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To answer the question of whether reference values are useful in clinical decision-making,
this article addresses the following major controversies: (1) Are reference subjects
representative of the group from which they are selected? (2) To what extent should
the process of collecting reference values be standardized and controlled? (3) Can
a single distribution of reference values be used in an meaningful way in the process
of clinical decision-making.
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References
- Recommendations concerning the collection of reference values in clinical chemistry and activity report.Scand. J. Clin. Lab. Invest. 1975; 35: 1-44
- Establishment and use of normal values.Scand. J. Clin. Lab. Invest. 1969; 24: 62
- Statistical aspects of reference values in clinical pathology.in: Stefani M. Benson E.S. Progress in Clinical Pathology. Vol. 8. Grune and Stratton, New York1981: 45
- Preparing reference individuals for blood specimen collection.in: Grasbeck R. Alstrom T. Reference Values in Laboratory Medicine. John Wiley and Sons, New York1981: 105
- Provisional recommendation on the theory of reference values.Clin. Chim. Acta. 1978; 87: 459F-465F
- Statistical treatment of collected reference values and determination of reference limits.in: Grasbeck R. Alstrom T. Reference Values in Laboratory Medicine. John Wiley and Sons, New York1983: 193
- Clinical Decision Levels for Lab Tests.Medical Economics, Oradell, New Jersey1983
Statland, B. E.: Turning lab values into action. Diagn. Med., September 1980, p. 56.
- Effects of non-analytical factors on the intraindividual variation of analytes in the blood of healthy subjects: Consideration of preparation of the subject and time of venipuncture.CRC Crit. Rev. Clin. Lab. Sei. 1977; 8: 105
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© 1984 Elsevier Inc. Published by Elsevier Inc. All rights reserved.
