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Research Article| Volume 12, ISSUE 3, P449-461, September 1992

Linkage Analysis and Predicting Genetic Disease

  • Joann A. Boughman
    Correspondence
    Address reprint requests to: Joann A. Boughman, PhD, Division of Human Genetics, University of Maryland at Baltimore, 405 W. Redwood Street, Suite 400, Baltimore, MD 21201
    Affiliations
    From the Division of Human Genetics, Departments of Obstetrics and Gynecology and Pediatrics, University of Maryland School of Medicine, Baltimore, Maryland.
    Search for articles by this author
  • Melissa J. Stick
    Affiliations
    From the Division of Human Genetics, Departments of Obstetrics and Gynecology and Pediatrics, University of Maryland School of Medicine, Baltimore, Maryland.
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  • Denise A. Peterson
    Affiliations
    From the Division of Human Genetics, Departments of Obstetrics and Gynecology and Pediatrics, University of Maryland School of Medicine, Baltimore, Maryland.
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  • Maimon M. Cohen
    Affiliations
    From the Division of Human Genetics, Departments of Obstetrics and Gynecology and Pediatrics, University of Maryland School of Medicine, Baltimore, Maryland.
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DOI:https://doi.org/10.1016/S0272-2712(18)30499-2
Linkage Analysis and Predicting Genetic Disease
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      This paper is only available as a PDF. To read, Please Download here.
      Linkage analysis is an important and clinically applicable method of predicting risk for genetic disorders and traits. When a gene cannot be detected directly, evaluation of a closely linked marker may be used in risk assessment. This review of linkage analysis provides basic information and examples of the application of these methods in genetic counseling situations.
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      Article info

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      DOI: https://doi.org/10.1016/S0272-2712(18)30499-2

      Copyright

      © 1992 Elsevier Inc. Published by Elsevier Inc. All rights reserved.

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