Research Article| Volume 13, ISSUE 3, P583-598, September 1993

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Thyroid Hormone Transport Proteins

  • Luigi Bartalena
    Address reprint requests to Luigi Bartalena, MD Istituto di Endocrinologia University of Pisa Viale del Tirreno, 64 56018 Tirrenia-Pisa, Italy.
    From the Istituto di Endocrinologia, University of Pisa, Pisa, Italy
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  • Jacob Robbins
    Endocrinology Section, Genetics and Biochemistry Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland
    Search for articles by this author
      This paper is only available as a PDF. To read, Please Download here.
      Thyroxine-binding globulin, transthyretin, and albumin are the major thyroid hormone-binding proteins in human serum. Inherited and acquired variations in serum concentration or affinity of these proteins are described. These changes produce substantial variations in the total serum concentration of thyroid hormones, but do not affect the metabolically active thyroid status. Recognition of thyroid hormone binding protein abnormalities is crucial to avoid inappropriate and detrimental treatments for hyperthyroidism or hypothyroidism.
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