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Research Article| Volume 14, ISSUE 2, P271-299, June 1994

The Cytotoxic T-Lymphocyte Response in HIV-1 Infection

  • Spyros A. Kalams
    Correspondence
    Address reprint requests to Spyros A. Kalams, MD, Infectious Disease Unit, Massachusetts General Hospital East, 149 13th Street, 5th Floor, Charlestown, MA 02129.
    Affiliations
    From the Massachusetts General Hospital Infectious Disease Unit, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts
    Search for articles by this author
  • Bruce D. Walker
    Affiliations
    From the Massachusetts General Hospital Infectious Disease Unit, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts
    Search for articles by this author
DOI:https://doi.org/10.1016/S0272-2712(18)30379-2
The Cytotoxic T-Lymphocyte Response in HIV-1 Infection
Previous ArticleHIV-1 Antibodies and Serology
Next ArticleHIV-1 Burden as a Marker of Disease Progression and Clinical Response to Therapy in AIDS
      This paper is only available as a PDF. To read, Please Download here.
      HIV infection is associated with an extremely vigorous virus-specific cytotoxic T-lymphocyte (CTL) response. This CTL activity is of sufficient magnitude to be detected using freshly isolated peripheral blood mononuclear cells, but despite this vigorous immune response, HIV-1 disease ultimately progresses. This article describes methods used to detect CTL responses and epitopes recognized by HIV-1 specific CTL. The potential role of CTL in the control of viral replication, disease pathogenesis, and possible mechanisms that allow HIV-1 to ultimately evade the host’s immune response is discussed. Finally, efforts to induce CTL responses through vaccines are summarized.
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      DOI: https://doi.org/10.1016/S0272-2712(18)30379-2

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      © 1994 Elsevier Inc. Published by Elsevier Inc. All rights reserved.

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