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Research Article| Volume 12, ISSUE 2, P277-304, June 1992

Chronic Granulomatous Disease: Diagnosis and Classification at the Molecular Level

DOI:https://doi.org/10.1016/S0272-2712(18)30516-X
Chronic Granulomatous Disease: Diagnosis and Classification at the Molecular Level
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      Chronic granulomatous disease (CGD) is caused by the failure of phagocytes to produce microbicidal derivatives of molecular oxygen, such as hydrogen peroxide. It is one of the best characterized of the phagocyte disorders and represents an important consideration in the differential diagnosis of recurrent infections. The clinical, biochemical, and molecular genetic aspects of CGD are reviewed in this context in this article.
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      DOI: https://doi.org/10.1016/S0272-2712(18)30516-X

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