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Research Article| Volume 10, ISSUE 1, P119-149, March 1990

Molecular Genetic Approaches for the Diagnosis of Clonality in Lymphoid Neoplasms

  • Cheryl L. Willman
    Correspondence
    Address reprint requests to: Cheryl L. Willman, MD, UNM Center for Molecular and Cellular Diagnostics, University of New Mexico School of Medicine, 900 Camino de Salud NE, Albuquerque, NM 87131
    Affiliations
    Assistant Professor, Departments of Cell Biology and Pathology, and Director, UNM Center for Molecular and Cellular Diagnostics, University of New Mexico School of Medicine, Albuquerque, New Mexico.
    Search for articles by this author
  • Barbara B. Griffith
    Affiliations
    Staff Scientist and Technical Director, Molecular Diagnostics, UNM Center for Molecular and Cellular Diagnostics, University of New Mexico School of Medicine, Albuquerque, New Mexico.
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  • Michael Whittaker
    Affiliations
    Fellow in Hematopathology, Department of Pathology, University of New Mexico School of Medicine, Albuquerque, New Mexico.
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DOI:https://doi.org/10.1016/S0272-2712(18)30585-7
Molecular Genetic Approaches for the Diagnosis of Clonality in Lymphoid Neoplasms
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      This paper is only available as a PDF. To read, Please Download here.
      The isolation of human DNA sequences that encode immunoglobulin genes, T cell receptor genes, and protooncogenes involved in the pathogenesis of lymphoid neoplasms has provided highly sensitive molecular probes to determine clonality and lineage in lymphopro-liferative lesions. The application of these probes to diagnostic problems in pathology has enhanced greatly the ability of the pathologist to determine clonality and lineage in lymphoid neoplasms, distinguish lymphoid from non-lymphoid tumors, monitor minimal residual disease, and identify early relapse.
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      Article info

      Footnotes

      The authors are supported in their work by National Institutes of Health Grants Kll DK01284 and CA32102 and State of New Mexico funds to the UNM Cancer Center. MW is a Clinical Oncology Fellow of the American Cancer Society.

      Identification

      DOI: https://doi.org/10.1016/S0272-2712(18)30585-7

      Copyright

      © 1990 Elsevier Inc. Published by Elsevier Inc. All rights reserved.

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