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Research Article| Volume 7, ISSUE 3, P587-606, September 1987

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Cardiac Glycosides

  • Gideon Koren
    Affiliations
    Career Scientist, Ontario Ministry of Health, and Assistant Professor, Departments of Pediatrics and Pharmacology, University of Toronto, Toronto, Ontario, Canada
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  • Steven J. Soldin
    Correspondence
    Steven J. Soldin, PhD, FACB, Department of Biochemistry, The Hospital for Sick Children, 555 University Avenue, Toronto, Ontario M5G 1X8 Canada
    Affiliations
    Professor, Departments of Clinical Biochemistry and Pharmacology, University of Toronto, Ontario, Canada

    Associate Biochemist and Director, Therapeutic Drug Monitoring Program, Hospital for Sick Children, Toronto, Ontario, Canada
    Search for articles by this author
DOI:https://doi.org/10.1016/S0272-2712(18)30733-9
Cardiac Glycosides
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      The metabolism of digoxin is fairly extensive in the majority of patients receiving this drug, and the metabolites possess varying degrees of cardioactivity. Immunoassays measure the parent drug but also cross-react with many cardioin- active metabolites. In addition, many compounds have been shown to interfere with the digoxin immunoassay, further complicating interpretation of results.
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      Article info

      Footnotes

      Supported in part by Grant MA 8544 of The Medical Research Council of Canada and Health and Welfare, Canada

      Portions of this article adapted from Soldin SJ: Digoxin—issues and controversies. Clin Chem 32:5-12, 1986; with permission

      Identification

      DOI: https://doi.org/10.1016/S0272-2712(18)30733-9

      Copyright

      © 1987 Elsevier Inc. Published by Elsevier Inc. All rights reserved.

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