Advertisement
Research Article| Volume 7, ISSUE 1, P1-30, March 1987

The Use of Electron Microscopy and Immunohistochemistry in the Diagnosis and Understanding of Lung Neoplasms

  • Samuel Hammar
    Correspondence
    Corresponding Author: Department of Pathology, The Mason Clinic, 1100 Ninth Avenue, Seattle, Washington 98111.
    Affiliations
    Staff Pathologist, Department of Pathology, The Mason Clinic, Seattle, Washington
    Search for articles by this author
DOI:https://doi.org/10.1016/S0272-2712(18)30760-1
The Use of Electron Microscopy and Immunohistochemistry in the Diagnosis and Understanding of Lung Neoplasms
Previous ArticlePreface
Next ArticleTumors of Serosal Tissue Origin
      This paper is only available as a PDF. To read, Please Download here.
      This article describes the ultrastructural and immunohistochemical features of lung neoplasms. It shows how these features can be used to help diagnose and accurately classify lung tumors.
      To read this article in full you will need to make a payment

      Purchase one-time access:

      Academic & Personal: 24 hour online accessCorporate R&D Professionals: 24 hour online access
      One-time access price info
      • For academic or personal research use, select 'Academic and Personal'
      • For corporate R&D use, select 'Corporate R&D Professionals'

      Subscribers receive full online access to your subscription and archive of back issues up to and including 2002.

      Content published before 2002 is available via pay-per-view purchase only.

      Subscribe:

      Subscribe to Clinics in Laboratory Medicine
      Already a print subscriber? Claim online access
      Already an online subscriber? Sign in
      Register: Create an account
      Institutional Access: Sign in to ScienceDirect

      References

        • Afzelius B.A.
        Glycocalyx and glycocalyceal bodies in the respiratory epithelium of nose and bronchi.
        Ultrastruct Pathol. 1984; 7: 1-8
        • Akhtar M.
        • Ali M.A.
        • Owen E.W.
        Application of electron microscopy to the interpretation of fine-needle aspiration biopsies.
        Cancer. 1981; 48: 2458-2463
        • Alvarez-Rernandez E.
        • Folque-Gomez E.
        Atypical bronchial carcinoid with oncocytic features.
        Arch Pathol Lab Med. 1981; 105: 428-431
      4. American Cancer Society Facts and Figures.
        Cancer. 1985; 35: 26-64
        • Barnes L.
        Intestinal-type adenocarcinoma of the nasal cavity and paranasal sinuses.
        Am J Surg Pathol. 1986; 10: 192-202
        • Basset F.
        • Soler P.
        • Wyllie L.
        • et al.
        Langerhans cells in a bronchioloalveolar tumor of lung.
        Virchows Arch (Pathol Anat). 1974; 362: 315-330
        • Becker N.H.
        • Soifer L.
        Benign clear cell tumor (“sugar tumor”) of the lung.
        Cancer. 1971; 27: 712-719
        • Bolen J.W.
        • Thorning D.
        Histogenetic classification of pulmonary carcinomas. Peripheral adenocarcinomas studied by light microscopy, histochemistry and electron microscopy.
        in: Sommers S.C. Rosen P.P. Pathology Annual. Appleton-Century-Crofts, Norwalk1982: 77-100
        • Bone R.C.
        • Balk P.
        Staging of bronchogenic carcinoma.
        Chest. 1982; 82: 473-480
        • Carter D.
        Small-cell carcinoma of the lung.
        Am J Surg Pathol. 1983; 8: 787-796
        • Cebelin M.S.
        Melanocytic bronchial carcinoid tumor.
        Cancer. 1980; 46: 1843-1848
        • Churg A.
        The fine structure of large cell undifferentiated carcinoma of the lung. Evidence for its relation to squamous cell carcinomas and adenocarcinomas.
        Hum Pathol. 1978; 9: 143-156
        • Dail D.H.
        • Liebow A.A.
        • Gmelich J.T.
        • et al.
        Intravascular, bronchiolar, and alveolar tumor of the lung (IVBAT). An analysis of twenty cases of a peculiar sclerosing endothelial tumor.
        Cancer. 1983; 51: 452-464
        • Falor W.H.
        • Ward R.M.
        • Brezler M.R.
        Diagnosis of pleural effusions by chromosome analysis.
        Chest. 1982; 81: 193-197
        • Furukawa T.
        • Watanabe S.
        • Kodama T.
        • et al.
        T-zone histiocytes in adenocarcinoma of the lung in relation to postoperative prognosis.
        Cancer. 1985; 56: 2651-2656
        • Gibbs F.A.
        Lymphoma versus carcinoma.
        JAMA. 1979; 242: 514
        • Gillespie J.J.
        • Luger A.M.
        • Callaway L.A.
        Peripheral spindled cell carcinoid tumor: A review of its ultrastructure, differential diagnosis and biologic behavior.
        Hum Pathol. 1979; 10: 601-606
        • Gould V.E.
        • Linnoila R.L.
        • Memoli V.A.
        • Warren W.H.
        Biology of disease. Neuroendocrine components of the bronchopulmonary tract: Hyperplasias, dysplasias and neoplasms.
        Lab Invest. 1983; 49: 519-573
        • Gould V.E.
        • Linnoila R.L.
        • Memoli V.A.
        • Warren W.H.
        Neuroendocrine cells and neuroen docrine neoplasms of the lung.
        in: Sommers S.C. Rosen P.P. Pathology Annual. Appleton-Century-Crofts, Norwalk1983: 287-330
        • Hammar S.P.
        • Bartha M.
        • Riecks L.
        • Bockus D.
        Technical aspects of thin-needle aspiration biopsy.
        Lab Med. 1980; 11: 227-231
        • Hammar S.P.
        • Bockus D.
        • Remington F.
        • et al.
        Langerhans cells and serum precipitating antibodies against fungal antigens in bronchioloalveolar cell carcinomas; Possible association with eosinophilic granuloma.
        Ultrastruct Pathol. 1980; 1: 19-37
        • Hammar S.P.
        • Bockus D.
        • Remington F.
        • Bartha M.
        The widespread distribution of Langerhans cells in pathologic tissues: An ultrastructural and immunohistochemical study.
        Hum Pathol. 1986; 17: 894-905
        • Hammar S.P.
        • Bockus D.
        • Wheelis R.F.
        • Hill L.
        Electron microscopic studies of undifferentiated lung tumors.
        Chest. 1977; 72: 400
        • Hammar S.
        • Bolen J.W.
        • Bockus D.
        • et al.
        Ultrastructure and immunohistochemical features of common lung tumors: An overview.
        Ultrastruct Pathol. 1985; 9: 283-318
        • Herrera G.A.
        • Alexander C.B.
        • de Moraes H.P.
        Ultrastructural subtypes of pulmonary adenocarcinomas. Correlation with patient survival.
        Chest. 1983; 84: 581-586
        • Horie A.
        • Ohta M.
        Ultrastructural features of large cell carcinoma of the lung with reference to the prognosis in patients.
        Hum Pathol. 1981; 12: 423-432
        • Hsu S.M.
        • Raine L.
        • Fänger H.
        Use of avidin-biotin-peroxidase complex (ABC) in immunoperoxidase techniques: A comparison between ABC and unlabeled antibody (PAP) procedures.
        J Histochem Cytochem. 1981; 29: 577-580
        • Katzenstein A.A.
        • Prioleau P.G.
        • Askin F.B.
        The histologic spectrum and significance of clear cell change in lung carcinoma.
        Cancer. 1980; 45: 943-947
        • Leong A.S.-Y.
        The relevance of ultrastructural examination in the classification of primary lung tumors.
        Pathol. 1982; 14: 37-46
        • Mackay B.
        • Osborne B.M.
        • Wilson R.A.
        Ultrastructure of lung carcinomas.
        in: Straus M.J. The Diagnosis and Treatment of Lung Carcinoma. Grune and Stratton, New York1977: 71-95
        • Mark E.J.
        • Quay S.C.
        • Dickersin G.R.
        Papillary carcinoid tumors of the lung.
        Cancer. 1981; 48: 316-324
        • Roggli V.L.
        • Vollmer R.T.
        • Greenberg S.D.
        • et al.
        Lung cancer heterogeneity: A blinded and randomized study of 100 consecutive cases.
        Hum Pathol. 1985; 16: 569-579
        • Sajjad S.M.
        • Mackay B.
        • Lukeman J.M.
        Oncocytic carcinoid tumor of the lung.
        Ultrastruct Pathol. 1980; 1: 171-176
        • Sidhu G.S.
        The ultrastructure of malignant epithelial neoplasms of the lung.
        in: Sommers S.C. Rosen P.P. Pathology Annual. Appleton-Century-Crofts, Norwalk1982: 235-266
        • Singh G.
        • Katyal S.L.
        • Torikata C.
        Carcinoma of type II pneumocytes. Immunodiagnosis of a subtype of bronchioalveolar carcinomas.
        Am J Pathol. 1981; 102: 195-208
      36. The World Health Organization histological typing of lung tumors.
        Am J Clin Pathol. 1982; 77: 123-136
        • Torikata C.
        • Ishiwata K.
        Intranuclear tubular structures observed in the cells of alveolar cell carcinomas of the lung.
        Cancer. 1977; 40: 1194-1201
        • Unger K.M.
        • Raber M.
        • Bedrossian C.W.M.
        • et al.
        Analysis of pleural effusions using automated flow cytometry.
        Cancer. 1983; 52: 873-877
        • Valaitis J.
        • Warren S.
        • Gamble D.
        Increasing incidence of adenocarcinoma of the lung.
        Cancer. 1981; 47: 1042-1046
        • Vincent R.G.
        • Pickren J.W.
        • Lane W.W.
        • et al.
        The changing histopathology of lung cancer. A review of 1682 cases.
        Cancer. 1977; 39: 1647-1655
        • Vosika G.J.
        Large cell bronchogenic carcinoma. Prolonged disease-free survival following chemotherapy.
        JAMA. 1979; 241: 594-595
        • Vosika G.J.
        Large cell-small cell bronchogenic carcinoma.
        JAMA. 1979; 242: 1258-1259
        • Yesner R.
        Classification of lung cancer histology.
        N Engl J Med. 1985; 312: 652-653
        • Yesner R.
        Small cell tumors of the lung.
        Am J Surg Pathol. 1983; 7: 775-786

      Article info

      Identification

      DOI: https://doi.org/10.1016/S0272-2712(18)30760-1

      Copyright

      © 1987 Elsevier Inc. Published by Elsevier Inc. All rights reserved.

      ScienceDirect

      Access this article on ScienceDirect
      We use cookies to help provide and enhance our service and tailor content. To update your cookie settings, please visit the for this site.
      Copyright © 2023 Elsevier Inc. except certain content provided by third parties. The content on this site is intended for healthcare professionals.


      RELX