Advertisement
Research Article| Volume 15, ISSUE 3, P611-629, September 1995

Selected Vascular Lesions of the Placenta

  • Deborah J. Gersell
    Correspondence
    Address reprint requests to Deborah J. Gersell, MD Department of Pathology Washington University School of Medicine One Barnes Hospital Plaza St. Louis, MO 63110
    Affiliations
    From the Department of Pathology, Washington University School of Medicine, St. Louis, Missouri
    Search for articles by this author
DOI:https://doi.org/10.1016/S0272-2712(18)30321-4
Selected Vascular Lesions of the Placenta
Previous ArticleNew Developments in Sex Cord-Stromal and Germ Cell Tumors of the Ovary
Next ArticleGestational Trophoblastic Disease: New Approaches to Diagnosis
      This paper is only available as a PDF. To read, Please Download here.
      The double circulation of the placenta results in great diversity in the morphologic expression of vascular lesions. Although the etiology and pathogenesis of many of these lesions are not completely understood, it is clear that some have potentially serious implications for fetal well-being. This article focuses on the diagnostic criteria and clinical significance of selected placental vascular lesions.
      To read this article in full you will need to make a payment

      Purchase one-time access:

      Academic & Personal: 24 hour online accessCorporate R&D Professionals: 24 hour online access
      One-time access price info
      • For academic or personal research use, select 'Academic and Personal'
      • For corporate R&D use, select 'Corporate R&D Professionals'

      Subscribers receive full online access to your subscription and archive of back issues up to and including 2002.

      Content published before 2002 is available via pay-per-view purchase only.

      Subscribe:

      Subscribe to Clinics in Laboratory Medicine
      Already a print subscriber? Claim online access
      Already an online subscriber? Sign in
      Register: Create an account
      Institutional Access: Sign in to ScienceDirect

      References

        • Abitbol M.M.
        • Driscoll S.G.
        • Ober W.B.
        Placental lesions in experimental toxemia in the rabbit.
        Am J Obstet Gynecol. 1976; 125: 942-948
        • Abitol M.M.
        • Pirani C.L.
        • Ober W.B.
        • et al.
        Production of experimental toxemia in the pregnant dog.
        Obstet Gynecol. 1976; 48: 537-548
        • Abramowsky C.R.
        • Veges M.E.
        • Swinehert G.
        • et al.
        Decidual vasculopathy of the placenta in lupus erythematosus.
        N Engl J Med. 1980; 303: 668-672
        • Althabe O.
        • Labarrere C.
        • Telenta M.
        Maternal vascular lesions in placentae of small-for-gestational age infants.
        Placenta. 1985; 6: 265-276
        • Altshuler G.
        Chorangiosis. An important placental sign of neonatal morbidity and mortality.
        Arch Pathol Lab Med. 1984; 108: 71-74
        • Altshuler G.
        The placenta.
        in: Sternberg S.S. Mills S.E. Surgical Pathology of the Female Reproductive System and Peritoneum. Raven Press, New York1991: 31
        • Andres R.L.
        • Kuyper W.
        • Resnik R.
        • et al.
        The association of maternal floor infarction of the placenta with adverse perinatal outcome.
        Am J Obstet Gynecol. 1990; 163: 935-938
        • Benirschke K.
        • Kaufman P.
        Pathology of the Human Placenta. ed 2. Springer-Verlag, New York1990
        • Bloomfield R.D.
        • Suarez J.R.
        • Malangit A.C.
        The placenta: A diagnostic tool in sickle cell disorders.
        J Natl Med Assoc. 1978; 70: 87-88
        • Branch D.W.
        • Andres R.
        • Digre K.B.
        • et al.
        The association of antiphospholipid antibodies with severe preeclampsia.
        Obstet Gyncol. 1989; 73: 541-545
        • Brosens I.
        • Dixon H.G.
        • Robertson W.B.
        Fetal growth retardation and the arteries of the placental bed.
        Br J Obstet Gynaecol. 1977; 84: 656-663
        • Browne J.C.
        The uterine circulation in toxemia.
        Clin Obstet Gynecol. 1958; 1: 341-348
        • Browne J.C.
        • Veall N.
        The maternal placental blood flow in normotensive and hypertensive women.
        J Obstet Gynaecol Br Emp. 1953; 60: 141-147
        • Carreras L.O.
        • Vermylen J.
        ‘Tupus” anticoagulant and inhibition of prostacyclin formation in patients with repeated abortion, intrauterine growth retardation and intrauterine death.
        Br J Obstet Gynaecol. 1981; 88: 890-894
        • Clewell W.H.
        • Manchester D.K.
        Recurrent maternal floor infarction: A preventable cause of fetal death.
        Am J Obstet Gynecol. 1983; 147: 346-347
        • Devi B.
        • Jennison R.F.
        • Langley F.A.
        Significance of placental pathology in transplacental haemorrhage.
        J Clin Pathol. 1968; 21: 322-331
        • Dewolf F.
        • Robertson W.B.
        • Brosens I.
        The ultrastructure of acute atherosis in hypertensive pregnancy.
        Am J Obstet Gynecol. 1975; 123: 164-174
        • DeWolf F.
        • Brosens I.
        • Renaer M.
        Fetal growth retardation and the maternal arterial supply of the human placenta in the absence of sustained hypertension.
        Br J Obstet Gynaecol. 1980; 87: 678-685
        • DeWolf F.
        • DeWolf-Peters C.
        • Brosens I.
        • et al.
        The human placental bed: Electron microscopic study of trophoblastic invasion of spiral arteries.
        Am J Obstet Gynecol. 1980; 137: 58-70
        • DeWolf F.
        • Carreras L.O.
        • Moerman P.
        • et al.
        Decidual vasculopathy and extensive placental infarction in a patient with repeated thromboembolic accidents, recurrent fetal loss, and a lupus anticoagulant.
        Am J Obstet Gynecol. 1982; 142: 829-834
        • Driscoll S.G.
        The pathology of pregnancy complicated by diabetes mellitus.
        Med Clin North Am. 1965; 49: 1053-1067
        • Feinstein D.I.
        Lupus antocoagulant, thrombosis, and fetal loss.
        N Engl Med. 1985; 313: 1348-1350
        • Feinstein D.I.
        Lupus anticoagulant, anticardiolipin antibodies, fetal loss, and systemic lupus erythematosus.
        Blood. 1992; 80: 859-862
        • Fox H.
        Abnormalities of the foetal stem arteries in the human placenta.
        J Obstet Gynaecol Br Commonw. 1967; 74: 734-738
        • Fox H.
        Morphological changes in human placenta following fetal death.
        J Obstet Gynaecol Br Commonw. 1968; 75: 839-843
        • Fox H.
        Effect of hypoxia on trophoblast in organ culture. A morphologic and autoradiographic study.
        Am J Obstet Gynecol. 1970; 107: 1058-1064
        • Fox H.
        Pathology of the placenta.
        in: Bennington J.L. Major Problems in Pathology, vol 7. WB Saunders, Philadelphia1978
        • Fujikura T.
        • Benson R.
        Placentitis and fibrous occlusion of fetal vessels in the placentas of stillborn infants.
        Am J Obstet Gynecol. 1964; 89: 225-229
        • Fujikura T.
        • Froehlich L.
        Diagnosis of sickling by placental examination. Geographic differences in incidence.
        Am J Obstet Gynecol. 1968; 100: 1122-1124
        • Genest D.R.
        • Williams M.A.
        • Green M.F.
        Estimating the time of death in stillborn fetuses: II Histologic evaluation of the placenta: A study of 71 stillborns.
        Obstet Gynecol. 1992; 80: 585-592
        • Ginsberg J.S.
        • Brill-Edwards P.
        • Johnston M.
        • et al.
        Relationship of antiphospholipid antibodies to pregnancy loss in patients with systemic lupus erythematosus: A cross-sectional study.
        Blood. 1992; 80: 975-980
        • Gruenwald P.
        Abnormalities of placental vascularity in relation to intrauterine deprivation and retardation of fetal growth: Significance of avascular chorionic villi.
        N Y State J Med. 1961; 61: 1508-1513
        • Infante-Rivard C.
        • David M.
        • Bauthier R.
        • et al.
        Lupus anticoagulants, anticardiolipin antibodies, and fetal loss: A case-control study.
        N Engl J Med. 1991; 325: 1063-1066
        • Jones CJP
        • Fox H.
        An ultrastructural and ultrahistochemical study of the human placenta in maternal essential hypertension.
        Placenta. 1981; 2: 193-204
        • Kaplan C.
        • Blanc W.A.
        • Elias J.
        Identification of erythrocytes in intervillous thrombi. A study using immunoperoxidase identification of hemoglobins.
        Hum Pathol. 1982; 13: 554-557
        • Khong T.Y.
        • Pearce J.M.
        • Robertson W.B.
        Acute atherosis in preeclampsia: Maternal determinants and fetal outcome in the presence of the lesion.
        Am J Obstet Gynecol. 1987; 157: 360-362
        • Khong T.Y.
        Acute atherosis in pregnancies complicated by hypertension, small-for-gestational-age infants, and diabetes mellitus.
        Arch Pathol Lab Med. 1991; 115: 722-725
        • Kitzmiller J.L.
        • Watt N.
        • Driscoll S.G.
        Decidual arteriopathy in hypertension and diabetes in pregnancy: Immunofluorescence studies.
        Am J Obstet Gynecol. 1981; 141: 773-779
        • Koshy M.
        • Burd L.
        • Wallace D.
        • et al.
        Prophylactic red-cell transfusions in pregnant patients with sickle cell disease.
        N Engl J Med. 1988; 319: 1447-1452
        • Kraus F.T.
        Placental thrombi and related problems.
        Semin Diagn Pathol. 1993; 10: 275-283
        • Kristiansen F.V.
        • Nielsen V.T.
        Intrauterine fetal death and thrombosis of the umbilical vessel.
        Acta Obstet Gynecol Scand. 1985; 64: 331-334
        • Lancy H.J.
        • Kessler C.
        • Kelly W.K.
        • et al.
        Obstetric performance in patients with lupus anticoagulant and/or cardiolipin antibodies.
        Am J Perinatol. 1992; 9: 146-151
        • Lee G.K.
        • Chi J.G.
        • Cha K.S.
        An unusual venous anomaly of the placenta.
        Am J Clin Pathol. 1991; 95: 48-51
        • Lunell N.O.
        • Nylund L.E.
        • Lewander R.
        • et al.
        Uteroplacental blood flow in pre-eclampsia measurements with indium-113m and a computer-linked gamma camera.
        Clin Exper Hyper-Hyper Preg. 1982; B1: 105-117
        • Moscoso G.
        • Jauniaux E.
        • Hustin J.
        Placental vascular anomaly with diffuse mesenchymal stem villous hyperplasia.
        Pathol Res Pract. 1991; 187: 324-328
        • Naeye R.L.
        Maternal floor infarction.
        Hum Pathol. 1985; 16: 823-828
        • Naeye R.L.
        Pregnancy hypertension, placental evidences of low uteroplacental blood flow, and spontaneous premature delivery.
        Hum Pathol. 1989; 20: 441-444
        • Nickel R.E.
        Maternal floor infarction: An unusual cause of intrauterine growth retardation.
        Am J Dis Child. 1988; 142: 1270-1271
        • Pinkerton JHM
        The placental bed arterioles in diabetes.
        Proc R Soc Med. 1963; 56: 1021-1022
        • Powars D.R.
        • Sandhu M.
        • Niland-Weiss J.
        • et al.
        Pregnancy in sickle cell disease.
        Obstet Gynecol. 1986; 67: 217-228
        • Rayne S.C.
        • Kraus F.T.
        Placental thrombi and other vascular lesions. Classification, morphology, and clinical correlations.
        Pathol Res Pract. 1993; 189: 2-17
        • Renaer M.
        • Van de Putte I.
        • Vermylen C.
        Massive feto-maternal hemorrhage as a cause of perinatal mortality and morbidity.
        Eur J Obstet Gynecol Reprod Biol. 1976; 6: 125-140
        • Robb J.A.
        • Benirschke K.
        • Barmeyer R.
        Intrauterine latent herpes simplex virus infection: I. Spontaneous abortion.
        Hum Pathol. 1986; 17: 1196-1209
        • Robertson W.G.
        • Brosens I.
        • Dixon H.G.
        The pathological response of the vessels of the placental bed in hypertensive pregnancy.
        J Path Bact. 1967; 93: 581-592
        • Robertson W.B.
        • Brosens I.
        • Dixon G.
        Uteroplacental vascular pathology.
        Eur J Obstet Gynecol Reprod Biol. 1975; 5: 47-65
        • Robertson W.G.
        Uteroplacental vasculature.
        J Clin Pathol. 1976; 10: 9-17
        • Robertson W.B.
        • Khong T.Y.
        • Brosens I.
        • et al.
        The placental bed biopsy: Review from three European centers.
        Am J Obstet Gynecol. 1986; 155: 401-412
        • Sander C.H.
        Hemorrhagic endovasculitis and hemorrhagic villitis of the placenta.
        Arch Pathol Lab Med. 1980; 104: 371-373
        • Sander C.H.
        • Stevens N.G.
        Hemorrhagic endovasculitis of the placenta: An indepth morphologic appraisal with initial clinical and epidemiologic observations.
        in: Sommers S.C. Rosen P.P. Pathology Annual, vol I. Appleton-Century, Norwalk, CT1984: 37
        • Sander C.H.
        • Kinnane L.
        • Stevens N.G.
        • et al.
        Haemorrhagic endovasculitis of the placenta: A review with clinical correlation.
        Placenta. 1986; 7: 551-574
        • Seligsohn U.
        • Berger A.
        • Abend M.
        • et al.
        Homozygous protein C deficiency manifested by massive venous thrombosis in the newborn.
        N Engl J Med. 1984; 310: 559-562
        • Shen-Schwarz S.
        • Macpherson T.A.
        • Meuller-Heubach E.
        The clinical significance of hemorrhagic endovasculitis of the placenta.
        Am J Obstet Gynecol. 1988; 159: 48-51
        • Sheppard B.L.
        • Bonnar J.
        The ultrastructure of the arterial supply of the human placenta in pregnancy complicated by fetal growth retardation.
        Br J Obstet Gynaecol. 1976; 83: 948-959
        • Sheppard B.L.
        • Bonnar J.
        Uteroplacental arteries and hypertensive pregnancy.
        in: Bonnar J. McGilliray I. Symonds E. Pregnancy Hypertension. MTP Press, Lancaster1980: 213-219
        • Sheridan-Pereira M.
        • Porreco R.P.
        • Hays T.
        • et al.
        Neonatal aortic thrombosis associated with the lupus anticoagulant.
        Obstet Gynecol. 1988; 71: 1016-1018
        • Silver M.M.
        Massive placental infarction due to the lupus anticoagulant [abstract].
        Mod Pathol. 1988; 1: 85A
        • Silver M.M.
        • Yeger H.
        • Lines L.D.
        Hemorrhagic endovasculitis-like lesion induced in placental organ culture.
        Hum Pathol. 1988; 19: 251-256
        • Tenney B.
        • Parker F.
        The placenta in toxemia of pregnancy.
        Am J Obstet Gynecol. 1940; 39: 1000-1005
        • Weinstein L.
        Syndrome of hemolysis, elevated liver enzymes, and low platelet count: A severe consequence of hypertension in pregnancy.
        Am J Obstet Gynecol. 1982; 142: 159-167
        • Wentworth P.
        A placental lesion to account for foetal haemorrhage into the maternal circulation.
        J Obstet Gynaecol Br Commonw. 1964; 71: 379-387
        • Wentworth P.
        Placental infarction and toxemia of pregnancy.
        Am J Obstet Gynecol. 1967; 99: 318-326
        • Williams J.H.
        • Benirschke K.
        Chorionic vessel thrombosis: A possible etiology of neonatal purpura.
        J Reprod Med. 1978; 20: 285-288
        • Wolf P.L.
        • Jones K.L.
        • Longway S.R.
        • et al.
        Prenatal death from acute myocardial infarction and cardiac tamponade due to embolus from the placenta.
        Am Heart J. 1985; 109: 603-605

      Article info

      Identification

      DOI: https://doi.org/10.1016/S0272-2712(18)30321-4

      Copyright

      © 1995 Elsevier Inc. Published by Elsevier Inc. All rights reserved.

      ScienceDirect

      Access this article on ScienceDirect
      We use cookies to help provide and enhance our service and tailor content. To update your cookie settings, please visit the for this site.
      Copyright © 2023 Elsevier Inc. except certain content provided by third parties. The content on this site is intended for healthcare professionals.


      RELX