Keywords
To read this article in full you will need to make a payment
Purchase one-time access:
Academic & Personal: 24 hour online accessCorporate R&D Professionals: 24 hour online accessOne-time access price info
- For academic or personal research use, select 'Academic and Personal'
- For corporate R&D use, select 'Corporate R&D Professionals'
Subscribers receive full online access to your subscription and archive of back issues up to and including 2002.
Content published before 2002 is available via pay-per-view purchase only.
Subscribe:
Subscribe to Clinics in Laboratory MedicineAlready a print subscriber? Claim online access
Already an online subscriber? Sign in
Register: Create an account
Institutional Access: Sign in to ScienceDirect
References
- The registry of the International Society for Heart and Lung Transplantation: thirty-fourth adult heart transplantation report-2017; focus theme: allograft ischemic time.J Hear Lung Transplant. 2017; 36: 1037-1046
- How nutrition and the maternal microbiota shape the neonatal immune system.Nat Rev Immunol. 2017; 17: 508-517
- Role of TLRs and DAMPs in allograft inflammation and transplant outcomes.Nat Rev Nephrol. 2016; 12: 281-290
- Role of TNFα in early chemokine production and leukocyte infiltration into heart allografts.Am J Transplant. 2010; 10: 59-68
- High renal ischemia temperature increases neutrophil chemoattractant production and tissue injury during reperfusion without an identifiable role for CD4 T cells in the injury.Transpl Immunol. 2009; 22: 62-71
- IL-1 receptor signaling on graft parenchymal cells regulates memory and de novo donor-reactive CD8 T cell responses to cardiac allografts.J Immunol. 2016; 196: 2827-2837
- Endogenous memory CD8 T cells are activated within cardiac allografts without mediating rejection.Am J Transplant. 2013; 13: 2293-2307
- Neutrophil mediated smooth muscle cell loss precedes allograft vasculopathy.J Cardiothorac Surg. 2010; 5: 52
- Neutrophils are responsible for impaired medial smooth muscle cell recovery and exaggerated allograft vasculopathy in aortic allografts exposed to prolonged cold ischemia.J Hear Lung Transplant. 2013; 32: 360-367
- Natural killer cells play a critical role in cardiac allograft vasculopathy in an interleukin-6–dependent manner.Transplantation. 2014; 98: 1029-1039
- Comparative analysis of dendritic cell density and total number in commonly transplanted organs: morphometric estimation in normal mice.Transpl Immunol. 2000; 8: 49-56
- Systemic transmigration of allosensitizing donor dendritic cells to host secondary lymphoid organs after rat liver transplantation.Hepatology. 2008; 47: 1352-1362
- Visualizing the innate and adaptive immune responses underlying allograft rejection by two-photon microscopy.Nat Med. 2011; 17: 744-749
- Human cytotoxic T lymphocytes. I. Limiting-dilution analysis of alloreactive cytotoxic T-lymphocyte precursor frequencies.Scand J Immunol. 1985; 22: 329-335
- A novel pathway of alloantigen presentation by dendritic cells.J Immunol. 2004; 173: 4828-4837
- Endogenous memory CD8 T cells directly mediate cardiac allograft rejection.Am J Transplant. 2014; 14: 568-579
- LFA-1 antagonism inhibits early infiltration of endogenous memory CD8 T Cells into cardiac allografts and donor-reactive T cell priming.Am J Transplant. 2011; 11: 923-935
- Cognate antigen directs CD8+ T cell migration to vascularized transplants.J Clin Invest. 2013; 123: 2663-2671
- IFN-γ production by memory helper T cells is required for CD40-independent alloantibody responses.J Immunol. 2015; 194: 1347-1356
- Antibody mediated rejection is associated with worse outcome than acute cellular rejection after pediatric heart transplant.J Hear Lung Transplant. 2016; 35: S413
- Immunosuppressive medications.Clin J Am Soc Nephrol. 2016; 11: 332-343
- Regulatory immune cells in transplantation.Nat Rev Immunol. 2012; 12: 417-430
- Critical influence of natural regulatory CD25+ T cells on the fate of allografts in the absence of immunosuppression.Transplantation. 2005; 79: 648-654
- Tregs expanded in vivo by TNFRSF25 agonists promote cardiac allograft survival.Transplantation. 2012; 94: 569-574
- Distinct inflammatory signals have physiologically divergent effects on epigenetic regulation of Foxp3 expression and Treg function.Am J Transplant. 2011; 11: 203-214
- Regulatory T cells can prevent memory CD8 + T-cell-mediated rejection following polymorphonuclear cell depletion.Eur J Immunol. 2010; 40: 3107-3116
- Alloantigen-presenting plasmacytoid dendritic cells mediate tolerance to vascularized grafts.Nat Immunol. 2006; 7: 652-662
- Myeloid-derived suppressor cells accumulate in kidney allograft tolerance and specifically suppress effector T cell expansion.J Immunol. 2008; 180: 7898-7906
- “Alternatively Activated” dendritic cells preferentially secrete IL-10, expand Foxp3+CD4+ T cells, and induce long-term organ allograft survival in combination with CTLA4-Ig.J Immunol. 2006; 177: 5868-5877
- Host-gut microbiota metabolic interactions.Science. 2012; 336: 1262-1267
- Gut microbiota, metabolites and host immunity.Nat Rev Immunol. 2016; 16: 341-352
- Characterization of the diversity and temporal stability of bacterial communities in human milk.PLoS One. 2011; 6: 1-8
- Is amniotic fluid of women with uncomplicated term pregnancies free of bacteria?.Am J Obstet Gynecol. 2018; 219: 289.e1-e12
- The gut microbial metabolite trimethylamine-N-oxide is present in human cerebrospinal fluid.Nutrients. 2017; 9: 2-5
- From hype to hope: the gut microbiota in enteric infectious disease.Cell. 2015; 163: 1326-1332
- Microbiota at the crossroads of autoimmunity.Autoimmun Rev. 2016; 15: 859-869
- Antibiotic-induced alterations of the murine gut microbiota and subsequent effects on colonization resistance against clostridium difficile.MBio. 2015; 6: 1-10
- The gut microbiota plays a protective role in the host defence against pneumococcal pneumonia.Gut. 2016; 65: 575-583
- Recognition of peptidoglycan from the microbiota by Nod1 enhances systemic innate immunity.Nat Med. 2010; 16: 228-231
- Transient TLR activation restores inflammatory response and ability to control pulmonary bacterial infection in germfree mice.J Immunol. 2012; 188: 1411-1420
- An enteric virus can replace the beneficial function of commensal bacteria.Nature. 2014; 516: 94-98
- Helicobacter pylori-derived neutrophil-activating protein increases the lifespan of monocytes and neutrophils.Cell Microbiol. 2010; 12: 754-764
- TLR5-mediated sensing of gut microbiota is necessary for antibody responses to seasonal influenza vaccination.Immunity. 2014; 41: 478-492
- The spectrum and regulatory landscape of intestinal innate lymphoid cells are shaped by the microbiome.Cell. 2016; 166: 1231-1246.e13
- Innate lymphoid cells promote anatomical containment of lymphoid-resident commensal bacteria.Science. 2012; 336: 1321-1325
- Dysbiosis contributes to arthritis development via activation of autoreactive T cells in the intestine.Arthritis Rheumatol. 2016; 68: 2646-2661
- Gut microbiota from multiple sclerosis patients enables spontaneous autoimmune encephalomyelitis in mice.Proc Natl Acad Sci U S A. 2017; 11: 201711233
- Dysbiosis in the gut microbiota of patients with multiple sclerosis, with a striking depletion of species belonging to clostridia XIVa and IV clusters.PLoS One. 2015; 10: 1-16
- Nod2: a key regulator linking microbiota to intestinal mucosal immunity.J Mol Med. 2012; 90: 15-24
- Effect of TLR agonists on the differentiation and function of human monocytic myeloid-derived suppressor cells.J Immunol. 2015; 194: 4215-4221
- Microbiota promotes systemic T-cell survival through suppression of an apoptotic factor.Proc Natl Acad Sci U S A. 2017; 114: 5497-5502
- Association of NOD2 leucine-rich repeat variants with susceptibility to Crohn’s disease.Nature. 2001; 411: 599-603
- Specific microbiota direct the differentiation of IL-17-producing T-helper cells in the mucosa of the small intestine.Cell Host Microbe. 2008; 4: 337-349
- Proinflammatory T-cell responses to gut microbiota promote experimental autoimmune encephalomyelitis.Proc Natl Acad Sci U S A. 2011; 108: 4615-4622
- Gut dysbiosis breaks immunological tolerance toward the central nervous system during young adulthood.Proc Natl Acad Sci U S A. 2017; 114: E9318-E9327
- Gender bias in autoimmunity is influenced by microbiota.Immunity. 2013; 39: 400-412
- Protective major histocompatibility complex allele prevents type 1 diabetes by shaping the intestinal microbiota early in ontogeny.Proc Natl Acad Sci U S A. 2017; 114: 9671-9676
- Treg induction by a rationally selected mixture of Clostridia strains from the human microbiota.Nature. 2013; 500: 232-236
- Induction of colonic regulatory T cells by indigenous clostridium species.Science. 2011; 331: 337-341
- Characterization of the 17 strains of regulatory T cell-inducing human-derived Clostridia.Gut Microbes. 2014; 5: 333-339
- Intestine-derived Clostridium leptum induces murine tolerogenic dendritic cells and regulatory T cells in vitro.Hum Immunol. 2014; 75: 1232-1238
- Effect of oral feeding with Clostridium leptum on regulatory T-cell responses and allergic airway inflammation in mice.Ann Allergy Asthma Immunol. 2012; 109: 201-207
- Maternal short-chain fatty acids are associated with metabolic parameters in mothers and newborns.Transl Res. 2014; 164: 153-157
- Short-chain fatty acids induce both effector and regulatory T cells by suppression of histone deacetylases and regulation of the mTOR–S6K pathway.Mucosal Immunol. 2015; 8: 80-93
- Dietary fiber and bacterial SCFA enhance oral tolerance and protect against food allergy through diverse cellular pathways.Cell Rep. 2016; 15: 2809-2824
- Evidence that asthma is a developmental origin disease influenced by maternal diet and bacterial metabolites.Nat Commun. 2015; 6: 7320
- Metabolite-sensing receptors GPR43 and GPR109A facilitate dietary fibre-induced gut homeostasis through regulation of the inflammasome.Nat Commun. 2015; 6: 1-15
- The microbial metabolites, short-chain fatty acids, regulate colonic treg cell homeostasis.Science. 2013; 341: 569-573
- The microbial metabolite butyrate regulates intestinal macrophage function via histone deacetylase inhibition.Proc Natl Acad Sci U S A. 2014; 111: 2247-2252
- Maternal treatment with short-chain fatty acids modulates the intestinal microbiota and immunity and ameliorates type 1 diabetes in the offspring.PLoS One. 2017; 12 (Mounier C, ed): e0183786
- G protein-coupled receptor 43 modulates neutrophil recruitment during acute inflammation.PLoS One. 2016; 11: 1-15
- Regulation of inflammatory responses by gut microbiota and chemoattractant receptor GPR43.Nature. 2009; 461: 1282-1286
- A role for gut microbiota and the metabolite-sensing receptor GPR43 in a murine model of gout.Arthritis Rheumatol. 2015; 67: 1646-1656
- Inducible Foxp3+ regulatory T-cell development by a commensal bacterium of the intestinal microbiota.Proc Natl Acad Sci U S A. 2010; 107: 12204-12209
- An immunomodulatory molecule of symbiotic bacteria directs maturation of the host immune system.Cell. 2005; 122: 107-118
- Polysaccharide processing and presentation by the MHCII pathway.Cell. 2004; 117: 677-687
- A commensal symbiotic factor derived from Bacteroides fragilis promotes human CD39 + Foxp3 + T cells and T reg function.Gut Microbes. 2015; 6: 234-242
- Central nervous system demyelinating disease protection by the human commensal bacteroides fragilis depends on polysaccharide a expression.J Immunol. 2010; 185: 4101-4108
- Antibiotics in neonatal life increase murine susceptibility to experimental psoriasis.Nat Commun. 2015; 6: 8424
- Commensal bacteria-derived signals regulate basophil hematopoiesis and allergic inflammation.Nat Med. 2012; 18: 538-546
- Perinatal antibiotic treatment affects murine microbiota, immune responses and allergic asthma.Gut Microbes. 2013; 4: 158-164
- Perinatal antibiotic-induced shifts in gut microbiota have differential effects on inflammatory lung diseases.J Allergy Clin Immunol. 2015; 135: 100-109.e5
- Maternal antibiotic treatment impacts development of the neonatal intestinal microbiome and antiviral immunity.J Immunol. 2016; 196: 3768-3779
- Antibiotics, birth mode, and diet shape microbiome maturation during early life.Sci Transl Med. 2016; 8: 1-14
- Early infancy microbial and metabolic alterations affect risk of childhood asthma.Sci Transl Med. 2015; 7: 307ra152
- Regulation of intestinal inflammation by microbiota following allogeneic bone marrow transplantation.J Exp Med. 2012; 209: 903-911
- Influence of donor microbiota on the severity of experimental graft-versus-host-disease.Biol Blood Marrow Transplant. 2013; 19: 164-168
- Associations between acute gastrointestinal GvHD and the baseline gut microbiota of allogeneic hematopoietic stem cell transplant recipients and donors.Bone Marrow Transplant. 2017; 52: 1643-1650
- Impact of choice, timing, sequence and combination of broad-spectrum antibiotics on the outcome of allogeneic haematopoietic stem cell transplantation.Bone Marrow Transplant. 2017; 53: 52-57
- Gut microbiome–derived metabolites modulate intestinal epithelial cell damage and mitigate graft-versus-host disease.Nat Immunol. 2016; 17: 505-513
- Antibiotic exposure and reduced short chain fatty acid production after hematopoietic stem cell transplant.Biol Blood Marrow Transplant. 2018; https://doi.org/10.1016/j.bbmt.2018.07.030
- Human microbiota characterization in the course of renal transplantation.Am J Transplant. 2014; 14: 416-427
- Gut microbial community structure and complications after kidney transplantation: a pilot study.Transplantation. 2014; 98: 697-705
Lee JR, Muthukumar T, Dadhania D, et al. Gut microbiota and tacrolimus dosing in kidney transplantation. Stepkowski S, ed. PLoS One. 2015;10(3):e0122399.
- Immunosuppressive effect of the gut microbiome altered by high-dose tacrolimus in mice.Am J Transplant. 2018; 18: 1646-1656
- The composition of the microbiota modulates allograft rejection.J Clin Invest. 2016; 126: 2736-2744
- Diversity of gut microflora is required for the generation of B cell with regulatory properties in a skin graft model.Sci Rep. 2015; 5: 1-12
- Disruption of the gut microbiota with antibiotics exacerbates acute vascular rejection.Transplantation. 2018; 102: 1085-1095
Article info
Publication history
Published online: December 17, 2018
Footnotes
Funding: This work was funded by a grant from the Heart and Stroke Foundation of Canada (J.C. Choy). J.C. Choy is the recipient of a Michael Smith Foundation for Health Research Scholar award.
Disclosures: The authors have nothing to disclose.
Identification
Copyright
© 2018 Elsevier Inc. All rights reserved.
