mills B.M.
        • Arbabi S.
        • et al.
        Association of blood component ratios with 24-hour mortality in injured children receiving massive transfusion.
        Crit Care Med. 2019; 47: 975-983
        • Cannon J.W.
        • Neff L.P.
        • Pidcoke H.F.
        • et al.
        The evolution of pediatric transfusion practice during combat operations 2001-2013.
        J Trauma Acute Care Surg. 2018; 84: S69-S76
        • Broxton S.
        • Medeiros R.
        • Schumacher A.
        Evaluation tool for assessing a newly implemented massive transfusion protocol.
        J Trauma Nurs. 2017; 24: 164-169
        • Hwu R.S.
        • Spinella P.C.
        • Keller M.S.
        • et al.
        The effect of massive transfusion protocol implementation on pediatric trauma care.
        Transfusion (Paris). 2016; 56: 2712-2719
        • Mh Y.
        • AP C.
        • Pc S.
        Raising the standards on whole blood.
        J Trauma Acute Care Surg. 2018; 84: S14-S17
        • Spinella P.C.
        • Gurney J.
        • Yazer M.H.
        Low titer group O whole blood for prehospital hemorrhagic shock: it is an offer we cannot refuse.
        Transfusion (Paris). 2019; 59: 2177-2179
        • Leeper C.M.
        • Neal M.D.
        • Billiar T.R.
        • et al.
        Overresuscitation with plasma is associated with sustained fibrinolysis shutdown and death in pediatric traumatic brain injury.
        J Trauma Acute Care Surg. 2018; 85: 12-17
        • Leeper C.M.
        • Yazer M.H.
        • Cladis F.P.
        • et al.
        Use of uncrossmatched cold-stored whole blood in injured children with hemorrhagic shock.
        JAMA Pediatr. 2018; 172: 491-492
        • Leeper C.M.
        • Yazer M.H.
        • Cladis F.P.
        • et al.
        Cold-stored whole blood platelet function is preserved in injured children with hemorrhagic shock.
        J Trauma Acute Care Surg. 2019; 87: 49-53
        • Leeper C.
        • Yazer M.
        • Triulzi D.
        • et al.
        Whole blood is superior to component transfusion for injured children: a propensity matched analysis.
        Ann Surg. 2020; 272: 590-594
        • Shakur H.
        • Roberts I.
        • Bautista R.
        • et al.
        • CRASH-2 Trial Collaborators
        Effects of tranexamic acid on death, vascular occlusive events, and blood transfusion in trauma patients with significant haemorrhage (CRASH-2): a randomised, placebo-controlled trial.
        Lancet. 2010; 376: 23-32
        • Ramirez R.J.
        • Spinella P.C.
        • Bochicchio G.V.
        Tranexamic acid update in trauma.
        Crit Care Clin. 2017; 33: 85-99
        • Eckert M.J.
        • Wertin T.M.
        • Tyner S.D.
        • et al.
        Tranexamic acid administration to pediatric trauma patients in a combat setting: the pediatric trauma and tranexamic acid study (PED-TRAX).
        J Trauma Acute Care Surg. 2014; 77 ([discussion: 858]): 852-858
        • Thomson J.M.
        • Huynh H.H.
        • Drone H.M.
        • et al.
        Experience in an urban level 1 trauma center with tranexamic acid in pediatric trauma: a retrospective chart review.
        J Intensive Care Med. 2020; https://doi.org/10.1177/0885066619890834
        • Maeda T.
        • Michihata N.
        • Sasabuchi Y.
        • et al.
        Safety of tranexamic acid during pediatric trauma: a nationwide database study∗.
        Pediatr Crit Care Med. 2018; 19: e637
        • Ageron F.-X.
        • Gayet-Ageron A.
        • Ker K.
        • et al.
        Effect of tranexamic acid by baseline risk of death in acute bleeding patients: a meta-analysis of individual patient-level data from 28 333 patients.
        Br J Anaesth. 2020; 124: 676-683
        • Lallemand M.S.
        • Moe D.M.
        • McClellan J.M.
        • et al.
        No intravenous access, no problem: intraosseous administration of tranexamic acid is as effective as intravenous in a porcine hemorrhage model.
        J Trauma Acute Care Surg. 2018; 84: 379-385
        • Boysen S.R.
        • Pang J.M.
        • Mikler J.R.
        • et al.
        Comparison of tranexamic acid plasma concentrations when administered via intraosseous and intravenous routes.
        Am J Emerg Med. 2017; 35: 227-233
        • Boffard K.D.
        • Riou B.
        • Warren B.
        • et al.
        Recombinant factor VIIa as adjunctive therapy for bleeding control in severely injured trauma patients: two parallel randomized, placebo-controlled, double-blind clinical trials.
        J Trauma. 2005; 59 ([discussion: 15–8]): 8-15
        • Wikkelsø A.
        • Wetterslev J.
        • Møller A.M.
        • et al.
        Thromboelastography (TEG) or rotational thromboelastometry (ROTEM) to monitor haemostatic treatment in bleeding patients: a systematic review with meta-analysis and trial sequential analysis.
        Anaesthesia. 2017; 72: 519-531
        • Dias J.D.
        • Sauaia A.
        • Achneck H.E.
        • et al.
        Thromboelastography-guided therapy improves patient blood management and certain clinical outcomes in elective cardiac and liver surgery and emergency resuscitation: a systematic review and analysis.
        J Thromb Haemost. 2019; 17: 984-994
        • Gonzalez E.
        • Moore E.E.
        • Moore H.B.
        • et al.
        Goal-directed hemostatic resuscitation of trauma-induced coagulopathy: a pragmatic randomized clinical trial comparing a viscoelastic assay to conventional coagulation assays.
        Ann Surg. 2016; 263: 1051-1059
        • Kamyszek R.W.
        • Leraas H.J.
        • Reed C.
        • et al.
        Massive transfusion in the pediatric population: a systematic review and summary of best-evidence practice strategies.
        J Trauma Acute Care Surg. 2019; 86: 744-754
        • del Junco D.J.
        • Fox E.E.
        • Camp E.A.
        • et al.
        • PROMMTT Study Group
        Seven deadly sins in trauma outcomes research: an epidemiologic post mortem for major causes of bias.
        J Trauma Acute Care Surg. 2013; 75: S97-S103

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