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Research Article| Volume 1, ISSUE 3, P559-579, September 1981

Therapeutic Drug Monitoring of Theophylline, Salicylates, and Acetaminophen

  • Frederick A. Smith
    Correspondence
    Corresponding author: Department of Pathology, Children’s Memorial Hospital, 2300 Children’s Plaza, Chicago, Illinois 60614
    Affiliations
    Assistant Professor, Department of Pathology, Northwestern University School of Medicine; Director of Clinical Chemistry, Children’s Memorial Hospital, Chicago, Illinois

    Formerly, Chief Resident, Department of Pathology, Georgetown University School of Medicine, Washington, D. C.
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      Theophylline and salicylates, drugs that are frequently prescribed for pediatric patients, have a well-defined range of optimal therapeutic concentration; therapeutic monitoring of these agents is accurate and specific. In contrast, despite the widespread use of acetaminophen, its therapeutic range is not well established; however, serious toxicity from overdose is predictable from the serum concentration.
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