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The tests most commonly used to estimate the status of renal function via alterations
in glomerular filtration rate (GFR) are plasma creatinine concentration (PCr), blood,
urea, nitrogen (BUN), and creatinine clearance (CCr). Unfortunately, these tests have
some drawbacks. Nevertheless, they are quite useful to clinicians aware of their limitations,
especially in many instances when it may be unnecessary or impractical to have precise
measurements. Accordingly, serial measurements of PCr, especially when related to
simultaneous BUN determinations, or CCr, may suffice. However, the functional status
of the kidneys often needs to be corroborated by more precise methods when subtle
changes in renal function are detected or when clinically indicated.
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© 1993 Elsevier Inc. Published by Elsevier Inc. All rights reserved.