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Special Article| Volume 5, ISSUE 1, P109-119, March 1985

Emerging Patterns of Microbial Resistance

  • John A. Washington II
    Correspondence
    Corresponding author: Section of Clinical Microbiology, Mayo Clinic, 200 First Street S.W., Rochester, Minnesota 55905
    Affiliations
    Head, Section of Clinical Microbiology, Mayo Clinic and Foundation; Professor of Microbiology and Laboratory Medicine, Mayo Medical School, Rochester, Minnesota
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DOI:https://doi.org/10.1016/S0272-2712(18)30885-0
Emerging Patterns of Microbial Resistance
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      Microbial resistance arises by mutation or by inheritance. The latter is plasmid-mediated and transferable and may erode multidrug resistance to ß-lactams, aminoglycosides, tetracyclines, macrolides, lincosamides, sulfonamides, and trimethoprim. Resistance genes may transfer from one plasmid to another or from a plasmid to the chromosome or to a bacteriophage, thereby allowing rapid dissemination of resistance among bacteria. Mutational or chromosomal resistance is not readily transferable between different bacterial species or genera but is nonetheless medically important for resistance to isoniazid, methicillin, nalidixic acid, rifampin, and expanded spectrum cephalosporins.
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      References

        • Archer G.L.
        • Johnston J.L.
        Self-transmissible plasmids in staphylococci that encode resistance to aminoglycosides.
        Antimicrob. Agents Chemother. 1983; 24: 70-77
        • Blumenthal R.M.
        • Raeder R.
        • Takemoto C.D.
        • et al.
        Occurrence and expression of imipemide (IV-formimidoyl-thienamycin) resistance in clinical isolates of coagulase-negative staphylococci.
        Antimicrob. Agents Chemother. 1983; 24: 61-69
        • Bulger R.R.
        • Washington II, J.A.
        In vitro activity of cephalosporins against Hae mophilus species.
        in: Current Chemotherapy and Infectious Disease. American Society for Microbiology, Washington, D.C.1980: 1026-1027
        • Centers for Disease Control
        Spectinomycin-resistant penicillinase-producing Neisseria gonorrhoeae.
        M.M.W.R. 1983; 32: 51-52
        • Centers for Disease Control
        Penicillin-resistant gonorrhea—North Carolina.
        M.M.W.R. 1983; 32: 273-275
        • Davies J.
        Mechanisms of antibiotic resistance.
        in: Current Concepts. The Upjohn Company, Kalamazoo, Michigan1980: 1-44
        • Davies J.E.
        Resistance to aminoglycosides: Mechanisms and frequency.
        Rev. Infect. Dis. 1983; 5: S261-S266
        • Edson R.S.
        • Rosenblatt J.E.
        • Lee D.T.
        • et al.
        Recent experience with antimicrobial susceptibility of anaerobic bacteria: Increasing resistance to penicillin.
        Mayo Clin. Proc. 1982; 57: 737-741
        • Finland M.
        Emergence of antibiotic resistance in hospitals, 1935–1975.
        Rev. Infect. Dis. 1979; 1: 4-21
        • Gilbert D.N.
        • Sanford J.P.
        A clinical perspective of antibiotic therapy: Aminoglycosides vs.
        broad-spectrum β-lactams. Rev. Infect. Dis. 1983; 5: S211-S398
        • Haley R.W.
        • Hightower A.W.
        • Khabbaz R.M.
        • et al.
        The emergence of methicillin-resistant Staphylococcus aureus infections in United States hospitals: Possible role of the house staff-patient transfer circuit.
        Ann. Intern. Med. 1982; 97: 297-308
        • Heimdahl A.
        • von Konow L.
        • Nord C.E.
        Beta-lactamase-producing Bacteroides species in the oral cavity in relation to penicillin therapy.
        J. Antimicrob. Chemother. 1981; 3: 225-229
        • Jackson G.G.
        Aminoglycoside antibiotics: Resistance and toxicity—an introduction.
        Rev. Infect. Dis. 1983; 5: S260
        • Jacobs M.R.
        • Koornhof H.J.
        • Robins-Browne R.M.
        • et al.
        Emergence of multiply resistant pneumococci.
        N. Engl. J. Med. 1978; 299: 735-740
        • Karchmer A.W.
        • Archer G.L.
        • Dismukes W.E.
        Staphylococcus epidermidis causing prosthetic valve endocarditis: Microbiologic and clinical observations.
        Ann. Intern. Med. 1983; 93: 447-455
        • Levy S.B.
        Microbial resistance to antibiotics: An evolving and persistent problem.
        Lancet. 1982; 2: 83-88
        • Markowitz S.M.
        Isolation of an ampicillin-resistant, non-β-lactamase-producing strain of Haemophilus influenzae.
        Antimicrob. Agents Chemother. 1980; 17: 80-83
        • Marsh P.K.
        • Malamy M.H.
        • Shimell M.J.
        • et al.
        Sequence homology of clindamycin resistance determinants in clinical isolates of Bacteroides spp.
        Antimicrob. Agents Chemother. 1983; 23: 726-730
        • Mederski-Samoraj B.D.
        • Murray B.E.
        High-level resistance to gentamicin in clinical isolates of enterococci.
        J. Infect. Dis. 1983; 147: 751-757
        • Moellering Jr., R.C.
        Antibiotic synergism—lessons from the enterococcus.
        Trans. Am. Clin. Climatol. Assoc. 1983; 94: 55-62

      21. Murray, B.E., and Mederski-Samoraj, B.: Transferable β-lactamase in a clinical isolate of Streptococcus faecalis. Abstracts of the 22nd Interscience Conference on Antimicrobial Agents and Chemotherapy, 1982, Abstract 714.

        • Murray B.E.
        • Tsao J.
        • Panida J.
        Enterococci from Bangkok, Thailand, with high-level resistance to currently available aminoglycosides.
        Antimicrob. Agents Chemother. 1983; 23: 799-802
        • Murray P.R.
        • Granich G.G.
        • Krogstad D.J.
        • et al.
        In vivo selection of resistance to multiple cephalosporins by Enterobacter cloacae.
        J. Infect. Dis. 1983; 147: 590
        • Nord C.E.
        • Olsson-Liljequist B.
        Resistance to β-lactam antibiotics in Bacteroides species.
        J. Antimicrob. Chemother. 1981; 8: 33-42
        • Ogawara H.
        Antibiotic resistance in pathogenic and producing bacteria, with special reference to β-lactam antibiotics.
        Microbiol. Rev. 1981; 45: 591-619
        • Olson B.
        • Weinstein R.A.
        • Nathan C.
        • et al.
        Broad-spectrum β-lactam resistance in Enterobacter: Emergence during treatment and mechanisms of resistance.
        J. Antimicrob. Chemother. 1983; 11: 299-310
        • Preheim L.C.
        • Penn R.G.
        • Sanders C.C.
        • et al.
        Emergence of resistance to β-lactam and aminoglycoside antibiotics during moxalactam therapy of Pseudomonas aeruginosa infections.
        Antimicrob. Agents Chemother. 1982; 22: 1037-1041
        • Rodriguez J.
        • Fuxench-Chiesa Z.
        • Ramirez-Ronda C.H.
        • et al.
        In vitro susceptibility of 50 non-β-lactamase—producing Neisseria gonorrhoeae strains to 12 antimicrobial agents.
        Antimicrob. Agents Chemother. 1983; 23: 242-244
        • Sanders C.C.
        Novel resistance selected by the new expanded-spectrum cephalosporins: A concern.
        J. Infect. Dis. 1983; 147: 585-589
        • Spratt B.G.
        Penicillin-binding proteins and the future of β-lactam antibiotics.
        J. Gen. Microbiol. 1983; 129: 1247-1260
        • Sykes R.B.
        • Bush K.
        Interaction of new cephalosporins with β-lactamases and β-lactamase-producing gram-negative bacilli.
        Rev. Infect. Dis. 1983; 5: S356-S366
        • Tally F.P.
        • Cuchural G.J.
        • Jacobus N.V.
        • et al.
        Susceptibility of the Bacteroides fragilis group in the United States in 1981.
        Antimicrob. Agents Chemother. 1983; 23: 536-540
        • Thornsberry C.
        • McDougal L.K.
        Ampicillin-resistant Haemophilus influenzae. 1. Incidence, mechanism, and detection.
        Postgrad. Med. 1982; 71: 133-145
        • Timewell R.
        • Taylor E.
        • Phillips I.
        The β-lactamases of Bacteroides species.
        J. Antimicrob. Chemother. 1981; 7: 137-146
        • Wade J.C.
        • Schimpff S.C.
        • Newman K.A.
        • et al.
        Staphylococcus epidermidis: An in creasing cause of infection in patients with granulocytopenia.
        Ann. Intern. Med. 1982; 97: 503-508
        • Washington II, J.A.
        Bacteriology, clinical spectrum of disease, and therapeutic aspects in coryneform bacterial infection.
        in: Remington J.S. Swartz M.N. Current Clinical Topics in Infectious Diseases. McGraw-Hill, New York1981: 68-88

      Article info

      Footnotes

      This article first appeared in Orthopedic Clinics of North America, Vol. 15, No. 3, July 1984, as part of a symposium on musculoskeletal sepsis.

      Identification

      DOI: https://doi.org/10.1016/S0272-2712(18)30885-0

      Copyright

      © 1985 Elsevier Inc. Published by Elsevier Inc. All rights reserved.

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