This paper is only available as a PDF. To read, Please Download here.
The most important clinical renal function to monitor with age is glomerular filtration rate (GFR), as all other changes in renal function tend to parallel changes in GFR. The serum creatinine and creatinine clearance have become the clinical tests most frequently used to measure GFR. The creatinine clearance decreases at a rate approximately 1% per year after age 40 years. Mean serum creatinine values, however, fail to increase with age because creatinine production, which is dependent on muscle mass, falls at nearly the same rate as the renal clearance of creatinine. Serum creatinine concentrations must be interpreted with this in mind when used to determine or modify dosages of drugs cleared totally, for example, the aminoglycoside antibiotics, or partially, for example, digoxin, by the kidney.
To read this article in full you will need to make a payment
Purchase one-time access:Academic & Personal: 24 hour online accessCorporate R&D Professionals: 24 hour online access
One-time access price info
- For academic or personal research use, select 'Academic and Personal'
- For corporate R&D use, select 'Corporate R&D Professionals'
Subscribers receive full online access to your subscription and archive of back issues up to and including 2002.
Content published before 2002 is available via pay-per-view purchase only.
Subscribe:Subscribe to Clinics in Laboratory Medicine
Already a print subscriber? Claim online access
Already an online subscriber? Sign in
Register: Create an account
Institutional Access: Sign in to ScienceDirect
- Effect of acute acid loading on urinary acid excretion by the aging human kidney.J Lab Clin Med. 1968; 72: 278-289
- Renal acidification in elderly subjects.Nephron. 1980; 26: 291-293
- Prediction of creatinine clearance from serum creatinine.Nephron. 1976; 16: 31-41
- Age changes in glomerular filtration rate, effective renal plasma flow, and tubular excretory capacity in adult males.J Clin Invest. 1950; 29: 496-507
- Glomerular permeability in young and old subjects.J Gerontol. 1962; 17: 40-44
- Clinical assessment of glomerular filtration rate and a modified phenosul-phonphthalein test.Am J Med. 1968; 44: 343-358
- Senescence and the renal vasculature in normal man.Circ Res. 1974; 34: 309-316
- Influence of age, renal disease, hypertension, diuretics and calcium on the antidiuretic response to suboptimal infusions of vasopressin.J Lab Clin Med. 1966; 68: 206-224
- Longitudinal studies on the rate of decline in renal function with age.J Am Geriatr Soc. 1985; 33: 278-285
- Osmolar renal concentrating ability in healthy young men and hospitalized patients without renal disease.N Engl J Med. 1960; 262: 1306-1309
- The glomerular clearance and renal transport of hemoglobin in adult males.J Clin Invest. 1961; 40: 1172-1177
- Aging as a factor in the renal hemodynamic changes induced by a standardized pyrogen.J Clin Invest. 1951; 5: 457-462
- The renal extraction of p-aminohippurate in the aged individual.J Gerontol. 1951; 6: 213-216
- Age changes in the maximal rate of renal tubular reabsorption of glucose.J Gerontol. 1952; 7: 196-200
- Age differences in the renal tubular response to antidiuretic hormone.J Gerontol. 1953; 8: 446-450
- The effect of age on creatinine clearance in men: A cross sectional and longitudinal study.J Gerontol. 1976; 31: 155-163
- Human aging: usual and successful.Science. 1987; 237: 143-149
- The influence of age on the renal response to water deprivation in man.Nephron. 1976; 17: 270-278
- Age changes in the acid-base equilibrium of the blood in males.J Gerontol. 1950; 5: 1-4
- Some data on the genito-urinary system as found in old-age surveys in the Netherlands.Gerontol Clin. 1959; 1: 167-173
- Renal hemodynamics in physiological states.in: Wesson Jr, L.G. Physiology of the Human Kidney. Grune and Stratton, New York1969: 98-100
© 1993 Elsevier Inc. Published by Elsevier Inc. All rights reserved.