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Review Article| Volume 41, ISSUE 1, P15-34, March 2021

Transfusion in Neonatal Patients

Review of Evidence-Based Guidelines
  • Patricia E. Zerra
    Affiliations
    Department of Pathology and Laboratory Medicine, Emory University Hospital, 1364 Clifton Road NE, Atlanta, GA 30322, USA

    Aflac Cancer and Blood Disorders Center, Children's Healthcare of Atlanta, Egleston Hospital, 1405 Clifton Rd, Atlanta, GA 30322, USA
    Search for articles by this author
  • Cassandra D. Josephson
    Correspondence
    Corresponding author. Whitehead Biomedical Research Building, 615 Michael Street, Room 105M, Atlanta, GA 30322, USA
    Affiliations
    Department of Pathology and Laboratory Medicine, Emory University Hospital, 1364 Clifton Road NE, Atlanta, GA 30322, USA

    Aflac Cancer and Blood Disorders Center, Children's Healthcare of Atlanta, Egleston Hospital, 1405 Clifton Rd, Atlanta, GA 30322, USA
    Search for articles by this author
Published:December 22, 2020DOI:https://doi.org/10.1016/j.cll.2020.10.002

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      References

        • Jacquot C.
        • Mo Y.D.
        • Luban N.L.C.
        New approaches and trials in pediatric transfusion medicine.
        Hematol Oncol Clin North Am. 2019; 33: 507-520
        • Cure P.
        • Bembea M.
        • Chou S.
        • et al.
        2016 proceedings of the National Heart, Lung, and Blood Institute's scientific priorities in pediatric transfusion medicine.
        Transfusion. 2017; 57: 1568-1581
        • Levy G.J.
        • Strauss R.G.
        • Hume H.
        • et al.
        National survey of neonatal transfusion practices: I. Red blood cell therapy.
        Pediatrics. 1993; 91: 523-529
        • Hume H.
        • Blanchette V.
        • Strauss R.G.
        • et al.
        A survey of Canadian neonatal blood transfusion practices.
        Transfus Sci. 1997; 18: 71-80
        • Fabres J.
        • Wehrli G.
        • Marques M.B.
        • et al.
        Estimating blood needs for very-low-birth-weight infants.
        Transfusion. 2006; 46: 1915-1920
        • Zubairi H.
        • Visintainer P.
        • Fleming J.
        • et al.
        Lead exposure in preterm infants receiving red blood cell transfusions.
        Pediatr Res. 2015; 77: 814-818
        • Josephson C.D.
        • Castillejo M.I.
        • Grima K.
        • et al.
        ABO-mismatched platelet transfusions: strategies to mitigate patient exposure to naturally occurring hemolytic antibodies.
        Transfus Apher Sci. 2010; 42: 83-88
        • Bednarek F.J.
        • Weisberger S.
        • Richardson D.K.
        • et al.
        Variations in blood transfusions among newborn intensive care units. SNAP II Study Group.
        J Pediatr. 1998; 133: 601-607
        • Kahn D.J.
        • Richardson D.K.
        • Billett H.H.
        Inter-NICU variation in rates and management of thrombocytopenia among very low birth-weight infants.
        J Perinatol. 2003; 23: 312-316
        • Josephson C.D.
        • Su L.L.
        • Christensen R.D.
        • et al.
        Platelet transfusion practices among neonatologists in the United States and Canada: results of a survey.
        Pediatrics. 2009; 123: 278-285
        • Cremer M.
        • Sola-Visner M.
        • Roll S.
        • et al.
        Platelet transfusions in neonates: practices in the United States vary significantly from those in Austria, Germany, and Switzerland.
        Transfusion. 2011; 51: 2634-2641
        • Orkin S.H.
        • Nathan D.G.
        Nathan and Oski's hematology of infancy and childhood.
        7th edition. Saunders/Elsevier, Philadelphia2009
        • Doyle J.J.
        The role of erythropoietin in the anemia of prematurity.
        Semin Perinatol. 1997; 21: 20-27
        • Roseff S.D.
        • Luban N.L.
        • Manno C.S.
        Guidelines for assessing appropriateness of pediatric transfusion.
        Transfusion. 2002; 42: 1398-1413
        • Oakley F.D.
        • Woods M.
        • Arnold S.
        • et al.
        Transfusion reactions in pediatric compared with adult patients: a look at rate, reaction type, and associated products.
        Transfusion. 2015; 55: 563-570
        • Vossoughi S.
        • Perez G.
        • Whitaker B.I.
        • et al.
        Analysis of pediatric adverse reactions to transfusions.
        Transfusion. 2018; 58: 60-69
        • Carroll P.D.
        • Livingston E.
        • Baer V.L.
        • et al.
        Evaluating otherwise-discarded umbilical cord blood as a source for a Neonate's complete blood cell count at various time points.
        Neonatology. 2018; 114: 82-86
        • Christensen R.D.
        • Carroll P.D.
        • Josephson C.D.
        Evidence-based advances in transfusion practice in neonatal intensive care units.
        Neonatology. 2014; 106: 245-253
        • Rabe H.
        • Gyte G.M.
        • Diaz-Rossello J.L.
        • et al.
        Effect of timing of umbilical cord clamping and other strategies to influence placental transfusion at preterm birth on maternal and infant outcomes.
        Cochrane Database Syst Rev. 2019; (CD003248)
        • Committee on Obstetric Practice
        Committee opinion no. 684: delayed umbilical cord clamping after birth.
        Obstet Gynecol. 2017; 129: e5-e10
        • Andersson O.
        • Domellof M.
        • Andersson D.
        • et al.
        Effect of delayed vs early umbilical cord clamping on iron status and neurodevelopment at age 12 months: a randomized clinical trial.
        JAMA Pediatr. 2014; 168: 547-554
        • Leslie M.S.
        • Greene J.
        • Schulkin J.
        • et al.
        Umbilical cord clamping practices of U.S. obstetricians.
        J Neonatal Perinatal Med. 2018; 11: 51-60
        • Fogarty M.
        • Osborn D.A.
        • Askie L.
        • et al.
        Delayed vs early umbilical cord clamping for preterm infants: a systematic review and meta-analysis.
        Am J Obstet Gynecol. 2018; 218: 1-18
        • Donato H.
        • Vain N.
        • Rendo P.
        • et al.
        Effect of early versus late administration of human recombinant erythropoietin on transfusion requirements in premature infants: results of a randomized, placebo-controlled, multicenter trial.
        Pediatrics. 2000; 105: 1066-1072
        • Maier R.F.
        • Obladen M.
        • Muller-Hansen I.
        • et al.
        Early treatment with erythropoietin beta ameliorates anemia and reduces transfusion requirements in infants with birth weights below 1000 g.
        J Pediatr. 2002; 141: 8-15
        • Ohls R.K.
        • Christensen R.D.
        • Kamath-Rayne B.D.
        • et al.
        A randomized, masked, placebo-controlled study of darbepoetin alfa in preterm infants.
        Pediatrics. 2013; 132: e119-e127
        • Ohls R.K.
        • Kamath-Rayne B.D.
        • Christensen R.D.
        • et al.
        Cognitive outcomes of preterm infants randomized to darbepoetin, erythropoietin, or placebo.
        Pediatrics. 2014; 133: 1023-1030
        • Juul S.E.
        • Comstock B.A.
        • Wadhawan R.
        • et al.
        A randomized trial of erythropoietin for neuroprotection in preterm infants.
        N Engl J Med. 2020; 382: 233-243
        • Juul S.E.
        • Vu P.T.
        • Comstock B.A.
        • et al.
        Effect of high-dose erythropoietin on blood transfusions in extremely low gestational age neonates: post hoc analysis of a randomized clinical trial.
        JAMA Pediatr. 2020; 174: 933-943
        • Aher S.
        • Malwatkar K.
        • Kadam S.
        Neonatal anemia.
        Semin Fetal Neonatal Med. 2008; 13: 239-247
        • Mills R.J.
        • Davies M.W.
        Enteral iron supplementation in preterm and low birth weight infants.
        Cochrane Database Syst Rev. 2012; (CD005095)
        • Patel R.M.
        • Knezevic A.
        • Yang J.
        • et al.
        Enteral iron supplementation, red blood cell transfusion, and risk of bronchopulmonary dysplasia in very-low-birth-weight infants.
        Transfusion. 2019; 59: 1675-1682
        • Ghirardello S.
        • Dusi E.
        • Cortinovis I.
        • et al.
        Effects of red blood cell transfusions on the risk of developing complications or death: an observational study of a cohort of very low birth weight infants.
        Am J Perinatol. 2017; 34: 88-95
        • Wang Y.C.
        • Chan O.W.
        • Chiang M.C.
        • et al.
        Red blood cell transfusion and clinical outcomes in extremely low birth weight preterm infants.
        Pediatr Neonatol. 2017; 58: 216-222
        • Keir A.
        • Pal S.
        • Trivella M.
        • et al.
        Adverse effects of red blood cell transfusions in neonates: a systematic review and meta-analysis.
        Transfusion. 2016; 56: 2773-2780
        • Le V.T.
        • Klebanoff M.A.
        • Talavera M.M.
        • et al.
        Transient effects of transfusion and feeding advances (volumetric and caloric) on necrotizing enterocolitis development: a case-crossover study.
        PLoS One. 2017; 12: e0179724
        • Jacob J.
        • Kamitsuka M.
        • Clark R.H.
        • et al.
        Etiologies of NICU deaths.
        Pediatrics. 2015; 135: e59-e65
        • Mohamed A.
        • Shah P.S.
        Transfusion associated necrotizing enterocolitis: a meta-analysis of observational data.
        Pediatrics. 2012; 129: 529-540
        • Patel R.M.
        • Knezevic A.
        • Shenvi N.
        • et al.
        Association of red blood cell transfusion, anemia, and necrotizing enterocolitis in very low-birth-weight infants.
        JAMA. 2016; 315: 889-897
        • Liu Z.
        • Sun X.
        • Tang J.
        • et al.
        Intestinal inflammation and tissue injury in response to heat stress and cooling treatment in mice.
        Mol Med Rep. 2011; 4: 437-443
        • De Plaen I.G.
        Inflammatory signaling in necrotizing enterocolitis.
        Clin Perinatol. 2013; 40: 109-124
        • Hunter C.J.
        • De Plaen I.G.
        Inflammatory signaling in NEC: role of NF-kappaB, cytokines and other inflammatory mediators.
        Pathophysiology. 2014; 21: 55-65
        • Maheshwari A.
        • Schelonka R.L.
        • Dimmitt R.A.
        • et al.
        Cytokines associated with necrotizing enterocolitis in extremely-low-birth-weight infants.
        Pediatr Res. 2014; 76: 100-108
        • Arthur C.M.
        • Nalbant D.
        • Feldman H.A.
        • et al.
        Anemia induces gut inflammation and injury in an animal model of preterm infants.
        Transfusion. 2019; 59: 1233-1245
        • Bassan H.
        Intracranial hemorrhage in the preterm infant: understanding it, preventing it.
        Clin Perinatol. 2009; 36 (v): 737-762
        • Baer V.L.
        • Lambert D.K.
        • Henry E.
        • et al.
        Among very-low-birth-weight neonates is red blood cell transfusion an independent risk factor for subsequently developing a severe intraventricular hemorrhage?.
        Transfusion. 2011; 51: 1170-1178
        • Baer V.L.
        • Lambert D.K.
        • Henry E.
        • et al.
        Red blood cell transfusion of preterm neonates with a Grade 1 intraventricular hemorrhage is associated with extension to a Grade 3 or 4 hemorrhage.
        Transfusion. 2011; 51: 1933-1939
        • Ballabh P.
        Intraventricular hemorrhage in premature infants: mechanism of disease.
        Pediatr Res. 2010; 67: 1-8
        • Sharp M.
        • French N.
        • McMichael J.
        • et al.
        Survival and neurodevelopmental outcomes in extremely preterm infants 22-24 weeks of gestation born in Western Australia.
        J Paediatr Child Health. 2018; 54: 188-193
        • Jarjour I.T.
        Neurodevelopmental outcome after extreme prematurity: a review of the literature.
        Pediatr Neurol. 2015; 52: 143-152
        • Franz A.P.
        • Bolat G.U.
        • Bolat H.
        • et al.
        Attention-deficit/hyperactivity disorder and very preterm/very low birth weight: a meta-analysis.
        Pediatrics. 2018; 141
        • Joseph R.M.
        • O'Shea T.M.
        • Allred E.N.
        • et al.
        Prevalence and associated features of autism spectrum disorder in extremely low gestational age newborns at age 10 years.
        Autism Res. 2017; 10: 224-232
        • Treyvaud K.
        • Ure A.
        • Doyle L.W.
        • et al.
        Psychiatric outcomes at age seven for very preterm children: rates and predictors.
        J Child Psychol Psychiatry. 2013; 54: 772-779
        • Kirpalani H.
        • Whyte R.K.
        • Andersen C.
        • et al.
        The Premature Infants in Need of Transfusion (PINT) study: a randomized, controlled trial of a restrictive (low) versus liberal (high) transfusion threshold for extremely low birth weight infants.
        J Pediatr. 2006; 149: 301-307
        • Bell E.F.
        • Strauss R.G.
        • Widness J.A.
        • et al.
        Randomized trial of liberal versus restrictive guidelines for red blood cell transfusion in preterm infants.
        Pediatrics. 2005; 115: 1685-1691
        • Franz A.R.
        • Engel C.
        • Bassler D.
        • et al.
        Effects of liberal vs restrictive transfusion thresholds on survival and neurocognitive outcomes in extremely low-birth-weight infants: the ETTNO randomized clinical trial.
        JAMA. 2020; 324: 560-570
        • Kirpalani H.
        • Bell E.F.
        • Johnson K.J.
        • et al.
        A randomized trial of higher versus lower hemoglobin thresholds for extremely low birth weight (ELBW) infants: the Transfusion of Prematures (TOP) Trial.
        (Available at:) (Accessed 29 October, 2020)
        • Mintzer J.P.
        • Parvez B.
        • Chelala M.
        • et al.
        Monitoring regional tissue oxygen extraction in neonates <1250 g helps identify transfusion thresholds independent of hematocrit.
        J Neonatal Perinatal Med. 2014; 7: 89-100
        • Luban N.L.
        • Strauss R.G.
        • Hume H.A.
        Commentary on the safety of red cells preserved in extended-storage media for neonatal transfusions.
        Transfusion. 1991; 31: 229-235
        • Fergusson D.A.
        • Hebert P.
        • Hogan D.L.
        • et al.
        Effect of fresh red blood cell transfusions on clinical outcomes in premature, very low-birth-weight infants: the ARIPI randomized trial.
        JAMA. 2012; 308: 1443-1451
        • Carson J.L.
        • Guyatt G.
        • Heddle N.M.
        • et al.
        Clinical practice guidelines from the AABB: red blood cell transfusion thresholds and storage.
        JAMA. 2016; 316: 2025-2035
        • Sesok-Pizzini D.
        • Pizzini M.A.
        Hyperkalemic cardiac arrest in pediatric patients undergoing massive transfusion: unplanned emergencies.
        Transfusion. 2014; 54: 4-7
        • Lee A.C.
        • Reduque L.L.
        • Luban N.L.
        • et al.
        Transfusion-associated hyperkalemic cardiac arrest in pediatric patients receiving massive transfusion.
        Transfusion. 2014; 54: 244-254
        • Cohn C.
        • Delaney M.
        • Johnson S.
        • et al.
        Technical manual.
        20th edition. AABB, Bethesda (MD)2020
        • Cook S.
        • Gunter J.
        • Wissel M.
        Effective use of a strategy using assigned red cell units to limit donor exposure for neonatal patients.
        Transfusion. 1993; 33: 379-383
        • Wang-Rodriguez J.
        • Mannino F.L.
        • Liu E.
        • et al.
        A novel strategy to limit blood donor exposure and blood waste in multiply transfused premature infants.
        Transfusion. 1996; 36: 64-70
        • Strauss R.G.
        Leukocyte-reduction to prevent transfusion-transmitted cytomegalovirus infections.
        Pediatr Transplant. 1999; 3: 19-22
        • Vamvakas E.C.
        Is white blood cell reduction equivalent to antibody screening in preventing transmission of cytomegalovirus by transfusion? A review of the literature and meta-analysis.
        Transfus Med Rev. 2005; 19: 181-199
        • Kekre N.
        • Tokessy M.
        • Mallick R.
        • et al.
        Is cytomegalovirus testing of blood products still needed for hematopoietic stem cell transplant recipients in the era of universal leukoreduction?.
        Biol Blood Marrow Transplant. 2013; 19: 1719-1724
        • Nash T.
        • Hoffmann S.
        • Butch S.
        • et al.
        Safety of leukoreduced, cytomegalovirus (CMV)-untested components in CMV-negative allogeneic human progenitor cell transplant recipients.
        Transfusion. 2012; 52: 2270-2272
        • Thiele T.
        • Kruger W.
        • Zimmermann K.
        • et al.
        Transmission of cytomegalovirus (CMV) infection by leukoreduced blood products not tested for CMV antibodies: a single-center prospective study in high-risk patients undergoing allogeneic hematopoietic stem cell transplantation (CME).
        Transfusion. 2011; 51: 2620-2626
        • Strauss R.G.
        Data-driven blood banking practices for neonatal RBC transfusions.
        Transfusion. 2000; 40: 1528-1540
        • Ziemann M.
        • Krueger S.
        • Maier A.B.
        • et al.
        High prevalence of cytomegalovirus DNA in plasma samples of blood donors in connection with seroconversion.
        Transfusion. 2007; 47: 1972-1983
        • Ziemann M.
        • Heuft H.G.
        • Frank K.
        • et al.
        Window period donations during primary cytomegalovirus infection and risk of transfusion-transmitted infections.
        Transfusion. 2013; 53: 1088-1094
        • Josephson C.D.
        • Caliendo A.M.
        • Easley K.A.
        • et al.
        Blood transfusion and breast milk transmission of cytomegalovirus in very low-birth-weight infants: a prospective cohort study.
        JAMA Pediatr. 2014; 168: 1054-1062
        • Delaney M.
        • Mayock D.
        • Knezevic A.
        • et al.
        Postnatal cytomegalovirus infection: a pilot comparative effectiveness study of transfusion safety using leukoreduced-only transfusion strategy.
        Transfusion. 2016; 56: 1945-1950
        • Castle V.
        • Andrew M.
        • Kelton J.
        • et al.
        Frequency and mechanism of neonatal thrombocytopenia.
        J Pediatr. 1986; 108: 749-755
        • Christensen R.D.
        • Henry E.
        • Wiedmeier S.E.
        • et al.
        Thrombocytopenia among extremely low birth weight neonates: data from a multihospital healthcare system.
        J Perinatol. 2006; 26: 348-353
        • Roberts I.A.
        • Murray N.A.
        Thrombocytopenia in the newborn.
        Curr Opin Pediatr. 2003; 15: 17-23
        • Dohner M.L.
        • Wiedmeier S.E.
        • Stoddard R.A.
        • et al.
        Very high users of platelet transfusions in the neonatal intensive care unit.
        Transfusion. 2009; 49: 869-872
        • Stanworth S.J.
        • Clarke P.
        • Watts T.
        • et al.
        Prospective, observational study of outcomes in neonates with severe thrombocytopenia.
        Pediatrics. 2009; 124: e826-e834
        • Andrew M.
        • Paes B.
        • Bowker J.
        • et al.
        Evaluation of an automated bleeding time device in the newborn.
        Am J Hematol. 1990; 35: 275-277
        • Israels S.J.
        • Cheang T.
        • McMillan-Ward E.M.
        • et al.
        Evaluation of primary hemostasis in neonates with a new in vitro platelet function analyzer.
        J Pediatr. 2001; 138: 116-119
        • Deschmann E.
        • Sola-Visner M.
        • Saxonhouse M.A.
        Primary hemostasis in neonates with thrombocytopenia.
        J Pediatr. 2014; 164: 167-172
        • Muthukumar P.
        • Venkatesh V.
        • Curley A.
        • et al.
        Severe thrombocytopenia and patterns of bleeding in neonates: results from a prospective observational study and implications for use of platelet transfusions.
        Transfus Med. 2012; 22: 338-343
        • Fustolo-Gunnink S.F.
        • Fijnvandraat K.
        • van Klaveren D.
        • et al.
        Preterm neonates benefit from low prophylactic platelet transfusion threshold despite varying risk of bleeding or death.
        Blood. 2019; 134: 2354-2360
        • Patel R.M.
        • Josephson C.
        Neonatal and pediatric platelet transfusions: current concepts and controversies.
        Curr Opin Hematol. 2019; 26: 466-472
        • Andrew M.
        • Vegh P.
        • Caco C.
        • et al.
        A randomized, controlled trial of platelet transfusions in thrombocytopenic premature infants.
        J Pediatr. 1993; 123: 285-291
        • Curley A.
        • Stanworth S.J.
        • Willoughby K.
        • et al.
        Randomized trial of platelet-transfusion thresholds in neonates.
        N Engl J Med. 2019; 380: 242-251
        • Patel R.M.
        • Josephson C.D.
        • Shenvi N.
        • et al.
        Platelet transfusions and mortality in necrotizing enterocolitis.
        Transfusion. 2019; 59: 981-988
        • Ferrer-Marin F.
        • Chavda C.
        • Lampa M.
        • et al.
        Effects of in vitro adult platelet transfusions on neonatal hemostasis.
        J Thromb Haemost. 2011; 9: 1020-1028
        • Kumar J.
        • Dutta S.
        • Sundaram V.
        • et al.
        Platelet transfusion for PDA closure in preterm infants: a randomized controlled trial.
        Pediatrics. 2019; 143
        • Sola-Visner M.C.
        Platelet transfusions in neonates - less is more.
        N Engl J Med. 2019; 380: 287-288
        • Harris S.B.
        • Josephson C.D.
        • Kost C.B.
        • et al.
        Nonfatal intravascular hemolysis in a pediatric patient after transfusion of a platelet unit with high-titer anti-A.
        Transfusion. 2007; 47: 1412-1417
        • Conway L.T.
        • Scott E.P.
        Acute hemolytic transfusion reaction due to ABO incompatible plasma in a plateletapheresis concentrate.
        Transfusion. 1984; 24: 413-414
        • Valbonesi M.
        • De Luigi M.C.
        • Lercari G.
        • et al.
        Acute intravascular hemolysis in two patients transfused with dry-platelet units obtained from the same ABO incompatible donor.
        Int J Artif Organs. 2000; 23: 642-646
        • Angiolillo A.
        • Luban N.L.
        Hemolysis following an out-of-group platelet transfusion in an 8-month-old with Langerhans cell histiocytosis.
        J Pediatr hematology/oncology. 2004; 26: 267-269
        • Davoren A.
        • Curtis B.R.
        • Aster R.H.
        • et al.
        Human platelet antigen-specific alloantibodies implicated in 1162 cases of neonatal alloimmune thrombocytopenia.
        Transfusion. 2004; 44: 1220-1225
        • Ghevaert C.
        • Campbell K.
        • Walton J.
        • et al.
        Management and outcome of 200 cases of fetomaternal alloimmune thrombocytopenia.
        Transfusion. 2007; 47: 901-910
        • Rousseau J.
        • Goldman M.
        • David M.
        HPA-5b (Bra) neonatal alloimmune thrombocytopenia in Quebec: incidence and clinical outcome in 31 cases.
        Transfusion. 2004; 44: 844-848
        • Schmidt A.E.
        • Sahai T.
        • Refaai M.A.
        • et al.
        Severe platelet transfusion refractoriness in association with antibodies against CD36.
        Lab Med. 2020; 51: 540-544
        • Burrows R.F.
        • Kelton J.G.
        Fetal thrombocytopenia and its relation to maternal thrombocytopenia.
        N Engl J Med. 1993; 329: 1463-1466
        • Knight M.
        • Pierce M.
        • Allen D.
        • et al.
        The incidence and outcomes of fetomaternal alloimmune thrombocytopenia: a UK national study using three data sources.
        Br J Haematol. 2011; 152: 460-468
        • Kamphuis M.M.
        • Paridaans N.P.
        • Porcelijn L.
        • et al.
        Incidence and consequences of neonatal alloimmune thrombocytopenia: a systematic review.
        Pediatrics. 2014; 133: 715-721
        • Calhoun D.A.
        • Christensen R.D.
        • Edstrom C.S.
        • et al.
        Consistent approaches to procedures and practices in neonatal hematology.
        Clin Perinatol. 2000; 27: 733-753
        • Althaus J.
        • Blakemore K.J.
        Fetomaternal alloimmune thrombocytopenia: the questions that still remain.
        J Matern Fetal Neonatal Med. 2007; 20: 633-637
        • Bakchoul T.
        • Bassler D.
        • Heckmann M.
        • et al.
        Management of infants born with severe neonatal alloimmune thrombocytopenia: the role of platelet transfusions and intravenous immunoglobulin.
        Transfusion. 2014; 54: 640-645
        • Kiefel V.
        • Bassler D.
        • Kroll H.
        • et al.
        Antigen-positive platelet transfusion in neonatal alloimmune thrombocytopenia (NAIT).
        Blood. 2006; 107: 3761-3763
        • Peterson J.A.
        • McFarland J.G.
        • Curtis B.R.
        • et al.
        Neonatal alloimmune thrombocytopenia: pathogenesis, diagnosis and management.
        Br J Haematol. 2013; 161: 3-14
        • Blanchette V.S.
        • Johnson J.
        • Rand M.
        The management of alloimmune neonatal thrombocytopenia.
        Best Practice and Research: Clinical Haematology. 2000; 13: 365-390
        • Puetz J.
        • Witmer C.
        • Huang Y.S.
        • et al.
        Widespread use of fresh frozen plasma in US children's hospitals despite limited evidence demonstrating a beneficial effect.
        J Pediatr. 2012; 160: 210-215.e1
        • Motta M.
        • Del Vecchio A.
        • Perrone B.
        • et al.
        Fresh frozen plasma use in the NICU: a prospective, observational, multicentred study.
        Arch Dis Child Fetal Neonatal Ed. 2014; 99: F303-F308
        • Stanworth S.J.
        • Grant Casey J.
        • Lowe D.
        • et al.
        The use of fresh-frozen plasma in England: high levels of inappropriate use in adults and children.
        Transfusion. 2011; 51: 62-70
        • Karam O.
        • Tucci M.
        • Lacroix J.
        • et al.
        International survey on plasma transfusion practices in critically ill children.
        Transfusion. 2014; 54: 1125-1132
        • Poterjoy B.S.
        • Josephson C.D.
        Platelets, frozen plasma, and cryoprecipitate: what is the clinical evidence for their use in the neonatal intensive care unit?.
        Semin Perinatol. 2009; 33: 66-74
        • Karam O.
        • Demaret P.
        • Shefler A.
        • et al.
        Indications and effects of plasma transfusions in critically ill children.
        Am J Respir Crit Care Med. 2015; 191: 1395-1402
        • O'Shaughnessy D.F.
        • Atterbury C.
        • Bolton Maggs P.
        • et al.
        Guidelines for the use of fresh-frozen plasma, cryoprecipitate and cryosupernatant.
        Br J Haematol. 2004; 126: 11-28
        • Goldenberg N.A.
        • Manco-Johnson M.J.
        Pediatric hemostasis and use of plasma components.
        Best Pract Res Clin Haematol. 2006; 19: 143-155
      1. A randomized trial comparing the effect of prophylactic intravenous fresh frozen plasma, gelatin or glucose on early mortality and morbidity in preterm babies. The Northern Neonatal Nursing Initiative [NNNI] Trial Group.
        Eur J Pediatr. 1996; 155: 580-588
        • Maw G.
        • Furyk C.
        Pediatric massive transfusion: a systematic review.
        Pediatr Emerg Care. 2018; 34: 594-598
        • Hendrickson J.E.
        • Shaz B.H.
        • Pereira G.
        • et al.
        Coagulopathy is prevalent and associated with adverse outcomes in transfused pediatric trauma patients.
        J Pediatr. 2012; 160: 204-209.e3
        • Williams M.D.
        • Chalmers E.A.
        • Gibson B.E.
        • Haemostasis and Thrombosis Task Force
        • British Committee for Standards in Haematology
        The investigation and management of neonatal haemostasis and thrombosis.
        Br J Haematol. 2002; 119: 295-309
        • Schulte R.
        • Jordan L.C.
        • Morad A.
        • et al.
        Rise in late onset vitamin K deficiency bleeding in young infants because of omission or refusal of prophylaxis at birth.
        Pediatr Neurol. 2014; 50: 564-568
        • Shearer M.J.
        Vitamin K deficiency bleeding (VKDB) in early infancy.
        Blood Rev. 2009; 23: 49-59
        • Padmanabhan A.
        • Connelly-Smith L.
        • Aqui N.
        • et al.
        Guidelines on the use of therapeutic Apheresis in clinical practice - evidence-based approach from the writing committee of the American Society for Apheresis: the eighth special issue.
        J Clin Apher. 2019; 34: 171-354
        • New H.V.
        • Stanworth S.J.
        • Engelfriet C.P.
        • et al.
        Neonatal transfusions.
        Vox Sang. 2009; 96: 62-85
        • Eaton M.P.
        • Iannoli E.M.
        Coagulation considerations for infants and children undergoing cardiopulmonary bypass.
        Paediatr Anaesth. 2011; 21: 31-42
        • Mou S.S.
        • Giroir B.P.
        • Molitor-Kirsch E.A.
        • et al.
        Fresh whole blood versus reconstituted blood for pump priming in heart surgery in infants.
        N Engl J Med. 2004; 351: 1635-1644
        • Gruenwald C.E.
        • McCrindle B.W.
        • Crawford-Lean L.
        • et al.
        Reconstituted fresh whole blood improves clinical outcomes compared with stored component blood therapy for neonates undergoing cardiopulmonary bypass for cardiac surgery: a randomized controlled trial.
        J Thorac Cardiovasc Surg. 2008; 136: 1442-1449
        • Miao X.
        • Liu J.
        • Zhao M.
        • et al.
        Evidence-based use of FFP: the influence of a priming strategy without FFP during CPB on postoperative coagulation and recovery in pediatric patients.
        Perfusion. 2015; 30: 140-147
        • Miao X.
        • Liu J.
        • Zhao M.
        • et al.
        The influence of cardiopulmonary bypass priming without FFP on postoperative coagulation and recovery in pediatric patients with cyanotic congenital heart disease.
        Eur J Pediatr. 2014; 173: 1437-1443
        • Christensen R.D.
        • Baer V.L.
        • Lambert D.K.
        • et al.
        Reference intervals for common coagulation tests of preterm infants (CME).
        Transfusion. 2014; 54 ([quiz: 626]): 627-632
        • Naderi M.
        • Tabibian S.
        • Alizadeh S.
        • et al.
        Congenital factor V deficiency: comparison of the severity of clinical presentations among patients with rare bleeding disorders.
        Acta Haematol. 2015; 133: 148-154
        • Huang J.N.
        • Koerper M.A.
        Factor V deficiency: a concise review.
        Haemophilia. 2008; 14: 1164-1169