Research Article| Volume 2, ISSUE 1, P211-219, March 1982

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The Mechanisms of Destruction of Antibody-altered Cells

  • Wendell F. Rosse
    Corresponding author: Box 3934M, Duke University Medical Center, Durham, North Carolina 27710
    Florence McAllister Professor of Medicine and Professor of Immunology, and Chief, Division of Hematology-Oncology, Duke University Medical Center, Durham, North Carolina
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      The mechanisms by which erythrocytes are destroyed are exceedingly complex and involve both the humoral and cellular immune systems. In most cases, the signal for cell destruction is mediated by antibody. Although complement is a useful adjuvant to immune destruction, it now appears that, by itself, it is a relatively poor effector of immune destruction.
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