Research Article| Volume 9, ISSUE 1, P37-60, March 1989

The Need for Accurate Total Cholesterol Measurement: Recommended Analytical Goals, Current State of Reliability, and Guidelines for Better Determinations

  • Herbert K. Naito
    Corresponding author: The Cleveland Clinic Foundation, Department of Biochemistry L-1240 1 Clinics Center 9500 Euclid Avenue Cleveland, OH 44194.
    Head, Section of Lipids, Nutrition and Metabolic Diseases, Department of Biochemistry, Division of Laboratory Medicine, The Cleveland Clinic Foundation, Cleveland, Ohio
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      The National Heart, Lung and Blood Institute′s national awareness program on cholesterol and heart disease has produced new demands for more reliable measurements of lipids and lipoproteins. Public awareness and clinicians′ concerns about the reliability of laboratory testing make it paramount that the analytical problems and issues are identified and solutions provided to increase the reliability of measurement of these blood constituents. Assessment of the current state of reliability of cholesterol measurements in clinical laboratories is extensively discussed, and specific recommendations are provided for some of the problems.
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