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Research Article| Volume 13, ISSUE 3, P563-581, September 1993

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Resistance to Thyroid Hormone

  • Samuel Refetoff
    Correspondence
    Address reprint requests to Samuel Refetoff, MD University of Chicago 5481 South Maryland Avenue Box 11138 Chicago, IL 60637.
    Affiliations
    From the Departments of Medicine and Pediatrics, The University of Chicago, Chicago, Illinois
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DOI:https://doi.org/10.1016/S0272-2712(18)30426-8
Resistance to Thyroid Hormone
Previous ArticleMolecular Mechanisms of Thyroid Hormone Action: A Physiologic Perspective
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      Resistance to thyroid hormone encompasses a clinically heterogeneous group of conditions characterized by reduced responses of target tissues to a supply of thyroid hormone that under normal circumstances would be excessive. The syndrome of resistance to thyroid hormone is first suspected when serum thyroid hormone levels are found to be elevated in the presence of nonsuppressed serum thyrotropin (TSH). Clinical confirmation of the diagnosis requires the demonstration of the failure of full replacement doses of thyroid hormone to produce the expected suppressive effect on the secretion of TSH and a failure to induce appropriate responses in peripheral tissues.
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      Article info

      Footnotes

      Supported in part by United States National Institutes of Health (grant DK 15,070) and Public Health Service (grant RR 00,055).

      Portions of this text have been excerpted from Refetoff S: Clinical and genetic aspects of resistance to thyroid hormone. The Endocrinologist 2:261-271, 1992; with permission.

      Identification

      DOI: https://doi.org/10.1016/S0272-2712(18)30426-8

      Copyright

      © 1993 Elsevier Inc. Published by Elsevier Inc. All rights reserved.

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