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Research Article| Volume 7, ISSUE 3, P641-653, September 1987

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Laboratory Detection of Cannabinoids

DOI:https://doi.org/10.1016/S0272-2712(18)30736-4
Laboratory Detection of Cannabinoids
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      The number of methods available for laboratory detection of cannabinoids is constantly increasing. This article reviews the chemistry and metabolism of marijuana, recent developments in analytic methods, and current therapeutic applications of cannabinoids.
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      References

        • Abercrombie M.L.
        • Jewell J.S.
        Evaluation of Emit and RIA high volume test procedures for THC metabolites in urine utilizing GC/MS confirmation.
        J Anal Toxicol. 1986; 10: 178-180
        • Agurell S.
        • Hallidin M.
        • Lingren J.
        • et al.
        Pharmacokinetics and metabolism of Δ9-tetrahydrocannabinol and other cannabinoids with emphasis on man.
        Pharm Rev. 1986; 38: 21-43
        • Alburges M.E.
        • Peat M.A.
        Profiles of Δ9-tetrahydrocannabinol metabolites in urine of marijuana users: Preliminary observations by high performance liquid chromatography-radioimmunoassay.
        J Forensic Sci. 1986; 31: 695-706
        • Baker T.S.
        • Harry J.V.
        • Russell J.W.
        • et al.
        Rapid method for the GC/MS confirmation of 11-nor-9-carboxy-Δ9-tetrahydrocannabinol in urine.
        J Anal Toxicol. 1984; 8: 255-259
        • Baselt R.C.
        Unusually high cannabinoid concentrations in urine.
        J Anal Toxicol. 1985; 8: 16A
        • Childs P.S.
        • McCurdy H.H.
        Evaluation of a radioimmunoassay (1251) kit for cannabinoid metabolites in urine and whole blood.
        J Anal Toxicol. 1984; 8: 220-223
        • Cohen S.
        Therapeutic aspects.
        in: Peterson R.C. NIDA Research Monograph 14. Marijuana Research Findings: 1976. US Govt. Printing Office, Washington DC1977: 194-225
        • Cook C.E.
        • Seltzman H.H.
        • Schindler V.H.
        • et al.
        Radioimmunoassay for Δ9-tetrahydrocan-nabinol.
        in: Hawks R.L. Analysis of Cannabinoids in Biological Fluids. US Govt. Printing Office, Rockville, Maryland1982 (NIDA Research Monograph No. 42.)
        • Cridland J.S.
        • Rottanburg D.
        • Robins A.H.
        Apparent half-life of excretion of cannabinoids in man.
        Human Toxicol. 1983; 2: 641-644
        • Dackis C.A.
        • Pottash A.L.C.
        • Annito W.
        • et al.
        Persistence of urinary marijuana levels after supervised abstinence.
        Am J Psychiatry. 1982; 139: 1196-1198
        • Dalzell A.M.
        • Bartlett H.
        • Lilleyman J.J.
        Nabilone: An alternate antiemetic for cancer chemotherapy.
        Arch Dis Child. 1986; 61: 502-505
        • DeLaurentis M.J.
        • McNeil K.
        • Mann A.J.
        • et al.
        An EMIT assay for cannabinoid metabolites in urine.
        in: Hawks R.L. The Analysis of Cannabinoids in Biological Fluids. NIDA Research Monograph 42. US Govt. Printing office, Rockville, Maryland1982: 69-84
        • Dewey W.L.
        Cannabinoid pharmacology.
        Pharm Rev. 1986; 38: 151-178
        • Dupont Technical Note
        Use of the Prep A extraction cartridge for confirmation of Δ9-THC by gas chromatography. Dupont Clinical and Instruments Division, Wilmington1983
        • Ellis G.M.
        • Mann M.A.
        • Judson B.A.
        • et al.
        Excretion patterns of cannabinoid metabolites after last use in a group of chronic users.
        Clin Pharmacol Ther. 1985; 38: 572-578
        • Elsohly M.A.
        • Arafat E.S.
        • Jones A.B.
        Analysis of the major metabolite of Δ9-tetrahydrocan-nabinol in urine. III. A GD/ECD procedure.
        J Anal Toxicol. 1984; 8: 7-9
        • Elsohly M.A.
        • Elsohly H.N.
        • Jones A.B.
        • et al.
        Analysis of the major metabolite of Δ9-tetrahydrocannabinol in urine. II. A HPLC prodecure.
        J Anal Toxicol. 1983; 7: 262-264
        • Elsohly M.A.
        • Jones A.B.
        • Elsohly H.N.
        • et al.
        Analysis of the major metabolite of Δ9-tetrahydrocannabinol in urine. VI. Specificity of the assay with respect to indole carboxylic acids.
        J Anal Toxicol. 1985; 9: 190-191
        • Foltz R.L.
        Analysis of cannabinoids in physiological specimens by gas chromatography/mass spectrometry.
        in: Basett R.C. Advances in Analytical Toxicology. Volume 1. Biomedical Publications, Foster City, California1984: 125-157
        • Foltz R.L.
        • McGinnis K.M.
        • Chinn D.M.
        Quantitative measurements of Δ9-tetrahydrocan-nabinol and two major metabolites in physiological specimens using capillary column gas chromatography negative ion chemical ionization mass spectrometry.
        Biomed Mass Spec. 1983; 10: 316-323
        • Fredrick D.L.
        • Green J.
        • Fowler M.W.
        Comparison of six cannabinoid metabolite assays.
        J Anal Toxicol. 1985; 9: 116-120
        • Frytak S.
        Metabolic studies of Δ9-tetrahydrocannabinol in cancer patients.
        Cancer Treat Rep. 1984; 68: 1427-1431
        • Ginzburg H.M.
        • Caddock S.G.
        • Hubbard R.
        • et al.
        Characteristics, behaviors, and outcomes for marijuana users seeking treatment in drug abuse treatment program.
        in: Agurell S. Dewey W.L. Willette R.E. The Cannabinoids: Chemical, Pharmacologic, and Therapeutic Aspects. Academic Press, New York1984: 47-59
        • Galen R.S.
        • Gambino S.R.
        Beyond Normality: The Predictive Value and Efficiency of Medical Diagnosis. John Wiley, New York1975
        • Gross S.J.
        • Worthy T.E.
        • Nerder L.
        • et al.
        Detection of recent cannabis use by saliva Δ9-THC radioimmunoassay.
        J Anal Toxicol. 1985; 9: 1-5
        • Hallidin M.M.
        • Carlson S.
        • Kanter S.L.
        • et al.
        Urinary metabolites of AMetrahydrocannabinol in man.
        Arzneimittelforschnung. 1982; 32: 764-767
        • Hallidin M.M.
        • Anderson L.K.B.
        • Widman M.
        • et al.
        Further urinary metabolites of Δ1-tetrahydrocannabinol in man.
        Arzneimittelforschnung. 1982; 32: 1135-1138
        • Herman L.S.
        • Einhorn L.H.
        • Jones S.E.
        • et al.
        Superiority of nabilone over prochlorperazine as an anti-emetic in patients receiving cancer chemotherapy.
        N Engl J Med. 1979; 300: 1295-1297
        • Hollister L.E.
        Structure activity relationships in man of cannabis constituents and homologs and metabolites of Δ9-tetrahydrocannabinol.
        Pharmacology. 1974; 11: 3
        • Hollister L.E.
        • Kanter S.L.
        • Board R.D.
        • et al.
        Marijuana metabolites in urine of man. III. Unchanged Δ9-tetrahydrocannabinol.
        Res Commun Chem Pathol Pharmacol. 1974; 8: 579-584
        • Hollister L.E.
        • Gillespie H.K.
        • Ohlsson A.
        • et al.
        Do plasma concentrations of Δ9-tetrahydrocannabinol reflect the degree of intoxication?.
        J Clin Pharmacol. 1981; 21: 171S-177S
        • Hollister L.E.
        Health aspects of cannabis.
        Pharm Rev. 1986; 38: 1-20
        • Hunt C.A.
        • Jones R.T.
        Tolerance and disposition of tetrahydrocannabinol in man.
        J Pharmacol Exp Ther. 1980; 215: 35-44
        • Irving J.
        • Leeb B.
        • Foltz R.L.
        • et al.
        Evaluation of immunoassays for cannabinoids in urine.
        J Anal Toxicol. 1984; 8: 182-196
        • Isenschmid D.S.
        • Caplan Y.H.
        A method for the determination of 11-norΔ9-tetrahydrocan-nabinol-9-carboxylic acid in urine using high performance liquid chromatography with electrochemical detection.
        J Anal Toxicol. 1986; 10: 170-174
        • Jones A.B.
        • Elsohly H.N.
        • Arafat E.S.
        • et al.
        Analysis of the major metabolite of Δ9-tetrahydrocannabinol in urine. IV. A comparison of five methods.
        J Anal Toxicol. 1984; 8: 249-251
        • Jones A.B.
        • Elsohly H.N.
        • Elsohly M.A.
        Analysis of the major metabolites of Δ9-tetrahydro-cannabinol in urine. V.
        Cross-reactivity of selected compounds in a radioimmunoassay. J Anal Toxicol. 1984; 8: 252-254
        • Kanter S.L.
        • Hollister L.E.
        • Williams M.
        Extraction of glucuronide metabolites of Δ9-tetrahydrocannabinol by diethyl ether.
        J Chromatogr. 1982; 234: 255-260
        • Kanter S.L.
        • Hollister L.E.
        • Zamora J.U.
        Marijuana metabolites in urine of man. XI. Detection of unconjugated and conjugated Δ9-tetrahydrocannabinol-11-oic acid by thin layer chromatography.
        J Chromatogr. 1982; 235: 507-512
        • Karlsson L.
        • Jonsson J.
        • Aberg K.
        • et al.
        Determination of Δ9-tetrahydrocannabinol-ll—oic acid in urine as its pentafluoropropyl-pentafluoroproprionyl derivative by GC/MS utilizing negative ion chemical ionization.
        J Anal Toxicol. 1983; 7: 198-202
        • Karlsson L.
        • Roos C.
        Combination of liquid chromatography with ultraviolet detection and gas chromatography with electron capture detection for determination of Δ9-tetrahydro- cannabinol-11-oic acid urine.
        J Chromatogr. 1984; 306: 183-189
        • King D.L.
        • Machado L.M.
        • Martel P.A.
        • et al.
        Evaluation of a thin layer chromatography (TLC) system for determination of cannabinoids.
        Clin Chem. 1984; 30: 1030
        • Kogan M.J.
        • Newman E.
        • Willson W.J.
        Detection of marijuana metabolite 11-nor-Δ9-tetrahydrocannabinol-9-carboxylic acid in human urine by bonded phase adsorption and thin-layer chromatography.
        J Chromatgr. 1983; 306: 441-443
        • Law B.
        • Mason P.A.
        • Moffat A.C.
        • et al.
        Forensic aspects of the metabolism and excretion of cannabinoids following oral ingestion of cannabis resin.
        J Pharm Pharmacol. 1984; 36: 289-294
        • Law B.
        • Mason P.A.
        • Moffat A.C.
        • et al.
        Passive inhalation of cannabis smoke.
        J Pharm Pharmacol. 1984; 36: 578-581
        • Law B.
        • Mason P.A.
        • Moffat A.C.
        • et al.
        A novel 125I radioimmunoassay for the analysis of Δ9-tetrahydrocannabinol and its metabolites in human body fluids.
        J Anal Toxicol. 1984; 8: 14-17
        • Law B.
        • Mason P.A.
        • Moffat A.C.
        • et al.
        Confirmation of cannabis use by the analysis of Δ9-tetrahydrocannabinol metabolites in blood and urine by combined HPLC and RIA.
        J Anal Toxicol. 1984; 8: 19-22

      48. Martel P, King D, Gabor M, et al: A new Toxi-Lab methodology for cannabinoids. Presented at the Calif Assoc Toxicologist quarterly meeting, Feb 1986

        • Martin B.R.
        Cellular effects of cannabinoids.
        Pharm Rev. 1986; 38: 45-74
        • Mason A.P.
        • Perez-Reyes M.
        • McBay A.J.
        • et al.
        Cannabinoid concentrations in plasma after passive inhalation of marijuana smoke.
        J Anal Toxicol. 1983; 7: 172-174
        • Maykut M.O.
        Health Consequences of Acute and Chronic Marijuana Use. Pergamon Press, New York1984
        • Mechoulam R.
        • Shani A.
        • Edery H.
        • et al.
        The chemical basis of hashish activity.
        Science. 1970; 169: 611-612
        • McBay A.J.
        • Dubowski K.M.
        • Finkle B.S.
        Urine testing for marijuana use.
        JAMA. 1983; 249: 881
        • McBurney L.F.
        • Boobie B.D.
        • Sepp L.A.
        GC/MS and EMIT analysis of Δ9-tetrahydrocanna-binol metabolites in plasma and urine of human subjects.
        J Anal Toxicol. 1986; 10: 56-64
        • McCurdy H.H.
        • Lewellen L.J.
        • Callahan L.S.
        Evaluation of the ion trap detector for the detection of 11-nor-Δ9-THC-9-carboxylic acid in urine after extraction by bonded phase adsorption.
        J Anal Toxicol. 1986; 10: 175-177
        • Morland J.
        • Bugge A.
        • Skuterud B.
        • et al.
        Cannabinoids in blood and urine after passive inhalation of cannabis smoke.
        J Forensic Sci. 1985; 30: 997-1002
        • Ohlsson A.
        • Lindgren J.
        • Wahlen A.
        • et al.
        Plasma Δ9-tetrahydrocannabinol concentrations and clinical effects after oral and intravenous administration and smoking.
        Clin Pharmacol Ther. 1980; 28: 409-416
        • Ohlsson A.
        • Lindgren J.
        • Wahlen A.
        • et al.
        Single dose kinetics of deuterium labeled Δ1-tetrahydrocannabinol in light and heavy cannabis users.
        Biomed Mass Spec. 1982; 9: 6-10
        • Peat M.A.
        The analysis of Δ9-tetrahydrocannabinol and its metabolites by immunoassay.
        in: Baselt R.C. Advances in Analytical Toxicology. Biomedical Publications, Foster City, California1984: 59-80
        • Perez-Reyes M.
        • Timmons M.C.
        • Davis K.H.
        • et al.
        A comparison of the pharmacological activity in man of intravenously administered Δ9-tetrahydro-cannabinol, cannabinol, and cannabidiol.
        Experientia. 1973; 29: 1368
        • Perez-Reyes M.
        • DiGiuseppi S.
        • Mason A.P.
        • et al.
        Passive inhalation of marijuana smoke and urinary excretion of cannabinoids.
        Clin Pharmacol Ther. 1983; 34: 36-41
        • Perez-Reyes M.
        • Owens S.M.
        • DiGiuseppi S.
        The clinical pharmacology and dynamics of marijuana cigarette smoking.
        J Clin Pharmacol. 1981; 21: 201S-207S
        • Razdan R.K.
        Structure activity relationships in cannabinoids.
        Pharm Rev. 1986; 38: 75-149
        • Rosenfeld J.M.
        • McLeod R.A.
        • Foltz R.L.
        Solid support reagents in the determination of cannabinoids in plasma.
        Anal Chem. 1986; 58: 716-721
        • Rogers R.
        • Crowl C.P.
        • Eimstad W.A.
        • et al.
        Homogenous enzyme immunoassay for cannabinoids in urine.
        Clin Chem. 1978; 24: 95-100
        • Schwartz R.H.
        • Hayden G.F.
        • Riddle M.
        Laboratory detection of marijuana use.
        Am J Dis Child. 1985; 139: 1093-1096
        • Sutheimer C.A.
        • Yarborough R.
        • Hepler B.R.
        • et al.
        Detection and confirmation of urinary cannabinoids.
        J Anal Toxicol. 1985; 9: 156-160
        • Swatek R.
        Marijuana use: Persistence and urinary elimination.
        J Subst Abuse Treat. 1984; 1: 265-270
        • Turner C.E.
        Chemistry and Metabolism.
        in: Peterson R.C. NIDA Research Monograph 31. Marijuana Research Findings: 1980. US Govt. Printing Office, Washington DC1980: 81-97
        • Ungerleider J.T.
        • Andrysiak T.
        Therapeutic issues of marijuana and THC (tetrahydrocannabinol).
        Int J Addict. 1985; 20: 691-699
        • Vinson J.A.
        • Lopatofsky D.J.
        A semi-automated extraction and spotting system for drug analysis by TLC.I. Procedure for analysis of the major metabolite of Δ9-tetrahydrocan- nobinol in urine.
        J Anal Toxicol. 1985; 9: 6-9
        • Wall M.E.
        • Sadler B.M.
        • Brine D.
        • et al.
        Metabolism disposition and kinetics of Δ9-tetrahydrocannabinol in men and women.
        Clin Pharm Ther. 1983; 34: 352-363
        • Wall M.E.
        • Perez-Reyes M.
        The metabolism of Δ9-tetrahydrocannabinol and related cannabinoids in man.
        J Clin Pharmacol. 1981; 21: 178S-189S
        • Wall M.E.
        • Brine D.R.
        • Perez-Reyes M.
        The metabolism of cannabinoids in man.
        in: Braude M.C. Szara S. Pharmacology of Marijuana. Raven Press, New York1976: 93-117
        • Williams P.L.
        • Moffat A.C.
        Identification in human urine of Δ9-tetrahydrocannabinol-11-oic acid glucuronide: A tetrahydrocannabinol metabolite.
        J Pharm Pharmacol. 1980; 32: 445-448
        • Whiting J.D.
        • Manders W.W.
        Confirmation of a tetrahydrocannabinol metabolite in urine by gas chromatography.
        J Anal Toxicol. 1982; 6: 49-52
        • Whiting J.D.
        • Manders W.W.
        The confirmation of 9-carboxy-THC in urine by gas chromatography/mass spectrometry.
        Aviat Space Environ Med. 1983; 54: 1031-1033
        • Wong A.S.
        • Orbanowsky M.W.
        • Reeve V.C.
        • et al.
        Stability of Δ9-tetrahydrocannabinol in stored blood and serum.
        in: Hawks R.L. The Analysis of Cannabinoids in Biological Fluids. NIDA Research Monograph 42. US Govt. Printing Office, Washington DC1982: 119-124

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      DOI: https://doi.org/10.1016/S0272-2712(18)30736-4

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      © 1987 Elsevier Inc. Published by Elsevier Inc. All rights reserved.

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