Research Article| Volume 7, ISSUE 1, P181-198, March 1987

Tumors of Schwann’s Cells and Pigmented Skin Cells

  • Janet M. Bruner
    Corresponding Author: M.D. Anderson Hospital and Tumor Institute, Texas Medical Center, 6723 Bertner Avenue, Box 85, Houston, Texas 77030.
    Assistant Professor of Pathology and Chief, Section of Neuropathology, MD Anderson Hospital and Tumor Institute, The University of Texas System Cancer Center, Houston, Texas
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      Both melanocytes and peripheral nerve sheath cells have an established origin from the neural crest. Benign and malignant neoplasms of these cells have distinctive ultra-structural features, but there is a group of tumors that has some characteristics of both cell types. The distinguishing feature of melanocytic neoplasms is the presence of cytoplasmic premelanosomes, which indicates cellular synthesis of melanin. Nerve-sheath neoplasms may show ultrastruc- tural variation, but are generally found to have long cell processes associated with basal lamina-like material. Immunocytochemistry can be used to help distinguish tumors of melanocytic and Schwann’s cells from unrelated neoplasms.
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