Research Article| Volume 4, ISSUE 4, P729-744, December 1984

Assessment of Hormonal Disorders of Water Metabolism

  • Myron Miller
    Corresponding author: VA Medical Center, 800 Irving Avenue, Syracuse, New York 13210
    Professor of Medicine, SUNY Upstate Medical Center; Medical Service, VA Medical Center, Syracuse, New York
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      The pathophysiology of clinical disorders of water regulation can be elucidated both by measurement of the antidiuretic hormone (ADH) in blood and urine through RIA and by tests that assess the release of ADH from the neurohypophysial system through its action on the kidney. These procedures are capable of making an accurate diagnosis of water-losing and water-retaining disorders. The functional tests (water deprivation, hypertonic saline infusion, comparison of simultaneous urine and serum osmolality and water loading) are simple, readily available, relatively inexpensive, and can obviate the need for direct measurement of AVP by RIA in evaluating most clinical disorders of water regulation.
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        • Alhenc-Gelas F.
        • Fressinaud P.
        • Corvol P.
        • et al.
        Etude de l’excretion urinaire del’hormone antidiurétique chez 1’homme normal.
        J. D’Urologie et Néphrologie. 1974; 80: 955-960
        • Aubry R.H.
        • Nankin H.R.
        • Moses A.M.
        • et al.
        Measurement of osmotic threshold for vasopressin release in human subjects and its modification by cortisol.
        J. Clin. Endocrinol. Metab. 1965; 25: 1481-1492
        • Bartter F.C.
        • Schwartz W.B.
        The syndrome of inappropriate secretion of antidiuretic hormone.
        Am. J. Med. 1967; 42: 790-806
        • Beardwell C.G.
        • Geelen G.
        • Palmer H.M.
        • et al.
        Radioimmunoassay of plasma vasopressin in physiological and pathological states in man.
        J. Endocrinol. 1975; 67: 189-202
        • Camps J.
        • Martinez-Vea A.
        • Perez-Ayuso R.M.
        • et al.
        Radioimmunoassay for arginine-vasopressin in cold ethanol extracts of plasma.
        Clin. Chem. 1983; 29: 882-884
        • Comis R.L.
        • Miller M.
        • Ginsberg S.J.
        Abnormalities in water homeostasis in small cell anaplastic lung cancer.
        Cancer. 1980; 45: 2414-2421
        • Czernichow P.
        • Merkelbach U.
        • Vallotton M.B.
        Radioimmunoassay of [8-arginine]-vasopressin. I. Methodology.
        Acta Endocrinol. (Kbh). 1975; 80: 444-452
        • DeFronzo R.A.
        • Goldberg M.
        • Agus Z.S.
        Normal diluting capacity in hyponatremic patients. Reset osmostat or a variant of the syndrome of inappropriate antidiuretic hormone secretion.
        Ann. Intern. Med. 1976; 84: 538-542
        • DeRubertis F.R.
        • Michelis M.F.
        • Beck N.
        • et al.
        Essential hypernatremia due to ineffective osmotic and intact volume regulation of vasopressin secretion.
        J. Clin. Invest. 1971; 50: 97-111
        • Fressinaud P.
        • Corvol P.
        • Menard J.
        Radioimmunoassay of urinary antidiuretic hormone in man: Stimulation-suppression tests.
        Kidney Int. 1974; 6: 184-190
        • Husain M.K.
        • Fernando N.
        • Shapiro M.
        • et al.
        Radioimmunoassay of argininevasopressin in human plasma.
        J. Clin. Endocrinol. Metab. 1973; 37: 616-625
        • Karonen S.L.
        • Morsky P.
        • Siren M.
        • et al.
        An enzymatic solid-phase method for trace iodination of proteins and peptides with 125iodine.
        Analyt. Biochem. 1975; 67: 1-10
        • Larochelle Jr., F.T.
        • North W.G.
        • Stern P.
        A new extraction of argininevasopressin from blood: The use of octadecasilyl-silica.
        Pflügers Arch. 1980; 367: 79-81
        • Merkelbach U.
        • Czernichow P.
        • Gaillard R.C.
        • Vallotton M.B.
        Radioimmunoassay of [8-arginine]-vasopresin. II. Application to determination of antidiuretic hormone in urine.
        Acta Endocrinol. (Kbh). 1975; 60: 453-464
        • Miller M.
        • Dalakos T.
        • Moses A.M.
        • et al.
        Recognition of partial defects in antidiuretic hormone secretion.
        Ann. Intern. Med. 1970; 73: 721-729
        • Miller M.
        • Moses A.M.
        Radioimmunoassay of vasopressin with a comparison of immunological and biological activity in the rat posterior pituitary.
        Endocrinology. 1969; 84: 556-562
        • Miller M.
        • Moses A.M.
        Radioimmunoassay of urinary antidiuretic hormone with application to study of the Brattleboro rat.
        Endocrinology. 1971; 66: 1389-1396
        • Miller M.
        • Moses A.M.
        Radioimmunoassay of urinary antidiuretic hormone in man: Response to water load and dehydration in normal subjects.
        J. Clin. Endocrinol. Metab. 1972; 34: 537-545
        • Miller M.
        • Moses A.M.
        Urinary antidiuretic hormone in polyuric disorders and in inappropriate ADH syndrome.
        Ann. Intern. Med. 1972; 77: 715-721
        • Miller M.
        • Moses A.M.
        Drug-induced states of impaired water excretion.
        Kidney Int. 1976; 10: 96-103
        • Miller M.
        • Moses A.M.
        Clinical states due to alteration of ADH release and action.
        in: Moses Share Neurohypophysis: Proceedings of the International Conference on the Neurohypophysis. S. Karger AG, Basel1977: 153-166
        • Morton J.J.
        • Padfield P.L.
        • Forsling M.L.
        A radioimmunoassay for plasma arginine-vasopressin in men and dogs: Application to physiological and pathological states.
        J. Endocrinol. 1975; 65: 411-424
        • Moses A.M.
        • Miller M.
        Drug-induced dilutional hyponatremia.
        N. Engl. J. Med. 1974; 291: 1234-1239
        • Moses A.M.
        • Miller M.
        • Streeten D.H.P.
        Pathophysiologic and pharmacologic alterations in the release and action of ADH.
        Metabolism. 1976; 25: 697-721
        • Moses A.M.
        • Streeten D.H.P.
        Differentiation of polyuric states by measurement of responses to changes in plasma osmolality induced by hypertonic saline infusions.
        Am. J. Med. 1967; 42: 368-377
        • Oyama S.N.
        • Kagan A.
        • Glick S.M.
        Radioimmunoassay of vasopressin: Application to unextracted human urine.
        J. Clin. Endocrinol. Metab. 1971; 33: 739-744
        • Pullan P.T.
        • Clappison B.H.
        • Johnston C.I.
        Plasma vasopressin and human neurophysins in physiological and pathological states associated with changes in vasopressin secretion.
        J. Clin. Endocrinol. Metab. 1979; 49: 580-587
        • Robertson G.L.
        • Athar S.
        The interaction of blood osmolality and blood volume in regulating plasma vasopressin in man.
        J. Clin. Endocrinol. Metab. 1976; 42: 613-620
        • Robertson G.L.
        • Mahr E.A.
        • Athar S.
        • Sinha T.
        Development and clinical application of a new method for the radioimmunoassay of arginine vasopressin in human plasma.
        J. Clin. Invest. 1973; 52: 2340-2352
        • Robertson G.L.
        • Shelton R.L.
        • Athar S.
        The osmoregulation of vasopressin.
        Kidney Int. 1976; 10: 25-37
        • Skowsky W.R.
        • Rosenbloom A.A.
        • Fisher D.A.
        Radioimmunoassay measurement of arginine vasopressin serum: Development and application.
        J. Clin. Endocrinol. Metab. 1974; 36: 278-287
        • Streeten D.H.P.
        • Moses A.M.
        • Miller M.
        Disorders of the neurohypophysis.
        in: Petersdorf Harrison’s Principles of Internal Medicine. 10th ed. McGraw-Hill, New York1983: 604-614
        • Tausch A.
        • Stegner H.
        • Leake R.D.
        • et al.
        Radioimmunoassay of arginine vasopressin in urine: Development and application.
        J. Clin. Endocrinol. Metab. 1983; 57: 777-781
        • Thomas T.H.
        • Lee M.R.
        The specificity of antisera for the radioimmunoassay of arginine-vasopressin in human plasma and urine during water loading and dehydration.
        Clin. Sei. Molec. Med. 1976; 51: 525-536
        • Thorell J.I.
        • Johansson B.G.
        Enzymatic iodination of polypeptides with 125I to high specific activity.
        Biochem. Biophys. Acta. 1971; 251: 363-369
        • Uhlich E.
        • Weber P.
        • Groschel-Steward U.
        • et al.
        Radioimmunoassay of arginine vasopressin in human plasma.
        Hormone Metab. Res. 1975; 7: 501-507
        • Zerbe R.L.
        • Robertson G.L.
        A comparison of plasma vasopressin measurements with a standard indirect test in the differential diagnosis of polyuria.
        N. Engl. J. Med. 1981; 305: 1539-1546