Research Article| Volume 5, ISSUE 2, P303-315, June 1985

Assessment of Tumor Markers in Cerebrospinal Fluid

  • Kurt A. Jaeckle
    Department of Neurology, University of Utah Medical Center, Salt Lake City, Utah 84132
    Assistant Professor of Neurology, University of Utah Health Sciences Center, Salt Lake City, Utah
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      In clinical practice, the examination of cerebrospinal fluid from patients with primary or metastatic brain tumors is commonly limited to cytomorphologic and routine chemistry analysis. The relative lack of sensitivity and specificity of these tests has led to a search for markers that can detect nervous system involvement by neoplasms at an earlier stage and even predict the site of origin of the neoplasms. This article summarizes recent investigators of biochemical tumor markers and cytoplasmic and cell surface markers in cerebrospinal fluid from patients with nervous system tumors.
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