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Research Article| Volume 9, ISSUE 3, P545-557, September 1989

Syphilis

  • Sandra A. Larsen
    Correspondence
    Corresponding author: Treponemal Pathogenesis and Immunobiology Branch, Sexually Transmitted Diseases Laboratory Program, Center for Infectious Diseases, Centers for Disease Control, Building 1, Room 3329, MS D-13, Atlanta, GA 30333.
    Affiliations
    Chief, Treponemal Pathogenesis and Immunobiology Branch, Sexually Transmitted Diseases Laboratory Program, Center for Infectious Diseases, Centers for Disease Control, Atlanta, Georgia
    Search for articles by this author
DOI:https://doi.org/10.1016/S0272-2712(18)30618-8
Syphilis
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      The clinical manifestations of syphilis can resemble many diseases. The diagnosis can be confirmed through serologic tests and by direct microscopic observation of Treponema pallidum subspecies pallidum in lesion, biopsy, or autopsy specimens. Direct microscopic examination may be carried out by darkfield methods or by immunofluorescent staining. The serologic testing sequence is usually a screening nontreponemal test followed by confirmation with a specific treponemal test. Serologic tests for syphilis have been highly standardized in the past, but today quality control lies in the hands of the laboratorian.
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      Article info

      Footnotes

      All material in this article is in the public domain with the exception of any borrowed tables and figures.

      Identification

      DOI: https://doi.org/10.1016/S0272-2712(18)30618-8

      Copyright

      © 1989 Elsevier Inc. Published by Elsevier Inc. All rights reserved.

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