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Research Article| Volume 14, ISSUE 2, P221-238, June 1994

HIV-Induced T-Lymphocyte Depletion

  • Elaine Schattner
    Correspondence
    Address reprint requests to Elaine Schattner, MD, Division of Hematology-Oncology Room C-606, The New York Hospital-Cornell Medical Center, 525 East 68th Street, New York, NY 10021.
    Affiliations
    From the Laboratory for AIDS Virus Research, Division of Hematology-Oncology, Department of Medicine, The New York Hospital-Cornell Medical Center, New York, New York
    Search for articles by this author
  • Jeffrey Laurence
    Affiliations
    From the Laboratory for AIDS Virus Research, Division of Hematology-Oncology, Department of Medicine, The New York Hospital-Cornell Medical Center, New York, New York
    Search for articles by this author
DOI:https://doi.org/10.1016/S0272-2712(18)30376-7
HIV-Induced T-Lymphocyte Depletion
Previous ArticleMolecular Biology of HIV
Next ArticleCellular Latency in HIV-1 Infection
      This paper is only available as a PDF. To read, Please Download here.
      A fundamental paradox of HIV disease is the progressive diminution in CD4+ lymphocytes despite the fact that only a small fraction of cells are infected. The mechanisms of T-cell depletion in HIV disease are divers. These include immune and autoimmune destruction of infected and uninfected cells, signaling derangements inducing clonal anergy and apoptosis, and direct cytotoxic effects of viral particles. These phenomena are reviewed as they pertain to the different clinical stages of HIV infection.
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      Footnotes

      Work for this article was supported by grants from the National Institutes of Health (AI33322), the US Army Medical Research and Acquisitions Division (DAMD17-90-Z-0049), and the Pediatric AIDS Foundation.

      Identification

      DOI: https://doi.org/10.1016/S0272-2712(18)30376-7

      Copyright

      © 1994 Elsevier Inc. Published by Elsevier Inc. All rights reserved.

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