Research Article| Volume 10, ISSUE 1, P119-149, March 1990

Molecular Genetic Approaches for the Diagnosis of Clonality in Lymphoid Neoplasms

  • Cheryl L. Willman
    Address reprint requests to: Cheryl L. Willman, MD, UNM Center for Molecular and Cellular Diagnostics, University of New Mexico School of Medicine, 900 Camino de Salud NE, Albuquerque, NM 87131
    Assistant Professor, Departments of Cell Biology and Pathology, and Director, UNM Center for Molecular and Cellular Diagnostics, University of New Mexico School of Medicine, Albuquerque, New Mexico.
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  • Barbara B. Griffith
    Staff Scientist and Technical Director, Molecular Diagnostics, UNM Center for Molecular and Cellular Diagnostics, University of New Mexico School of Medicine, Albuquerque, New Mexico.
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  • Michael Whittaker
    Fellow in Hematopathology, Department of Pathology, University of New Mexico School of Medicine, Albuquerque, New Mexico.
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      This paper is only available as a PDF. To read, Please Download here.
      The isolation of human DNA sequences that encode immunoglobulin genes, T cell receptor genes, and protooncogenes involved in the pathogenesis of lymphoid neoplasms has provided highly sensitive molecular probes to determine clonality and lineage in lymphopro-liferative lesions. The application of these probes to diagnostic problems in pathology has enhanced greatly the ability of the pathologist to determine clonality and lineage in lymphoid neoplasms, distinguish lymphoid from non-lymphoid tumors, monitor minimal residual disease, and identify early relapse.
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