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Research Article| Volume 12, ISSUE 2, P217-236, June 1992

Structural and Biologic Properties of Integrin-Mediated Cell Adhesion

  • David A. Cheresh
    Correspondence
    Address reprint requests to: David A. Cheresh, The Scripps Research Institute, 10666 N. Torrey Pines Road, La Jolla, CA 92037
    Affiliations
    From the Department of Immunology, The Scripps Research Institute, La folia, California
    Search for articles by this author
DOI:https://doi.org/10.1016/S0272-2712(18)30514-6
Structural and Biologic Properties of Integrin-Mediated Cell Adhesion
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      Integrins are a family of cell surface receptors that mediate cell-substrate and cell-cell interactions. They also potentiate an interaction with the cell cytoskeleton, promoting cell shape and migratory behavior. These events are crucial to normal cell development, differentiation, and migration. Integrins, however, also play a major role in conditions such as cancer, thrombosis, and inflammation. There-rore, in orcier to gam a basic understanding oi these biologic processes, it is imperative to investigate the structural, functional, and biologic properties of integrins.
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      DOI: https://doi.org/10.1016/S0272-2712(18)30514-6

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      © 1992 Elsevier Inc. Published by Elsevier Inc. All rights reserved.

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