Advertisement
Research Article| Volume 5, ISSUE 2, P233-264, June 1985

Use of Immunologic Tumor Makers in Body Fluid Analysis

DOI:https://doi.org/10.1016/S0272-2712(18)30868-0
Use of Immunologic Tumor Makers in Body Fluid Analysis
Previous ArticleElectron Microscopy of Body Fluids
Next ArticlePrognostic Value of Cytologic Peritoneal Wahings
      This paper is only available as a PDF. To read, Please Download here.
      Sensitive and specific tumor markers will increase the accuracy of present cytologic techniques and will teach us more about the biology and pathogenesis of tumors. Immunoenzyme studies may also be useful in quality control and may accelerate the development of automated screening techniques for cytology.
      To read this article in full you will need to make a payment

      Purchase one-time access:

      Academic & Personal: 24 hour online accessCorporate R&D Professionals: 24 hour online access
      One-time access price info
      • For academic or personal research use, select 'Academic and Personal'
      • For corporate R&D use, select 'Corporate R&D Professionals'

      Subscribers receive full online access to your subscription and archive of back issues up to and including 2002.

      Content published before 2002 is available via pay-per-view purchase only.

      Subscribe:

      Subscribe to Clinics in Laboratory Medicine
      Already a print subscriber? Claim online access
      Already an online subscriber? Sign in
      Register: Create an account
      Institutional Access: Sign in to ScienceDirect

      References

        • Andres T.L.
        • Kain M.E.
        Immunologic markers in the differential diagnosis of small round cell tumors from lymphocytic lymphoma and leukemia.
        Am. J. Clin. Pathol. 1983; 79: 546-550
        • Asseo P.P.
        • Tracopoulos G.D.
        Orosomucoid, α2-macroglobulin and immunoglobulins in serum and pleural effusions.
        Am. J. Clin. Pathol. 1981; 76: 437-441
        • Battifora H.
        Recent progress in the immunohistochemistry of solid tumors.
        Semin. Diagn. Pathol. 1984; 1: 251-271
        • Battifora H.
        • Trowbridge I.S.
        A monoclonal antibody useful for the differential diagnosis between malignant lymphoma and non-hematopoietic neoplasms.
        Cancer. 1983; 51: 816-821
        • Bollum F.J.
        Terminal deoxynucleotidyl transferase as a hematopoietic cell marker.
        Blood. 1979; 54: 1203-1215
        • Borowitz M.J.
        • Stevanovic G.
        • Gotfired M.
        Differential diagnosis of undifferentiated malignant tumors with monoclonal antibody T29/33.
        Hum. Pathol. 1984; 15: 928-934
        • Bradstock K.F.
        • Papageorgiou E.S.
        • Janossy G.
        Diagnosis of meningeal involvement in patients with acute lymphoblastic leukemia: Immunofluorescence for terminal transferase.
        Cancer. 1981; 47: 2478-2481
        • Braziel R.M.
        • Keneklis T.
        • Donlon J.A.
        • et al.
        Terminal deoxynucleotidyl transferase in non-Hodgkin’s lymphoma.
        Am. J. Clin. Pathol. 1983; 80: 655-659
        • Casper J.T.
        • Lauer S.J.
        • Kirschner P.A.
        • et al.
        Evaluation of cerebrospinal fluid mononuclear cells obtained from children with acute lymphocytic leukemia: Advantages of combining cytomorphology and terminal deoxynucleotidyl transferase.
        Am. J. Clin. Pathol. 1983; 80: 666-670
        • Coleman D.V.
        • To A.
        • Ormerod M.G.
        • et al.
        Immunoperoxidase staining in tumor marker distribution studies in cytologic specimens.
        Acta Cytol. 1981; 10: 205-206
        • Coleman M.S.
        • Greenwood M.F.
        • Hutton J.J.
        • et al.
        Serial observations on terminal deoxnucleotidyl transferase activity and lymphoblastic surface markers in acute lym¬phoblastic leukemia.
        Cancer Res. 1976; 36: 120
        • Collins V.P.
        Monoclonal antibodies to glial fibrillary acidic protein in the cytologic diagnosis of brain tumors.
        Acta Cytol. 1984; 28: 401-406
        • Cordell J.L.
        • Falini B.
        • Erber W.N.
        • et al.
        Immunoenzymatic labeling of monoclonal antibodies using immune complexes of alkaline phosphatase and monoclonal anti-alkaline phosphatase (APAAP complexes).
        J. Histochem. Cytochem. 1984; 32: 219-229
        • Corson J.M.
        • Pinkus G.S.
        Mesothelioma: Profile of keratin proteins and carcinoembryonic antigen: An immunoperoxidase study of 20 cases and comparison with pulmonary adenocarcinomas.
        Am. J. Pathol. 1982; 108: 80-87
        • Cossman J.
        • Neckers L.M.
        • Hsu S.M.
        • et al.
        Low grade lymphomas: Expression of developmentally regulated B cell antigens.
        Am. J. Pathol. 1984; 115: 117-124
        • DeLellis R.A.
        • Sternberger L.A.
        • Mann R.B.
        • et al.
        Immunoperoxidase techniques in diagnostic pathology.
        Am. J. Clin. Pathol. 1979; 71: 483-488
        • DiStefano A.
        • Tashima C.K.
        • Fritsche H.A.
        Carcinoembryonic antigen levels in malignant pleural fluids obtained from patients with mammary cancer.
        Am. J. Clin. Pathol. 1980; 73: 386-389
        • Dulbecco R.
        • Unger M.
        • Bologna M.
        • et al.
        Cross reactivity between Thy-1 and a component of intermediate filaments demonstrated using a monoclonal antibody.
        Nature. 1981; 292: 772-774
        • Eng L.F.
        • Rubinstein L.J.
        Contribution of immunohistochemistry to diagnostic problems of human cerebral tumors.
        J. Histochem. Cytochem. 1978; 20: 513-522
        • Epenetos A.A.
        • Canti G.
        • Taylor-Papadimitriou J.
        • et al.
        Use of two epithelium-specific monoclonal antibodies for diagnosis of malignancy in serous effusions.
        Lancet. 1982; 2: 1004-1006
        • Erlandson R.A.
        Diagnostic immunohistochemistry of human tumors: An interim evaluation.
        Am. J. Surg. Pathol. 1984; 8: 615-624
        • Falini B.
        • Taylor C.R.
        New developments in immunoperoxidase techniques and their application.
        Arch. Pathol Lab. Med. 1983; 107: 105-117
        • Faravelli B.
        • D’Amore E.
        • Nosenzo M.
        • et al.
        Carcinoembryonic antigen in pleural effusions: Diagnostic value in malignant mesothelioma.
        Cancer. 1984; 53: 1194-1197
        • Fenoglio C.M.
        • Tlamsa G.
        Application of immunoperoxidase techniques to diagnostic surgical pathology.
        N.Y. State J. Med. 1983; 3: 293-299
        • Fishleder A.J.
        • Tubbs R.R.
        • Savage R.A.
        • et al.
        Immunophenotypic characterization of acute leukemia by immunocytology.
        Am. J. Clin. Pathol. 1984; 81: 611-617
        • Foon K.A.
        • Schroff R.W.
        • Gale R.P.
        Surface markers on leukemia and lymphoma cells: Recent advances.
        Blood. 1982; 60: 1-19
        • Gattrer K.C.
        • Cordell J.L.
        • Falini B.
        • et al.
        Monoclonal antibodies in diagnostic pathology: Techniques and applications.
        J. Biol. Response Modif. 1983; 2: 369-395
        • Ghosh A.K.
        • Mason D.Y.
        • Spriggs A.I.
        Immunocytochemical staining with monoclonal antibodies in cytologically “negative” serous effusions from patients with malignant disease.
        J. Clin. Pathol. 1983; 36: 1150-1153
        • Ghosh A.K.
        • Spriggs A.I.
        • Taylor-Papadimitriou J.
        • et al.
        Immunocytochemical staining of cells in pleural and peritoneal effusions with a panel of monoclonal antibodies.
        J. Clin. Pathol. 1983; 36: 1154-1164
        • Giorno R.
        A comparision of two immunoperoxidase staining methods based on the avidin-biotin interaction.
        Diagn. Immunol. 1984; 2: 161-166
        • Goodson J.D.
        • Strauss G.M.
        Diagnosis of lymphomatous leptomeningitis by cerebrospinal fluid lymphocyte cell surface markers.
        Am. J. Med. 1979; 66: 1057-1059
        • Guesdon J.L.
        • Ternynck T.
        • Avrameas S.
        The use of avidin-biotin interaction in immunoenzymatic techniques.
        J. Histochem. Cytochem. 1979; 27: 1131-1139
        • Herbert A.
        • Gallagher P.J.
        Interpretation of pleural biopsy biopsy specimens and aspirates with the immunoperoxidase technique.
        Thorax. 1982; 37: 822-827
        • Heyderman E.
        • Steele K.
        • Ormerod M.G.
        A new antigen on the epithelial membrane: Its immunoperoxidase localization in normal and neoplastic tissue.
        J. Clin. Pathol. 1979; 32: 35-39
        • Holden J.
        • Churg A.
        Immunohistochemical staining for keratin and carcinoembryonic antigen in the diagnosis of malignant mesothelioma.
        Am. J. Surg. Pathol. 1984; 8: 277-279
        • Horowitz A.T.
        • Fuks Z.
        • Okon E.
        • et al.
        The use of carcinoembryonic antigen for identification of human tumor cells in malignant effusions.
        Oncology. 1983; 40: 18-25
        • Hsu S.M.
        • Raine L.
        • Fanger H.
        Use of avidin-biotin-peroxidase (ABC) in immunoperoxidase techniques: A comparison between ABC and unlabeled antibody (PAP) procedures.
        J. Histochem. Cytochem. 1981; 29: 577-580
        • Kaplow L.S.
        Substitute for benzidine in myeloperoxidase stains.
        Am. J. Clin. Pathol. 1974; 63: 451
        • Khoo S.K.
        • Hill R.
        • Mackay E.V.
        Carcinoembryonic antigen in ovarian cancer: Correlation of concentrations in tumor tissue, cyst fluid, ascitic fluid and peripheral blood.
        Aust. N.Z. J. Obstet. Gynaecol. 1982; 22: 65-70

      40. Kjeldsberg, C. R., and Knight, J. A.: Body Fluids: Laboratory Examination of Amniotic, Cerebrospinal, Seminal, Synovial and Serous fluids: A Textbook Atlas. Edition 2. Chicago, American Society of Clinical Pathologists. In press.

        • Kjeldsberg C.R.
        • Wilson J.F.
        • Berard C.W.
        Non-Hodgkin’s lymphoma in children.
        Hum. Pathol. 1983; 14: 612-627
        • Klockars M.
        • Lindgren J.
        • Pettersson T.
        Carcinoembryonic antigen in pleural effusions: A diagnostic and prognostic indicator.
        Eur. J. Cancer. 1980; 16: 1149-1152
        • Kobayashi T.K.
        • Yamaki T.
        • Yoshino E.
        • et al.
        Immunocytochemical demonstration of carcinoembryonic antigen in cerebrospinal fluid with carcinomatous meningitis from rectal cancer.
        Acta Cytol. 1984; 28: 430-434
        • Kuroki M.
        • Koga Y.
        • Matsuoka Y.
        Purification and characterization of carcinoembryonic antigen in normal adult feces.
        Cancer Res. 1981; 41: 713-720
        • Lane D.
        • Koprowski H.
        Molecular recognition and the future of monoclonal antibodies.
        Nature. 1982; 296: 200-202
        • Leder L.D.
        The selective enzymocytochemical demonstration of neutrophil myeloid cells and tissue mast cells in paraffin sections.
        Klin. Wochenscr. 1964; 42: 553
        • Martin S.E.
        • Zhang H.Z.
        • Magyarosy E.
        • et al.
        Immunologic methods in cytology: Definitive diagnosis of non-Hodgkin’s lymphomas using immunologic markers for T- and B-cells.
        Am. J. Clin. Pathol. 1984; 82: 666-673
        • Martinez-Vea A.
        • Gatell J.M.
        • Segura F.
        • et al.
        Diagnostic value of tumoral markers in serous effusions: Carcinoembryonic antigen, alpha-1 acidglycoprotein, alpha-fetoprotein, phosphohexose isomerase, and beta2-microglobulin.
        Cancer. 1982; 50: 1783-1788
        • Marty J.
        • Kjeldsberg C.R.
        • Groo S.
        Improved immunoperoxidase stain on frozen sections: An avidin-biotin-peroxidase complex (ABC) technique.
        J. Histotechnol. 1982; 5: 61-64
        • Mason D.Y.
        • Farrell C.
        • Taylor C.R.
        The detction of intracellular antigens in human leukocytes by immunoperoxidase staining.
        Br. J. Haematol. 1975; 31: 361-370
        • Matsuda M.
        • McMurria H.
        • Van Hale P.
        • et al.
        CSF findings in primary lymphoma of the CNS.
        Arch. Neurol. 1981; 38: 397
        • McKenna J.M.
        • Chandvasekhav A.J.
        • Henkin R.E.
        Diagnostic value of carcinoembryonic antigen in exudative pleural effusions.
        Chest. 1980; 78: 587-590
        • Mukai K.
        • Rosa J.
        Applications of immunoperoxidase techniques in surgical pathology.
        in: Fenoglio C.M. Wolff M. Progress in Surgical Pathology. Volume 1. Masson Publications USA, New York1980: 15-49
        • Nadji M.
        The potential value of immunoperoxidase techniques in diagnostic cytology.
        Acta Cytol. 1930; 24: 442-447
        • Osborn M.
        • Weber K.
        Biology of disease: Tumor diagnosis by intermediate filamenttyping: A novel tool for surgical pathology.
        Lab. Invest. 1983; 48: 372-394
        • Primus F.J.
        • Goldenberg D.M.
        Functional histopathology of cancer: A review of immunoenzyme histochemistry.
        Methods Cancer Res. 1982; 20: 139-182
        • Ramaekers F.
        • Haag D.
        • Jap P.
        • et al.
        Immunochemical demonstration of keratin and vimentin in cytologic aspirates.
        Acta Cytol. 1984; 28: 385-392
        • Rittgers R.S.
        • et al.
        Carcinoembryonic antigen levels in benign and malignant pleural effusions.
        Ann. Intern. Med. 1978; 88: 831-834
        • Ritz J.
        • Nadler L.M.
        • Bhian A.K.
        Expression of common acute lymphoblastic leukemia antigen (CALIA) by lymphomas of B-cell and T-cell lineage.
        Blood. 1981; 58: 648-652
        • Said J.W.
        • Nash G.
        • Tepper G.
        • et al.
        Keratin proteins and carcinoembryonic antigen in lung carcinoma: An immunoperoxidase study of fifty-four cases, with ultrastructural correlations.
        Hum. Pathol. 1983; 14: 70-76
        • Sandhaus L.M.
        • Gajl-Peczalska K.J.
        • Brunning R.D.
        Immunophenotyping of leukemia: An immunoperoxidase method using air-dried smears.
        Br. J. Haematol. 1984; 56: 131-138
        • Sarkar S.
        • Chang H.C.
        • Porreco R.P.
        • et al.
        Neural origin of cells in amniotic fluid.
        Am. J. Obstet. Gynecol. 1980; 136: 67
        • Sheibani K.
        • Tubbs R.R.
        Enzyme immunohistochemistry: Technical aspects.
        Semin. Diagn. Pathol. 1984; 1: 235-250
        • Sloane J.P.
        • Ormerod M.G.
        • Carter R.L.
        • et al.
        An immunocytochemical study of the distribution of epithelial membrane antigen in normal and disordered squamous epithelium.
        Diagn Histol. 1982; 5: 11-17
        • Sternberger L.A.
        Immunocytochemistry.
        Edition 2. John Wiley and Sons, New York1979
        • Streefkerk J.G.
        Inhibition of erythrocyte pseudoperoxidase activity by treatment with hydrogen peroxide following methanol J.
        Histochem. Cytochem. 1972; 20: 829-831
        • Svenberg T.
        Carcinoembryonic antigen-like substances of human bile: Isolation and partial characterization.
        Int. J. Cancer. 1976; 17: 588-598
        • Taylor C.R.
        Immunohistologic studies of lymphoma: Past, present, and future.
        J. Histochem. Cytochem. 1980; 28: 777-787
        • To A.
        • Coleman D.V.
        • Dearnaley D.P.
        • Ormerod M.G.
        • et al.
        Use of antisera to epithelial membrane antigen for the cytodiagnosis of malignancy in serous effusions.
        J. Clin. Pathol. 1981; 34: 1326-1332
        • To A.
        • Dearnaley D.P.
        • Ormerod M.G.
        • et al.
        Epithelial membrane antigen: Its use in the cytodiagnosis of malignancy in serous effusions.
        Am. J. Clin. Pathol. 1982; 78: 214-219
        • Tsutsumi Y.
        • Nagura H.
        • Watanabe K.
        Immunohistochemical observations of carcinoembryonic antigen (CEA) and CEA-related substances in normal and neoplastic pancreas: Pitfalls and caveats in CEA immunohistochemistry.
        Am. J. Clin. Pathol. 1984; 82: 535-542
        • Tubbs R.R.
        • Shribani K.
        Immunohistology of lymphoproliferative disorders.
        Semin. Diagn. Pathol. 1984; 1: 272-284
        • Van Belle P.
        Kinetics and Inhibition of alkaline phosphatases from canine tissues.
        Riochim. Biophys. Acta. 1972; 289: 158
        • Vladutiu A.O.
        • Adler R.H.
        • Brason F.W.
        Diagnostic value of biochemical analysis of pleural effusions: Carcinoembryonic antigen and beta 2 microglobulin.
        Am. J. Clin. Pathol. 1979; 71: 210-214
        • Vladutiu A.O.
        • Brason F.W.
        • Adler R.H.
        Differential diagnosis of pleural effusions: Clinical usefulness of cell marker quantitation.
        Chest. 1981; 79: 297-301
        • Von Kleist S.
        • Chavanel G.
        • Burtin P.
        Identification of a normal antigen that crossreacts with carcinoembryonic antigen.
        Proc. Natl. Acad. Sci. U.S.A. 1972; 69: 2492-2494
        • Von Koskull H.
        Rapid identification of glial cells in human amniotic fluid with indirect immunofluorescence.
        Acta Cytol. 1984; 28: 393-400
        • Walts A.E.
        • Said J.W.
        Specific tumor markers in diagnostic cytology: Immunoperoxidase studies of carcinoembryonic antigen, lysozyme and other tissue antigens in effusions, washes and aspirates.
        Acta Cytol. 1983; 27: 408-416
        • Walts A.E.
        • Said J.W.
        • Banks-Schiegel S.
        Keratin and carcinoembryonic antigen in exfoliated mesothelial and malignant cells: An immunoperoxidase study.
        Am. J. Clin. Pathol. 1983; 80: 671-676
        • Walts A.E.
        • Said J.W.
        • Shintaku I.P.
        • et al.
        Keratins of different molecular weight in exfoliated mesothelial and adenocarcinoma cells—an aid to cell identification.
        Am. J. Clin. Pathol. 1984; 81: 442-446
        • Wasserstrom W.R.
        • Schwartz M.K.
        • Fleischer M.
        • et al.
        Cerebrospinal fluid biochemical markers in central nervous system tumors: A review.
        Ann. Clin. Lab. Sci. 1980; 11: 239-251
        • Wood G.S.
        • Link
        • Warnke R.A.
        • et al.
        Pan-leukocyte monoclonal antibody L3B12: Characterization and application to research and diagnostic problems.
        Am. J. Clin. Pathol. 1984; 81: 176-183
        • Wood G.S.
        • Warnke R.
        Suppressioin of endogenous avidin-binding activity in tissues and its relevance to biotin-avidin detection systems.
        J. Histochem. Cytochem. 1981; 29: 1196-1204
        • Yam L.T.
        • Li C.Y.
        • Crosby W.H.
        Cytochemical identification of monocytes and granulocytes.
        Am. J. Clin. Pathol. 1971; 55: 283-290
        • Yam L.T.
        • Winkler C.F.
        Immunocytochemical diagnosis of oat-cell carinoma in pleural effusion.
        Acta Cytol. 1984; 28: 425-429

      Article info

      Identification

      DOI: https://doi.org/10.1016/S0272-2712(18)30868-0

      Copyright

      © 1985 Elsevier Inc. Published by Elsevier Inc. All rights reserved.

      ScienceDirect

      Access this article on ScienceDirect

      The content on this site is intended for healthcare professionals.


      We use cookies to help provide and enhance our service and tailor content. To update your cookie settings, please visit the Cookie Preference Center for this site.
      Copyright © 2023 Elsevier Inc. except certain content provided by third parties.


      RELX