Research Article| Volume 7, ISSUE 3, P499-512, September 1987

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Antimicrobial Susceptibility Tests and Their Role in Therapeutic Drug Monitoring

  • Paola C. DeGirolami
    Corresponding author: Department of Pathology, New England Deaconess Hospital, 185 Pilgrim Road, Boston, Massachusetts 02215
    Assistant Professor, Department of Pathology, Harvard Medical School, and Director of Microbiology, New England Deaconess Hospital, Boston, Massachusetts
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  • George Eliopoulos
    Assistant Professor, Department of Medicine, Harvard Medical School, and Assistant Chairman, Department of Medicine, New England Deaconess Hospital, Boston, Massachusetts
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      Principles and techniques of routine and special in vitro antimicrobial susceptibility testing of bacteria are reviewed with emphasis on the advantages, limitations, and potential problems of each method. The utilities of MBC testing and of serum bactericidal titer determination are discussed in the clinical context. The use of testing for possible antibiotic interactions is examined in light of potential benefits and risks of combination antimicrobial therapy.
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