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Research Article| Volume 15, ISSUE 3, P685-704, September 1995

Pathobiology of Human Papillomavirus

  • Chaya J. Prasad
    Correspondence
    Address reprint requests to Chaya J. Prasad, MD Oregon Regional Primate Research Center 505 NW 185th Avenue Portland, OR 97006
    Affiliations
    From the Department of Pathology, Oregon Health Sciences University, and Oregon Regional Primate Research Center, Portland, Oregon
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DOI:https://doi.org/10.1016/S0272-2712(18)30324-X
Pathobiology of Human Papillomavirus
Previous ArticleUpdate on Laboratory Diagnosis of Sexually Transmitted Diseases
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      This paper is only available as a PDF. To read, Please Download here.
      Human papillomavirus (HPV) has long been recognized as the etiologic agent of skin and genital warts, and only recently has an oncogenic role been attributed to the virus. This article discusses the classification, genetics, and pathogenesis of HPV. HPV detection, epidemiology of HPV and cervical neoplasia, and HPV infections in the genital tract are also reviewed.
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      References

        • Agoff S.N.
        • Hou J.
        • Linzer SIH
        • et al.
        Regulation of the human hsp70 promotor by p53.
        Science. 1993; 259: 84-87
        • Arends M.J.
        • Donaldson Y.K.
        • Duvall E.
        • et al.
        Human papillomavirus type 18 associates with more advanced cervical neoplasia than human papillomavirus type 16.
        Hum Pathol. 1993; 24: 432-437
        • Ayer J.E.
        The vaginal smear, “precancer” cell using a modified technique.
        Am J Obstet Gynecol. 1959; 58: 1205-1209
        • Ayer J.E.
        Role of the halo cell in cervical carcinogenesis.
        Obstet Gynecol. 1960; 15: 481-491
        • Bauer H.M.
        • Hildesheim A.
        • Schiffman M.H.
        • et al.
        Determinants of genital human papillomavirus infection in low-risk women in Portland, Oregon.
        Sex Trans Dis. 1993; 20: 274-278
        • Bergerson C.
        • Barrasso R.
        • Beaudenon S.
        Human papillomaviruses associated with cervical intraepithelial neoplasia. Great diversity and distinct distribution in low-grade and high-grade lesions.
        Am J Surg Pathol. 1992; 16: 641-649
        • Beutner K.R.
        Human papillomavirus infection. Periodic synopsis.
        J Am Acad Dermatol. 1989; 90: 114-123
        • Broker T.R.
        Structure and genetic expression of papillomaviruses.
        Obstet Gynecol Clin North Am. 1987; 14: 329-343
        • Burghardt E.
        Early histologic diagnosis of cervical cancer. George Thieme Verlag, Stuttgart1973
        • Choo K.B.
        • Pan C.C.
        • Han S.H.
        Integration of human papillomavirus type 16 into cellular DNA of cervical carcinoma: preferential deletion of the E2 gene and invariable retention of the long control region and the E6/E7 open reading frames.
        Virology. 1987; 161: 259-261
        • Crook T.
        • Fisher C.
        • Masterson P.J.
        • et al.
        Modulation of transcriptional regulatory properties of p53 by HPV E6.
        Oncogene. 1994; 9: 1225-1230
        • Crum C.P.
        • Nuovo G.J.
        Genital Papillomavirus and Related Neoplasms. Raven Press, New York1991
        • Cullen A.
        • Reid R.
        • Campion M.
        • et al.
        Analysis of the physical state of different human papillomavirus DNAs in intraepithelial and invasive cervical neoplasms.
        J Virol. 1991; 65: 606-612
        • De Villiers E.M.
        Heterogeneity of the human papillomavirus group.
        J Virol. 1989; 63: 4898-4903
        • De Villiers E.M.
        • Gissman L.
        • Zur Hausen H.
        Molecular cloning of viral DNA from human genital warts.
        J Virol. 1981; 40: 932-935
        • Durst M.
        • Kleinheinz H.
        • Hotz M.
        • et al.
        The physical state of human papillomavirus type 16 DNA in benign and malignant genital tumors.
        J Gen Virol. 1985; 66: 1515-1522
        • Dyson N.
        • Howley P.M.
        • Munger K.
        • et al.
        The human papillomavirus 16 E7 oncoprotein is able to bind to the retinoblastoma gene product.
        Science. 1989; 243: 934-937
        • Ferenczy A.
        • Braun L.
        • Shah K.V.
        Human papillomavirus in condylomatous lesions of the cervix: A comparative ultrastructural and immunohistochemical study.
        Am J Surg Pathol. 1981; 5: 661-670
      19. Epidemiology of Cervical Cancer and Human Papillomavirus. IARC Scientific Publications, Lyon1992
        • Franco E.L.
        The sexually transmitted disease model for cervical cancer: Incoherent epidemiologic findings and the role of misclassification of human papillomavirus infection.
        Epidemiology. 1991; 2: 98-106
        • Genest D.R.
        • Stein L.
        • Cibas E.
        • et al.
        A binary (Bethesda) system for classifying cervical cancer precursors: Criteria, reproducibility and viral correlates.
        Hum Pathol. 1993; 24: 730-736
        • Gu Z.
        • Pirn D.
        • Labrecque S.
        • et al.
        DNA damage induced p53 mediated transcription is inhibited by human papillomavirus type 18 E6.
        Oncogene. 1994; 9: 629-633
        • Gutman L.T.
        • Herman-Giddens M.E.
        • Phelps W.C.
        Transmission of human papillomavirus disease: Comparison of data from adults and children.
        Pediatrics. 1993; 91: 31-38
        • Hawley-Nelson P.
        • Vousden K.H.
        • Hubbert N.L.
        • et al.
        HPV 16 E6 and E7 proteins cooperate to immortalize human foreskin keratinocytes.
        EMBO. 1989; 8: 3905-3910
        • Hildesheim A.
        • Gravitt P.
        • Schiffman M.H.
        • et al.
        Determinants of genital human papillomavirus infection in low income women in Washington D.C.
        Sex Trans Dis. 1993; 20: 279-285
        • Jerwers R.J.
        • Hildebrandt P.
        • Ludlow J.W.
        • et al.
        Regions of human papillomavirus type 16 E7 oncoprotein required for immortalization of human keratinocytes.
        J Virol. 1992; 66: 1329-1335
        • Kiviat N.B.
        • Critchlow C.W.
        • Kurman R.J.
        Reassessment of the morphologic continuum of cervical intraepithelial lesions; does it reflect different stages in the progression of cervical carcinoma?.
        in: Munoz N. Bosch F. Shah K. The Epidemiology of Cervical Cancer and Human Papillomavirus. IARC, Lyons1992: 59-66
        • Koss L.G.
        Diagnostic Cytology and Histopathologic Basis. JB Lippincott, New York1992
        • Koss L.G.
        • Durfee D.R.
        Unusual patterns of squamous epithelium of the uterine cervix: Cytologic and pathologic study of koilocytotic atypia.
        Ann N Y Acad Sci. 1956; 63: 1245-1261
        • Koutsy L.A.
        • Holmes K.K.
        • Critchlow C.W.
        A cohort study of the risk of cervical intraepithelial neoplasia grade 2 or 3 in relation to human papillomavirus infection.
        N Engl J Med. 1992; 327: 1272-1278
      31. Kurman R.J. Blaustein’s Pathology of the Female Genital Tract. ed 4. Springer-Verlag, New York1994
        • Kurman R.J.
        • Toki T.
        • Schiffman M.H.
        Basaloid and warty carcinoma of the vulva.
        Am J Surg Pathol. 1993; 17: 133-145
        • Larsen N.S.
        Invasive cervical cancer rising in young white females.
        J Natl Cancer Inst. 1994; 86: 6-7
        • Ley S.
        • Bauer H.M.
        • Reingold A.
        • et al.
        Determinants of genital human papillomavirus infection in young women.
        J Natl Cancer Inst. 1991; 83: 997-1003
        • Lorincz A.T.
        Detection of human papillomavirus infection by nucleic acid hybridization.
        Obstet Gynecol Clin North Am. 1987; 14: 451-469
        • Lorincz A.T.
        • Reid R.
        • Jensen A.B.
        Human papillomavirus infection of the cervix: Relative risk associations of 15 common anogenital types.
        Am J Obstet Gynecol. 1992; 79: 328-337
        • Lorincz A.T.
        • Temple G.F.
        • Kurman R.J.
        Oncogenic associations of specific human papillomavirus types with cervical neoplasia.
        J Natl Cancer Inst. 1987; 79: 671-677
        • Lungu O.
        • Sun X.W.
        • Felix J.
        Relationship of human papillomavirus type to grade of cervical intraepithelial neoplasia.
        JAMA. 1992; 267: 2493-2496
        • Lungu O.
        • Wright T.C.
        • Silverstein S.
        Typing of human papillomaviruses by polymerase chain reaction amplification with LI consensus primers and RFLP analysis.
        Mol Cell Probes. 1992; 6: 145-152
        • Matsukura T.
        • Koi S.
        • Sugase M.
        Both episomal and integrated forms of human papillomavirus type 16 are involved in cervical cancers.
        Virology. 1989; 172: 63-72
        • Meisels A.
        • Fortin R.
        Condylomatous lesions of the cervix and vagina. 1 Cytologic patterns.
        Acta Cytol. 1976; 20: 505-509
        • Melczar H.
        Uber die atiologische identitat der gewohnlichen Warzen und Spitzen Kondylome.
        Hautarzt. 1965; 16: 150-153
        • Mitchell M.
        • Prasad C.
        • Silva P.E.
        • et al.
        Second primary squamous neoplasms in patients with vulvar carcinoma: Viral (HPV) and histologic correlates.
        Obstet Gynecol. 1993; 81: 13-18
        • Munger K.
        • Phelps W.C.
        • Bubb V.
        • et al.
        The E6 and E7 genes of human papillomavirus type 16 are necessary and sufficient for transformation of primary human keratinocytes.
        J Virol. 1989; 63: 4417-4421
        • Munoz N.
        • Bosch X.
        • Kaldor G.M.
        Does human papillomavirus cause cervical cancer: The state of the epidemiologic evidence.
        Br J Cancer. 1988; 57: 1-5
        • Nasiell K.
        • Nasiell M.
        Cervical dysplasia during long term follow-up.
        Obstet Gynecol. 1994; 67: 665-669
        • Nasiell K.
        • Nasiell M.
        • Auer G.
        Behaviour of moderate cervical dysplasia during long term follow-up.
        Obstet Gynecol. 1983; 61: 609-614
        • National Cancer Institute Workshop
        The 1988 Bethesda System for reporting cervical/vaginal cytologic diagnoses.
        JAMA. 1989; 262: 931-934
        • National Cancer Institute Workshop
        The revised Bethesda System for reporting cervical/vaginal cytologic diagnoses.
        JAMA. 1991; 267: 1892
        • Nuovo G.J.
        In Situ Hybridization: Protocols and Applications. Raven Press, New York1992
        • Nuovo G.J.
        Detection of human papillomavirus DNA in the lower genital tract.
        Infect Urol. 1994; 7: 87-93
        • Nuovo G.J.
        • Babury R.
        • Calayag P.
        Human papillomavirus types and recurrent cervical warts in immunocompromised women.
        Mod Pathol. 1991; 4: 632-636
        • Nuovo G.J.
        • Richart R.
        A comparison of slot blot, Southern blot and in-situ hybridization analyses for human papillomavirus DNA in genital tract lesions.
        Obstet Gynecol. 1989; 74: 673-677
        • Nuovo G.J.
        • Silverstein S.J.
        Comparison of formalin, buffered formalin, and Bouin’s fixative on the detection of human papillomavirus DNA from genital lesions.
        Lab Invest. 1988; 59: 720-724
        • Park J.S.
        • Jones J.L.
        • McLean M.R.
        • et al.
        Possible eitiologic heterogeneity of vulvar intraepithelial neoplasia: A correlation of pathologic characteristics with HPV detection by in situ hybridization and PCR.
        Cancer. 1991; 67: 1599-1607
        • Peng T.C.
        • Searle C.P.
        • Shah K.V.
        • et al.
        Prevalence of human papillomavirus infections in term pregnancy.
        Am J Perinatol. 1990; 7: 189-192
        • Prasad C.J.
        • Genest D.R.
        • Crum C.P.
        Atypical squamous epithelium of undetermined significance.
        Int J Gynecol Pathol. 1994; 13: 220-227
        • Prasad C.J.
        • Sheets E.
        • Selig A.M.
        • et al.
        The binucleate squamous cell: histologic spectrum and relationship to low-grade squamous intraepithelial lesions.
        Mod Pathol. 1993; 6: 313-317
        • Purola E.
        • Savia E.
        Cytology of gynecologic condyloma acuminatum.
        Acta Cytol. 1977; 21: 26-31
        • Reid R.
        • Greenberg M.
        • Jense A.B.
        Sexually transmitted papillomaviral infections 1. The anatomic distribution and pathologic grade of neoplastic lesions associated with different viral types.
        Am J Obstet Gynecol. 1987; 156: 212-222
        • Roman A.
        • Fife K.H.
        Human papillomaviruses. Are we ready to type?.
        Clin Microbiol Rev. 1989; 2: 166-190
        • Rous P.
        • Kidd J.G.
        The carcinogenic effect of a virus upon tarred skin.
        Science. 1936; 83: 468-469
        • Schwarz E.
        • Freese J.K.
        • Gissman L.
        • et al.
        Structure and transcription of human papillomavirus sequences in cervical carcinoma cells.
        Nature. 1985; 314: 111-114
        • Scheffner M.
        • Munger K.
        • Byrne J.C.
        • et al.
        The state of the p53 and retinoblastoma genes in human cervical carcinoma cell lines.
        Proc Natl Acad Sci. 1991; 88: 5523-5527
        • Scheffner M.
        • Romanczuk H.
        • Munger K.
        • et al.
        Functions of human papillomavirus proteins.
        Curr Topics Microbiol Immunol. 1994; 186: 83-99
        • Scheffner M.
        • Wemess B.A.
        • Huibregtse J.M.
        • et al.
        The E6 oncoprotein encoded by human papillomaviruses types 16 and 18 promotes the degradation of p53.
        Cell. 1990; 63: 1129-1136
        • Schiffman M.H.
        Recent progress in defining the epidemiology of human papillomavirus infection and cervical neoplasia.
        J Natl Cancer Inst. 1992; 84: 394-398
        • Schiffman M.H.
        Epidemiology of cervical human papillomavirus infections.
        Curr Topics Microbiol Immunol. 1994; 186: 55-81
        • Schiffman M.H.
        • Bauer H.M.
        • Hoover R.N.
        • et al.
        Epidemiologic evidence showing that human papillomavirus infection causes most cervical intraepithelial neoplasia.
        J Natl Cancer Inst. 1993; 85: 958-964
        • Seto E.
        • Usheva A.
        • Zambetti G.P.
        • et al.
        Wild type p53 binds to the TATA-binding protein and represses transcription.
        Proc Natl Acad Sci. 1992; 89: 12028-12032

      71. Sherman ME, Schiffman MH, Lorincz AT, et al: Towards objective quality assurance in cervical cytopathology: Correlation of cytopathologic diagnoses with detection of high-risk HPV types. Am J Clin Pathol (in press)

        • Stoler M.H.
        • Mills S.E.
        • Gersell D.J.
        Small-cell neuroendocrine carcinoma of the cervix: A human papillomavirus type 18 associated cancer.
        Am J Surg Pathol. 1991; 15: 28-32
        • Strauss M.J.
        • Shaw E.W.
        • Bunting H.
        “Crystalline” virus-like particles from skin papillomas characterized by intranuclear inclusion bodies.
        Proc Soc Exp Biol Med. 1949; 72: 46-50
        • Toki T.
        • Kurman R.J.
        • Park J.S.
        • et al.
        Probable nonpapillomavirus eitiology of squamous cell carcinoma of the vulva in older women: A clinicopathologic study using in situ hybridization and polymerase chain reaction.
        Int J Gynecol Pathol. 1991; 10: 107-125
        • Vousden K.
        Interactions of human papillomavirus transforming proteins with the products of tumor suppressor genes.
        FASEB J. 1993; 7: 872-879
        • Watanabe S.
        • Kanda T.
        • Yoshike K.
        Human Papillomavirus type 16 transformation of primary human embryonic fibroblasts requires expression of open reading frames E6 and E7.
        J Virol. 1989; 63: 965-969
        • Werness B.A.
        • Levine A.J.
        • Howley P.M.
        Association of human papillomavirus types 16 and 18 E6 proteins with p53.
        Science. 1990; 248: 76-79
        • Willet G.D.
        • Kurman R.J.
        • Reid R.
        Correlation of the histologic appearance of intraepithelial neoplasia of the cervix with human papillomavirus types.
        Int J Gynecol Pathol. 1989; 8: 18-25
        • Zur Hausen H.
        Condylomata and human genital cancer.
        Cancer Res. 1976; 36: 530
        • Zur Hausen H.
        Papillomaviruses in anogenital cancer as a model to understand the role of viruses in human cancers.
        Cancer Res. 1989; 49: 4677-4681
        • Zur Hausen H.
        Molecular pathogenesis of cancer of the cervix and its causation by specific human papillomavirus types.
        Curr Topics Microbiol Immunol. 1994; 186: 132-156

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      DOI: https://doi.org/10.1016/S0272-2712(18)30324-X

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      © 1995 Elsevier Inc. Published by Elsevier Inc. All rights reserved.

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