Advertisement
Research Article| Volume 9, ISSUE 1, P169-186, March 1989

Triglyceride Measurement and Its Relationship to Heart Disease

DOI:https://doi.org/10.1016/S0272-2712(18)30648-6
Triglyceride Measurement and Its Relationship to Heart Disease
Previous ArticleThe Status of Hypertriglyceridemia as a Risk Factor for Coronary Heart Disease
Next ArticleIndex
      This paper is only available as a PDF. To read, Please Download here.
      The role of trigylcerides in atherosclerosis remains controversial, although it may be important in certain population subgroups. The triglyceride-rich lipoproteins play an important role in lipid metabolism. Measurement of plasma triglycerides is important for routine lipid-ather-osclerosis risk assignment. Significantly more attention needs to be focused on standardization of triglyceride measurements in clinical laboratories.
      To read this article in full you will need to make a payment

      Purchase one-time access:

      Academic & Personal: 24 hour online accessCorporate R&D Professionals: 24 hour online access
      One-time access price info
      • For academic or personal research use, select 'Academic and Personal'
      • For corporate R&D use, select 'Corporate R&D Professionals'

      Subscribers receive full online access to your subscription and archive of back issues up to and including 2002.

      Content published before 2002 is available via pay-per-view purchase only.

      Subscribe:

      Subscribe to Clinics in Laboratory Medicine
      Already a print subscriber? Claim online access
      Already an online subscriber? Sign in
      Register: Create an account
      Institutional Access: Sign in to ScienceDirect

      References

        • Ahmed S.
        • Lippel K.
        • Bachorik P.
        • et al.
        External quality control survey of triglyceride (triacylglycerol) analyses performed by 12 lipid research clinics.
        Clin Chem. 1979; 25: 880
        • Albrink M.J.
        • Man E.B.
        Serum-triglycerides in coronary artery disease.
        Arch Intern Med. 1959; 103: 4
        • Antonis A.
        • Bersohn I.
        Serum-triglyceride levels in South African Europeans and Bantu and in ischaemic heart disease.
        Lancet. 1960; 1: 998
        • Ballantyne D.
        • Lawrie T.D.V.
        Hyperlipoproteinemia and peripheral vascular disease.
        Clin Chim Acta. 1973; 47: 269
        • Beyrer K.
        • May R.
        • Sailer S.
        Blutilipide und Glukosetoleranz bei 100 Patienten mit arteriosklerotischem Verschouss anden unteren Extremitaten.
        Wien Klin Wo-chenschr. 1968; 80: 392
        • Bonderman D.P.
        • Proksch G.
        • Bonderman P.W.
        Addition of triglyceride to serum for use in quality control and reference.
        Clin Chem. 1976; 22: 1299
        • Bradley W.A.
        • Gianturco S.H.
        Low density lipoprotein receptor-mediated interactions of triglyceride (TG)-rich lipoproteins.
        in: Fidge N.H. Nestel P.J.S. Atherosclerosis. ed 7. Elsevier Science Publishers, Amsterdam1986: 217
        • Brunzell J.D.
        • Schrott H.G.
        • Motulsky A.G.
        • et al.
        Myocardial infarction in the familial forms of hypertriglyceridemia.
        Metabolism. 1976; 25: 313
        • Bucolo G.
        • David H.
        Quantitative determination of serum triglycerides by the use of enzymes.
        Clin Chem. 1973; 19: 476
        • Cambien F.
        • Jacqueson A.
        • Richard J.L.
        • et al.
        Is the level of serum triglyceride a significant predictor of coronary death in “normocholesterolemic” subjects? The Paris Prospective Study.
        Am J Epidemiol. 1986; 124: 624
        • Canner P.L.
        • Berge K.G.
        • Wenger N.K.
        • et al.
        Fifteen-year mortality in coronary drug project patients: Long-term benefit with niacin.
        J Am Coll Cardiol. 1986; 8: 1245
        • Carlson L.A.
        • Bottiger L.E.
        Risk factors for ischaemic heart disease in men and women.
        Acta Med Scand. 1985; 218: 207
        • Carlson L.A.
        • Bottiger L.E.
        • Ahfeldt P.E.
        Risk factors for myocardial infarction in the Stockholm Prospective Study: A 14-year follow-up focusing on the role of plasma triglycerides and cholesterol.
        Acta Med Scand. 1979; 206: 351
        • Carlson L.A.
        Determination of serum triglycerides.
        J Atherosclerosis Res. 1963; 3: 334
        • Castelli W.P.
        The triglyceride issue: A view from Framingham.
        Am Heart J. 1984; 112: 432
        • Cheung C.K.
        Effect of detergent on triglyceride assay.
        Clin Chem. 1987; 33: 202
        • Chong-Kit R.
        • McLaughlin P.
        Fully automated, all-enzymatic triglyceride method adapted to the Gemsaec centrifugal analyzer, with use of an aequeous triolein standard.
        Clin Chem. 1974; 20: 1454
        • College of American Pathologists
        Comprehensive Set C-A Comprehensive Chemistry Survey.
        Participant Survey. College of American Pathologists, Skokie, Ill1988
        • Committee of Principal Investigators
        A cooperative trial in the primary prevention of ischemic heart disease using clofibrate.
        Br Heart J. 1978; 40: 1069
        • Consensus Development Conference
        Lowering of cholesterol to prevent heart disease.
        JAMA. 1985; 253: 2080
        • Consensus Development Conference
        Treatment of hypertriglyceridemia.
        JAMA. 1984; 251: 1196
        • Cox D.R.
        • Oakes D.
        Analysis of survival data.
        Monographs on Statistics and Applied Probability. Chapman & Hall, Ltd, London1984
        • Davingnon J.
        • Lussier-Cacan S.
        • Ortin-George M.
        • et al.
        Plasma lipids and lipoprotein patterns in angiographically graded atherosclerosis of the legs and in coronary heart disease.
        Can Med Assoc J. 1977; 116: 1245
        • Delong D.V.
        • DeLong E.R.
        • Wood P.D.
        • et al.
        A comparison of methods for the estimation of plasma low- and very low-density lipoprotein cholesterol: The Lipid Research Clinics Prevalence Study.
        JAMA. 1986; 256: 2372
        • Duffield R.G.M.
        • Lewis B.
        • Miller N.E.
        • et al.
        Treatment of hyperlipidemia retards progression of symptomatic femoral atherosclerosis: A randomized controlled trial.
        Lancet. 1983; 2: 639
        • The Expert Panel
        Report of the National Cholesterol Education Program′s Expert Panel on detection, evaluation, and treatment of high blood cholesterol in adults.
        Arch Intern Med. 1988; 148: 36
        • Fager G.
        • Wiklund
        • Olofsson S.O.
        • et al.
        Multivariate analyses of serum apolipoproteins and risk factors in relation to acute myocardial infarction.
        Arteriosclerosis. 1981; 1: 273
        • Fossati P.
        • Prencipe L.
        Serum triglycerides determined colorimetrically with an enzyme that produces hydrogen peroxide.
        Clin Chem. 1982; 28: 2077
        • Frick M.H.
        • Elo O.
        • Haapa K.
        • et al.
        Helsinki Heart Study: Primary prevention trial with gemfibrozil in middle-aged men with dyslipidemia.
        N Engl J Med. 1987; 317: 1237
        • Friedewald W.T.
        • Levy R.I.
        • Fredrickson D.S.
        Estimation of the concentration of low-density lipoprotein cholesterol in plasma without use of the preparative ultracentrifuge.
        Clin Chem. 1972; 18: 499
        • Greenhalgh R.M.
        • Lewis B.
        • Rosengarten D.S.
        • et al.
        Serum lipids and lipoproteins in peripheral vascular disease.
        Lancet. 1971; 2: 947
        • Greenhalgh R.M.
        • Taylor G.W.
        • Kaye J.
        A comparison of fasting lipid concentrations and lipoprotein patterns in patients with stenosing and dilating forms of peripheral arterial disease.
        J Cardiovasc Surg (Torino). 1975; 16: 150
        • Guilmet R.
        • Altaffer M.
        • Statland B.
        • et al.
        Falsely high results for triglycerides in patients receiving intravenous nitroglycerin.
        Clin Chem. 1986; 32: 2098
        • Havel R.J.
        • Eder H.A.
        • Bragdon J.H.
        Distribution and chemical composition of ultracentrifugally separated lipoproteins in human serum.
        J Clin Invest. 1955; 34: 1345
        • Hulley S.B.
        • Rosenman R.H.
        • Bawol R.D.
        • et al.
        Epidemiology as a guide to clinical decisions: The association between triglyceride and coronary heart-disease.
        N Engl J Med. 1980; 302: 1383
        • Kannel W.B.
        • Garcia M.J.
        • McNamara P.M.
        • et al.
        Serum lipid precursors of coronary artery disease.
        Hum Pathol. 1971; 2: 129
        • Kaukola S.
        • Manninen V.
        • Halonen P.I.
        Serum lipids with special reference to HDL cholesterol and triglycerides in young male survivors of acute myocardial infarction.
        Acta Med Scand. 1980; 208: 41
        • Kessler G.
        • Lederer H.
        Fluorometric measurement of triglycerides.
        in: Skeggs L.T. Automation in Analytical Chemistry. Technicon Symposia 1965. Mediad, New York1966: 341
        • Kuckmak M.
        • Taylor L.
        • Olansky A.S.
        Suitability of frozen and lyophilized reference sera for cholesterol and triglyceride determinations.
        Clin Chem Acta. 1982; 120: 261
        • Kukita H.
        • Imamura Y.
        • Hamada M.
        • et al.
        Plasma lipids and lipoproteins in Japanese male patients with coronary artery disease and in their relatives.
        Atherosclerosis. 1982; 42: 21
        • Lipid Research Clinics Program Epidemiology Committee
        Plasma lipid distributions in selected North American population. The Lipid Research Clinics Program Prevalence Study.
        Circulation. 1979; 60: 427
        • Later R.
        • Pegon Y.
        • Contreras P.
        • et al.
        A fluorescent biological compound that can cause error in enzymic triglycerides determination.
        Clin Chem. 1985; 31: 499
        • Luley C.
        • Prellivitz W.
        Qualitative detection of chylomicrons with a high speed laboratory centrifuge compared with 16-h-standing test, lipoprotein electrophoresis, and preparative ultracentrifugation.
        Clin Chem. 1988; 34: 1362

      44. Manual of Laboratory Operations, Lipid Research Clinics Program: Lipid and lipoprotein analysis. U.S. Department of Health and Human Services, Public Health Service, National Institutes of Health, Publication No. 361-132:678, 1982

        • McNeely S.
        • Seatter K.
        • Yuhaniak J.
        • et al.
        The 16 hr standing test and lipoprotein electrophoresis compared for detection of chylomicrons in plasma.
        Clin Chem. 1981; 27: 731
        • McPherson R.A.
        • Brown K.
        • Agarwai R.
        • et al.
        Hydroxylurea interferes negatively with triglyceride measurement by a glycerol oxidase method.
        Clin Chem. 1985; 31: 1355
        • Newell R.G.
        • Bliss B.P.
        Lipoproteins and the relative importance of plasma cholesterol and triglycerides in peripheral arterial disease.
        Angiology. 1973; 24: 297
        • Noble R.D.
        Electrophoretic separation of plasma lipoproteins in agarose gel.
        J Lipid Res. 1968; 9: 693
        • Rautela G.S.
        • Slater S.
        • Arvan D.A.
        Assessment of the need for triglyceride blank measurements.
        Clin Chem. 1973; 19: 1193
        • Rosenman R.H.
        • Brand R.J.
        • Sholtz R.I.
        • et al.
        Multivariate prediction of coronary heart disease during 8.5 year follow-up in the Western Collaborative Group Study.
        Am J Cardiol. 1976; 37: 903
        • Ryder K.
        • Glick M.
        • Bertram S.
        • et al.
        Effect of dry-skin products on Ektachem triglyceride results.
        Clin Chem. 1986; 32: 1410
        • Seidel D.
        • Alaupovic P.
        • Furman R.
        • et al.
        A lipoprotein characterizing obstructive jaundice. II. Isolation and partial characterization of the protein moieties of low density lipoproteins.
        J Clin Invest. 1970; 49: 2396
        • Shepherd J.
        • Caslake M.J.
        • Lorimer A.R.
        • et al.
        Fenofibrate reduces low density lipoprotein catabolism in hypertriglyceridemic subjects.
        Arteriosclerosis. 1985; 5: 162
        • Sirtori C.R.
        • Biasi G.
        • Vercellio G.
        • et al.
        Diet, lipids and lipoproteins in patients with peripheral vascular disease.
        Am J Med Sci. 1974; 268: 325
        • Slack J.
        Risks of ischemic heart disease in familial hyperlipoproteinemic states.
        Lancet. 1969; 2: 1380
        • Spain M.A.
        • Wu A.H.B.
        Bilirubin interference with determination of uric acid, cholesterol and triglycerides in commercial peroxidase-coupled assay, and the effect of ferrocyanide.
        Clin Chem. 1986; 32: 518
        • Stein E.A.
        Lipid, lipoproteins, and apolipoproteins.
        in: Tietz N.W. Textbook of Clinical Chemistry. WB Saunders Co, Philadelphia1986: 829
        • Stein E.A.
        • McNeely S.
        • Steiner P.
        Electrophoretic separation of high-density lipoprotein cholesterol evaluated and compared with the modified lipid research clinic procedure.
        Clin Chem. 1979; 24: 1934
        • Steiner G.
        Diabetes and atherosclerosis: An overview.
        Diabetes. 1981; 30: 1
        • Stokes Y.M.
        • Salmond C.E.
        • Carpenter L.M.
        • et al.
        Stability of total cholesterol, high-den-sity-lipoprotein cholesterol, and triglycerides in frozen sera.
        Clin Chem. 1986; 32: 995
        • Sullivan D.R.
        • Kruijswijk Z.
        • West C.E.
        • et al.
        Determination of serum triglycerides by an accurate enzymatic method not affected by free glycerol.
        Clin Chem. 1985; 31: 1227
        • Tan M.H.
        • Macintosh W.
        • Weldon K.L.
        • et al.
        Serum high density lipoprotein cholesterol in patients with abnormal coronary arteries.
        Atherosclerosis. 1980; 37: 187
        • Tiedink G.M.
        • Katan M.B.
        Frozen storage of serum does not affect cholesterol and triglyceride concentration in lipoproteins as separated by gradient ultracentrifugation.
        Clin Chem. 1988; 34: 593
        • VanHandel E.
        • Zilversmit J.
        Micromethod for the direct determination of serum triglycerides.
        J Lab Clin Med. 1957; 50: 152
        • Walldius G.
        Plasma triglycerides and the development of atherosclerotic disease.
        in: Fidge N.H. Nestel P.J. Atherosclerosis. ed 7. Elsevier Science Publishers, Amsterdam1986: 205
        • Whayne T.F.
        • Alaupovic P.
        • Curry M.D.
        • et al.
        Plasma apolipoprotein B and VLDL-, LDL-, and HDL-cholesterol as risk factors in the development of coronary artery disease in male patients examined by angiography.
        Atherosclerosis. 1981; 39: 411
        • Zilversmit D.B.
        A proposal linking atherogenesis to the interaction of endothelial lipoprotein lipase with triglyceride-rich lipoproteins.
        Circ Res. 1973; 33: 633
        • Zoppi F.
        Single-cuvet sequential determination of triglyceride and cholesterol.
        Clin Chem. 1985; 31: 2036

      Article info

      Identification

      DOI: https://doi.org/10.1016/S0272-2712(18)30648-6

      Copyright

      © 1989 Elsevier Inc. Published by Elsevier Inc. All rights reserved.

      ScienceDirect

      Access this article on ScienceDirect

      The content on this site is intended for healthcare professionals.


      We use cookies to help provide and enhance our service and tailor content. To update your cookie settings, please visit the Cookie Preference Center for this site.
      Copyright © 2023 Elsevier Inc. except certain content provided by third parties.


      RELX