Keywords
To read this article in full you will need to make a payment
Purchase one-time access:
Academic & Personal: 24 hour online accessCorporate R&D Professionals: 24 hour online accessOne-time access price info
- For academic or personal research use, select 'Academic and Personal'
- For corporate R&D use, select 'Corporate R&D Professionals'
Subscribers receive full online access to your subscription and archive of back issues up to and including 2002.
Content published before 2002 is available via pay-per-view purchase only.
Subscribe:
Subscribe to Clinics in Laboratory MedicineAlready a print subscriber? Claim online access
Already an online subscriber? Sign in
Register: Create an account
Institutional Access: Sign in to ScienceDirect
References
- Intrathymic and extrathymic clonal deletion of T cells.Curr Opin Immunol. 1995; 7: 196-205
- Dysregulation of immune homeostasis in autoimmune diseases.Nat Med. 2012; 18: 42
- Regulatory T cells and immune tolerance.Cell. 2008; 133: 775-787
- Suppressor T cells.J Immunol. 1972; 108: 586
- Thyroiditis in T cell-depleted rats. Influence of strain, radiation dose, adjuvants and antilymphocyte serum.Clin Exp Immunol. 1975; 21: 362-375
- Thyroiditis in T cell-depleted rats: suppression of the autoallergic response by reconstitution with normal lymphoid cells.Clin Exp Immunol. 1976; 25: 6-16
- Study on cellular events in post-thymectomy autoimmune oophoritis in mice. II. Requirement of Lyt-1 cells in normal female mice for the prevention of oophoritis.J Exp Med. 1982; 156: 1577-1586
- Organ-specific autoimmune diseases induced in mice by elimination of T cell subset. I. Evidence for the active participation of T cells in natural self-tolerance; deficit of a T cell subset as a possible cause of autoimmune disease.J Exp Med. 1985; 161: 72-87
- Immunologic self-tolerance maintained by activated T cells expressing IL-2 receptor alpha-chains (CD25). Breakdown of a single mechanism of self-tolerance causes various autoimmune diseases.J Immunol. 1995; 155: 1151-1164
- Role of Treg in immune regulation of allergic diseases.Eur J Immunol. 2010; 40: 1232-1240
- Regulatory T-cell suppressor program co-opts transcription factor IRF4 to control T(H)2 responses.Nature. 2009; 458: 351-356
- Dynamic expression of transcription factors T-bet and GATA-3 by regulatory T cells maintains immunotolerance.Nat Immunol. 2015; 16: 197-206
- The origin of FOXP3-expressing CD4+ regulatory T cells: thymus or periphery.J Clin Invest. 2003; 112: 1310-1312
- Control of regulatory T cell development by the transcription factor Foxp3.Science. 2003; 299: 1057-1061
- Phenotypic complexity of the human regulatory T cell compartment revealed by mass cytometry.J Immunol. 2015; 195: 2030-2037
- FOXP3(+) treg cells and gender bias in autoimmune diseases.Front Immunol. 2015; 6: 493
- The importance of regulatory T-cell heterogeneity in maintaining self-tolerance.Immunol Rev. 2014; 259: 103-114
- Altering the distribution of Foxp3(+) regulatory T cells results in tissue-specific inflammatory disease.J Exp Med. 2007; 204: 1335-1347
- CCL25 mediates the localization of recently activated CD8αβ+ lymphocytes to the small-intestinal mucosa.J Clin Invest. 2002; 110: 1113-1121
- Role of alpha 4-integrins in lymphocyte homing to mucosal tissues in vivo.J Immunol. 1994; 152: 3282
- FoxP3+ T cells undergo conventional first switch to lymphoid tissue homing receptors in thymus but accelerated second switch to nonlymphoid tissue homing receptors in secondary lymphoid tissues.J Immunol. 2006; 178: 301-311
- Developmental stage, phenotype, and migration distinguish naive- and effector/memory-like CD4+ regulatory T cells.J Exp Med. 2004; 199: 303-313
- Characterization of mouse CD4 T cell subsets defined by expression of KLRG1.Eur J Immunol. 2007; 37: 3445-3454
- A requisite role for induced regulatory T cells in tolerance based on expanding antigen receptor diversity.Immunity. 2011; 35: 109-122
- Natural and adaptive foxp3+ regulatory T cells: more of the same or a division of labor?.Immunity. 2009; 30: 626-635
- Tumor evasion of the immune system by converting CD4+CD25- T cells into CD4+CD25+ T regulatory cells: role of tumor-derived TGF-.J Immunol. 2007; 178: 2883-2892
- Extrathymically generated regulatory T cells control mucosal TH2 inflammation.Nature. 2012; 482: 395-399
- Instability of the transcription factor Foxp3 leads to the generation of pathogenic memory T cells in vivo.Nat Immunol. 2009; 10: 1000-1007
- Tissue resident regulatory T cells: novel therapeutic targets for human disease.Cell Mol Immunol. 2015; 12: 543-552
- Selection of the T cell repertoire.Annu Rev Immunol. 1999; 17: 829-874
- Thymic selection of CD4+CD25+ regulatory T cells induced by an agonist self-peptide.Nat Immunol. 2001; 2: 301-306
- Application of IL-2 therapy to target T regulatory cell function.Trends Immunol. 2012; 33: 626-632
- A function for interleukin 2 in Foxp3-expressing regulatory T cells.Nat Immunol. 2005; 6: 1142-1151
- IL-2 receptor -dependent STAT5 activation is required for the development of Foxp3+ regulatory T cells.J Immunol. 2006; 178: 280-290
- Transforming growth factor-beta signaling curbs thymic negative selection promoting regulatory T cell development.Immunity. 2010; 32: 642-653
- Linked T cell receptor and cytokine signaling govern the development of the regulatory T cell repertoire.Immunity. 2008; 28: 112-121
- A two-step process for thymic regulatory T cell development.Immunity. 2008; 28: 100-111
- The transcription factor T-bet controls regulatory T cell homeostasis and function during type 1 inflammation.Nat Immunol. 2009; 10: 595-602
- Conversion of peripheral CD4+CD25- naive T cells to CD4+CD25+ regulatory T cells by TGF-beta induction of transcription factor Foxp3.J Exp Med. 2003; 198: 1875-1886
- TGF-beta1 maintains suppressor function and Foxp3 expression in CD4+CD25+ regulatory T cells.J Exp Med. 2005; 201: 1061-1067
- Cutting edge: IL-2 is essential for TGF- -mediated induction of Foxp3+ T regulatory cells.J Immunol. 2007; 178: 4022-4026
- Foxp3 in control of the regulatory T cell lineage.Nat Immunol. 2007; 8: 457-462
- Regulatory T cell development in the absence of functional Foxp3.Nat Immunol. 2007; 8: 359-368
- Epigenetic and transcriptional control of Foxp3+ regulatory T cells.Semin Immunol. 2015; 27: 10-18
- T cell receptor stimulation-induced epigenetic changes and Foxp3 expression are independent and complementary events required for Treg cell development.Immunity. 2012; 37: 785-799
- CD4+CD25+ immunoregulatory T cells suppress polyclonal T cell activation in vitro by inhibiting interleukin 2 production.J Exp Med. 1998; 188: 287-296
- Cyclic adenosine monophosphate is a key component of regulatory T cell-mediated suppression.J Exp Med. 2007; 204: 1303-1310
- Cutting edge: contact-mediated suppression by CD4+CD25+ regulatory cells involves a granzyme B-dependent, perforin-independent mechanism.J Immunol. 2005; 174: 1783-1786
- Human T regulatory cells can use the perforin pathway to cause autologous target cell death.Immunity. 2004; 21: 589-601
- CD4+CD25+Foxp3+ regulatory T cells induce cytokine deprivation-mediated apoptosis of effector CD4+ T cells.Nat Immunol. 2007; 8: 1353-1362
- CTLA-4 control over Foxp3+ regulatory T cell function.Science. 2008; 322: 271-275
- Regulatory T cells: mechanisms of differentiation and function.Annu Rev Immunol. 2012; 30: 531-564
- First-in-man clinical results of the treatment of patients with graft versus host disease with human ex vivo expanded CD4+CD25+CD127− T regulatory cells.Clin Immunol. 2009; 133: 22-26
- Infusion of ex vivo expanded T regulatory cells in adults transplanted with umbilical cord blood: safety profile and detection kinetics.Blood. 2011; 117: 1061
- Immunoselection and clinical use of T regulatory cells in HLA-haploidentical stem cell transplantation.Best Pract Res Clin Haematol. 2011; 24: 459-466
- Administration of CD4+CD25highCD127- regulatory T cells preserves β-cell function in type 1 diabetes in children.Diabetes Care. 2012; 35: 1817
- Therapy of type 1 diabetes with CD4(+)CD25(high)CD127-regulatory T cells prolongs survival of pancreatic islets - results of one year follow-up.Clin Immunol. 2014; 153: 23-30
- Human regulatory T cells undergo self-inflicted damage via granzyme pathways upon activation.JCI Insight. 2017; 2 ([pii:91599])
- The role of interleukin-2 during homeostasis and activation of the immune system.Nat Rev Immunol. 2012; 12: 180-190
- IL-2 administration increases CD4+ CD25(hi) Foxp3+ regulatory T cells in cancer patients.Blood. 2006; 107: 2409-2414
- Regulatory T-cell responses to low-dose interleukin-2 in HCV-induced vasculitis.N Engl J Med. 2011; 365: 2067-2077
- Interleukin-2 and regulatory T cells in graft-versus-host disease.N Engl J Med. 2011; 365: 2055-2066
- Low-dose interleukin-2 therapy restores regulatory T cell homeostasis in patients with chronic graft-versus-host disease.Sci Transl Med. 2013; 5: 179ra43
- Ultra low-dose IL-2 for GVHD prophylaxis after allogeneic hematopoietic stem cell transplantation mediates expansion of regulatory T cells without diminishing antiviral and antileukemic activity.Clin Cancer Res. 2014; 20: 2215-2225
- Efficacy, durability, and response predictors of low-dose interleukin-2 therapy for chronic graft-versus-host disease.Blood. 2016; 128: 130-137
- Therapeutic potential of low-dose IL-2 in a chronic GVHD patient by in vivo expansion of regulatory T cells.Cytokine. 2016; 78: 22-26
- Effects of low-dose recombinant interleukin 2 to promote t-regulatory cells in alopecia areata.JAMA Dermatol. 2014; 150: 748-751
- Low-dose interleukin-2 treatment selectively modulates CD4(+) T cell subsets in patients with systemic lupus erythematosus.Nat Med. 2016; 22: 991-993
- Adoptive transfer of allogeneic regulatory T cells into patients with chronic graft-versus-host disease.Cytotherapy. 2015; 17: 473-486
Article info
Publication history
Published online: December 19, 2018
Footnotes
Disclosure: The authors have nothing to disclose.
Identification
Copyright
© 2018 Elsevier Inc. All rights reserved.