Research Article| Volume 1, ISSUE 4, P631-645, December 1981


  • R.K. Chandra
    Corresponding author: Janeway Child Health Center, St. John’s, Newfoundland AIA 1R8, Canada
    Professor of Pediatric Research, Department of Pediatrics, Memorial University of Newfoundland, St. John’s, Newfoundland, Canada

    Associate Program Director and Visiting Professor of Nutrition and Immunology, Clinical Research Center, Massachusetts Institute of Technology, Cambridge, Massachusetts
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      Compromised immunity is often associated with nutritional deficiency and may be an important factor contributing to susceptibility to frequent, severe infection. Although many questions remain and the specificity of tests of immunocompetence is debatable, recent studies have documented the usefulness of employing immunocompetence as a functional measure of nutrition.
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        • Bistrian B.R.
        • Blackburn G.L.
        • Scrimshaw N.S.
        • et al.
        Cellular immunity in semistarved states in hospitalized adults.
        Am. J. Clin. Nutr. 1975; 28: 1148
        • Chandra R.K.
        Immunocompetence in undernutrition.
        J. Pediatr. 1972; 81: 1194
        • Chandra R.K.
        Rosette-forming T lymphocytes and cell-mediated immunity in malnutrition.
        Brit. Med. J. 1974; 3: 608
        • Chandra R.K.
        Reduced secretory antibody response to live attenuated measles and poliovirus vaccines in malnourished children.
        Brit. Med. J. 1975; 2: 583
        • Chandra R.K.
        Serum complement and immunoconglutinin in malnutrition.
        Arch. Dis. Child. 1975; 50: 225
        • Chandra R.K.
        Lymphocyte subpopulations in malnutrition. Cytotoxic and suppressor cells.
        Pediatrics. 1977; 59: 423
        • Chandra R.K.
        T and B lymphocyte subpopulations and leukocyte terminal deoxynucleotidyl transferase in energy-protein malnutrition.
        Acta Paediatr. Scand. 1979; 68: 841
        • Chandra R.K.
        Serum thymic hormone activity in protein-energy malnutrition.
        Clin. Exper. Immunol. 1979; 33: 228
        • Chandra R.K.
        Immunology of Nutritional Disorders.
        Arnold, London1980
        • Chandra R.K.
        Immunocompetence is a functional index of nutritional status.
        Brit. Med. Bull. 1981; 37: 89
        • Chandra R.K.
        Immunodeficiency in undernutrition and overnutrition.
        Nutr. Rev. 1981; 39: 225
      1. Chandra, R. K.: Marginal malnutrition and immunocompetence. Proceed. Fifteenth International Congress of Nutrition. New York, Alan Liss, in press.

      2. Chandra, R. K.: Immunocompetence and the assessment of nutritional status. Diagn. Med., in press.

      3. Chandra, R. K. (ed): Immunodeficiency Disorders. Edinburgh, Churchill-Livingstone, in press.

        • Chandra R.K.
        • Newberne P.M.
        Nutrition, Immunity and Infection: Mechanisms of Interactions.
        Plenum, New York1977
        • Chandra R.K.
        • Scrimshaw N.S.
        Immunocompetence in nutritional assessment.
        Am. J. Clin. Nutr. 1980; 33: 2694
        • Dionigi R.
        • Bonera A.
        • Dominioni L.
        Nutrition and infection.
        J. Parent. Ent. Nutr. 1979; 3: 62-68
        • Dionigi P.
        • Dionigi R.
        • Nazari S.
        • et al.
        Nutritional and immunologic evaluations in cancer patients. Relationship to surgical infections.
        J. Parent. Ent. Nutr. 1979; 3: 349
        • Dreizen S.
        Nutrition and the immune response.
        Int. J. Vit. Nutr. Res. 1978; 40: 220-228
        • Ferguson A.S.
        • Lawlor Jr., G.J.
        • Neumann C.G.
        • et al.
        Decreased rosette-forming lymphocytes in malnutrition and intrauterine growth retardation.
        J. Pediatr. 1974; 85: 717
        • Gross R.L.
        • Newberne P.M.
        Role of nutrition in immunologic function.
        Physiol. Rev. 1980; 60: 188
        • Kielman A.A.
        • Uberoi I.S.
        • Chandra R.K.
        • et al.
        The effect of nutritional status on immune capacity and immune responses in preschool children in a rural community in India.
        Bull. WHO. 1976; 54: 477
        • McMurray D.N.
        • Rey H.
        • Casazza L.J.
        • et al.
        Effect of moderate malnutrition on concentrations of immunoglobulins and enzymes in tears and saliva of young Colombian children.
        Am. J. Clin. Nutr. 1977; 30: 1944-1948
        • McMurray D.N.
        • Loomis S.A.
        • Casazza L.J.
        • et al.
        Development of impaired cell-mediated immunity in mild and moderate malnutrition.
        Am. J. Clin. Nutr. 1981; 34: 63
        • Meakins J.L.
        • Pietsch J.B.
        • Bubenick O.
        Delayed hypersensitivity: Indicator of acquired failure of host defenses in sepsis and trauma.
        Ann. Surg. 1977; 186: 241
        • Neumann C.G.
        • Lawlor C.G.
        • Steihm E.R.
        • et al.
        Immunological responses in malnourished children.
        Am. J. Clin. Nutr. 1975; 28: 89
      4. Scrimshaw, N. S., Taylor, C. E., and Gordon, J. E.: Interactions of nutrition and infection. WHO Monograph Series 57, Geneva, 1968.

        • Seltzer M.H.
        • Bastidas J.A.
        • Cooper D.M.
        • et al.
        Instant nutritional assessment.
        J. Parent. Ent. Nutr. 1979; 3: 157-159
        • Selvaraj R.J.
        • Bhat K.S.
        Metabolic and bactericidal activities of leukocytes in protein-calorie malnutrition.
        Am. J. Clin. Nutr. 1972; 25: 166
        • Seth V.
        • Chandra R.K.
        Opsonic activity, phagocytosis and intra-cellular bactericidal capacity of polymorphs in under-nutrition.
        Arch. Dis. Child. 1972; 47: 282
        • Sirisinha S.
        • Suskind R.
        • Edelman R.
        • et al.
        Complement and C3 proactivator levels in children with protein-calorie malnutrition and effect of dietary treatment.
        Lancet. 1973; 1: 1016
        • Watson R.R.
        • McMurray D.N.
        The effects of malnutrition on secretory and cellular immune processes.
        Crit. Rev. Food Sei. Nutr. 1979; 12: 113
      5. W.H.O. Scientific Group: Immunodeficiency. Tech. Rept., Ser. 630, 1978.

        • Ziegler H.D.
        • Ziegler P.B.
        Depression of tuberculin reaction in mild and moderate protein-calorie malnourished children following BCG vaccination.
        Johns Hopkins Med. J. 1975; 137: 59-64