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Research Article| Volume 5, ISSUE 2, P317-329, June 1985

Current Assessment of Microhematuria and Leukocyturia

  • Uma A. Shenoy
    Correspondence
    Division of Cytology, Department of Pathology, University of Utah School of Medicine, Salt Lake City, Utah 84117
    Affiliations
    Fellow in Cytopathology, Division of Cytology, Department of Pathology, University of Utah School of Medicine, Salt Lake City, Utah
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DOI:https://doi.org/10.1016/S0272-2712(18)30872-2
Current Assessment of Microhematuria and Leukocyturia
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      Technical advances in laboratory testing such as sensitive chemical tests and standardized commercial slides have significantly altered our entire approach to urinalysis. In addition, the recognition of the association of microhematuria with urologic neoplasms and the morphologically altered red blood cells with renal parenchymal bleeding is beginning to expand our knowledge of the pathogenesis of microhematuria. Future trends may include a broader range of chemical tests as well as a better understanding of disease processes associated with microhematuria.
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      References

        • Adams E.C.
        • Fedder M.C.
        • Free H.M.
        • et al.
        Hemolysis in hematuria.
        J. Urol. 1962; 88: 427
        • Addis T.
        The effect of some physiological variables on the number of casts, RBCs, WBCs and epithelial cells in the urine of normal individuals.
        J. Clin. Invest. 1926; 2: 417-421
        • Addis T.
        The number of formed elements in the urinary sediment of normal individuals.
        J. Clin. Invest. 1928; 2: 409-415
        • Addis T.
        Glomerular Nephritis: Diagnosis and Treatment.
        Macmillan, New York1948: 10-12
        • Avent J.
        • Schumann G.B.
        • Vars L.
        Comparison of the chemstrip leukocyte test with a standardised Papanicolaou-stained urine sediment evaluation.
        Lab. Med. 1983; 14: 163-166
        • Birch D.F.
        • Fairley K.F.
        Hematuria: Glomerular or non-glomerular?.
        Lancet. 1979; 1: 845-846
        • Birch D.F.
        • Fairley K.F.
        Red cells in the urine.
        Lancet. 1980; 1: 424
        • Carson C.C.
        • Segura J.W.
        • Greene L.F.
        Clinical importance of microhematuria.
        J.A.M.A. 1979; 241: 149-150
        • Chang B.S.
        Red cell morphology as a diagnostic aid in hematuria.
        J.A.M.A. 1984; 252: 1747-1749

      10. Chemstrip 9 Instruction Sheets, Indianapolis, Biodynamics, 1984.

        • Cook M.H.
        • Free A.H.
        • Giordano A.S.
        Studies with a simple test for the detection of occult blood in urine.
        J. Urol. 1956; 75: 743-752

      12. Detection of leukocytes in urine by means of a test strip: A cooperative study at eleven centers. Dsch. Med. Wochenschr., 104:1236-1240, 1979.

        • Fairley K.F.
        • Barraclough M.
        Leukocyte excretion rate as a screening test for bacteriuria.
        Lancet. 1967; 1: 420-421
        • Fairley K.F.
        • Birch D.F.
        Hematuria: A simple method for identifying glomerular bleeding.
        Kidney Int. 1982; 21: 105-108
        • Fassett R.G.
        • Horgan B.A.
        • Mathew T.H.
        Detection of glomerular bleeding by phase-contrast microscopy.
        Lancet. 1982; 1: 1432-1434
        • Firfer R.
        Clinical importance of microhematuria.
        J.A.M.A. 1979; 241 (editorial): 165-166
        • Free H.M.
        • Free A.H.
        • Giordano A.S.
        Studies with a simple test for the detection of occult blood in urine.
        J. Urol. 1956; 75: 743-752
        • Freidman E.A.
        • Morris R.C.
        Renal failure, myoglobinuria and hemoglobinuria.
        J.A.M.A. 1981; 246: 685
        • Freni S.S.
        • Freni-Titulaer L.W.J.
        Microhematuria found by mass screening of apparently healthy males.
        Acta Cytol. 1977; 21: 421-423
        • Freni S.S.
        • Heederik G.J.
        • Hol C.
        Centrifugation techniques and reagent-strips in the assessment of microhematuria.
        J. Clin. Pathol. 1977; 30: 336-340
        • Gadeholt H.
        Quantitative estimation of urinary sediment with special regard to sources of error.
        Br. Med. J. 1964; 1: 1547-1549
        • Gillenwater J.Y.
        Detection of urinary leukocytes by chemstrip-L.
        J. Urol. 1981; 125: 383-384
        • Goldring W.
        Studies of the kidney in acute infection.
        J. Clin. Invest. 1931; 10: 355
        • Greene L.F.
        • O’Shaughnessy Jr., E.J.
        • Hendricks E.D.
        Study of five hundred patients with asymptomatic microhematuria.
        J.A.M.A. 1956; 161: 610-613

      25. Hemastix Technical Insert (revised), 1980. Ames Co., Elkhart, Indiana.

      26. Hemastix Technical Insert, 1962. Ames Co., Elkhart, Indiana.

      27. Hematest Instruction Sheet, 1946. Ames Co., Elkhart, Indiana.

        • Henry J.B.
        Clinical Diagnosis and Management by Laboratory Methods.
        Edition 16. W. B. Saunders Co., Philadelphia1979
        • Houghton B.J.
        • Pears M.A.
        Cell excretion in normal urine.
        Br. Med. J. 1957; 1: 622-625
        • Jaenike J.R.
        The renal lesion associated with hemoglobinemia.
        J. Exp. Med. 1966; 123: 523-535
        • Jaenike J.R.
        • Schneeberger E.E.
        The renal lesion associated with hemoglobinemia.
        J. Exp. Med. 1966; 123: 537-545
        • Kagen L.J.
        Immunofluorescent demonstration of myoglobin in the kidney.
        Am. J. Med. 1970; 48: 649-653
        • Kierkegaard H.
        • Feldt-Rasmussen U.
        • Horder M.
        • et al.
        Falsely negative urinary leukocyte counts due to delayed examination.
        Scand. J. Clin. Lab. Invest. 1980; 40: 259-261
        • Kupor L.R.
        • Mullins J.D.
        • McPhaul J.J.
        Immunopathologic findings in idiopathic renal hematuria.
        Arch. Intern. Med. 1975; 135: 1204-1211
        • Kusumi R.K.
        • Grover P.J.
        • Kunin C.M.
        Rapid detection of pyuria by leukocyte esterase activity.
        J.A.M.A. 1981; 245: 1653-1655
        • Lee L.W.
        • Davis Jr., E.
        Gross urinary hemorrhage: A symptom, not a disease.
        J.A.M.A. 1953; 153: 782-784
        • Leonards J.R.
        Simple test for hematuria compared with established tests.
        J.A.M.A. 1962; 179: 807-808
        • Lindquist B.
        • Wahlin A.
        Differential count of urinary leukocytes and renal epithelial cells by phase contrast microscopy.
        Acta Med. Scand. 1975; 198: 505
        • Longfield G.M.
        • Holland D.E.
        • Lake A.J.
        • et al.
        Hematuria: Comparison of chemical and microscopic examination.
        J. Mich. St. Med. Soc. 1960; 59: 785-786
        • Loo S.Y.T.
        • Scotolini A.G.
        • Luangphinith S.
        • et al.
        Urine screening strategy employing dipstick analysis and selective culture: An evaluation.
        Am. J. Clin. Pathol. 1984; 18: 634-642
        • Michael J.
        • Jones N.F.
        • Davies D.R.
        • et al.
        Recurrent hematuria, role of renal biopsy and investigative morbidity.
        Br. Med. J. 1976; 1: 686-688
        • Musher D.M.
        • Thorsteinsson S.B.
        • Airola V.M.
        Quantitative urinalysis diagnosing urinary tract infection in men.
        J.A.M.A. 1976; 236: 2069-2072
        • Nanji A.A.
        • Adam W.
        • Campbell D.J.
        Routine microscopic examination of the urine sediment. Should we continue?.
        Arch. Pathol. Lab. Med. 1984; 108: 399-400
        • Overton K.
        • Jones P.
        • Jones R.N.
        A new reagent-strip for urinalysis.
        Pathologist. 1984; 38: 356-361
        • Pai S.H.
        Microscopic examination of urine sediment.
        J.A.M.A. 1979; 241: 1574
        • Prescott L.F.
        Urinary white cell excretion patterns.
        Lancet. 1965; 2: 238
        • Sanders C.
        Clinical urine examination and the incidence of microscopic hematuria in apparently normal males.
        Practitioner. 1963; 191: 192-197
        • Schumann G.B.
        • Schumann J.L.
        • Schweitzer S.
        The urine sediment examination: A coordinated approach.
        Lab. Management. 1983; 21: 45-48
        • Schumann G.B.
        • Weiss M.A.
        Atlas of Renal and Urinary Tract Cytology and Its Histopathologic Bases.
        J. B. Lippincott Co., Philadelphia1981

      50. Shenoy, U. A., Schumann, G. B., and De Bellis, C. C.: Incidence of MH in urothelial neoplasia (unpublished data).

        • Smith B.C.
        • Peake M.J.
        • Fraser C.G.
        Urinalysis by use of the multitest reagent strips: Two dipsticks compared.
        Clin. Chem. 1977; 23: 2337-2340
        • Spear G.S.
        • Roskes S.D.
        • Slusser R.J.
        • et al.
        Idiopathic hematuria of childhood.
        Hum. Pathol. 1973; 4: 349-390
        • Sternheimer R.
        A supravital cytodiagostic stain for urinary sediments.
        J.A.M.A. 1975; 231: 826-832
        • Triger D.R.
        • Smith J.W.C.
        Survival of urinary leukocytes.
        J. Clin. Pathol. 1966; 19: 443
        • Valenstein P.N.
        • Koepke J.A.
        Unnecessary microscopy in routine urinalysis.
        Am. J. Clin. Pathol. 1984; 82: 444-448
        • Van de Putte L.B.A.
        • de La Riviere G.B.
        • Van Breda Vriesman P.J.C.
        Recurrent or persistent hematuria.
        N. Engl. J. Med. 1974; 290: 1165-1170
        • Wenk R.E.
        • Dutta D.
        • Rudert J.
        • et al.
        Sediment microscopy, nitrituria, and leukocyte esterasuria as predictors of significant bacteriuria.
        J. Clin. Lab. Auto. 1982; 2: 117-121
        • Williams G.A.
        • Kent S.P.
        Specific identification of hemoglobin and myoglobin in renal tubular casts by the fluorescent antibody technic on fixed embedded tissues.
        Am. J. Clin. Pathol. 1981; 75: 726-730
        • Wise K.A.
        • Sagert L.A.
        • Grammens G.L.
        Urine leukocyte esterase and nitrite tests as an aid to predict urine culture results.
        Lab. Med. 1984; 15: 186-187
        • Wright W.T.
        Cell counts in urine.
        Arch. Intern. Med. 1959; 103: 76-78

      Article info

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      DOI: https://doi.org/10.1016/S0272-2712(18)30872-2

      Copyright

      © 1985 Elsevier Inc. Published by Elsevier Inc. All rights reserved.

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