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Research Article| Volume 13, ISSUE 3, P531-541, September 1993

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Molecular Mechanisms of Thyroid Hormone Action

  • Allan R. Shepard
    Correspondence
    Address reprint requests to Norman L. Eberhardt, PhD 4-407 Alfred Mayo Clinic Rochester, MN 55905.
    Affiliations
    From the Department of Biochemistry and Molecular Biology and the Division of Endocrinology, Metabolism and Internal Medicine, Mayo Clinic and Mayo Foundation, Rochester, Minnesota
    Search for articles by this author
  • Norman L. Eberhardt
    Affiliations
    From the Department of Biochemistry and Molecular Biology and the Division of Endocrinology, Metabolism and Internal Medicine, Mayo Clinic and Mayo Foundation, Rochester, Minnesota
    Search for articles by this author
DOI:https://doi.org/10.1016/S0272-2712(18)30424-4
Molecular Mechanisms of Thyroid Hormone Action
Previous ArticlePreface
Next ArticleMolecular Mechanisms of Thyroid Hormone Action: A Physiologic Perspective
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      This review summarizes our current understanding of the mechanisms of thyroid hormone action. Topics included are the structures of thyroid hormone response elements (TREs), thyroid hormone receptor (TR)-TRE interactions, and TR association with other proteins to illustrate their importance in modulating both positive and negative transcriptional activation of specific genes. Certain studies focusing on other members of the steroid/thyroid hormone receptor superfamily are covered to provide a current view of how this class of receptors stabilizes transcription initiation complexes.
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      Article info

      Footnotes

      This work was supported by Grant No. DK41206 for the National Institutes of Health.

      Identification

      DOI: https://doi.org/10.1016/S0272-2712(18)30424-4

      Copyright

      © 1993 Elsevier Inc. Published by Elsevier Inc. All rights reserved.

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