Advertisement
Research Article| Volume 15, ISSUE 3, P517-543, September 1995

Advances in Endometrial Pathology

      This paper is only available as a PDF. To read, Please Download here.
      This article updates the classification and grading of endometrial carcinoma. Criteria for distinguishing types of endometrial tumors are provided. The current understanding of the pathogenesis of carcinosarcoma is reviewed. The literature on two recently described entities, adenosarcoma and atypical polypoid adenomyoma, is summarized.
      To read this article in full you will need to make a payment

      Purchase one-time access:

      Academic & Personal: 24 hour online accessCorporate R&D Professionals: 24 hour online access
      One-time access price info
      • For academic or personal research use, select 'Academic and Personal'
      • For corporate R&D use, select 'Corporate R&D Professionals'

      Subscribers receive full online access to your subscription and archive of back issues up to and including 2002.

      Content published before 2002 is available via pay-per-view purchase only.

      Subscribe:

      Subscribe to Clinics in Laboratory Medicine
      Already a print subscriber? Claim online access
      Already an online subscriber? Sign in
      Institutional Access: Sign in to ScienceDirect

      References

        • Abeier V.M.
        • Kjorstad K.E.
        Clear cell carcinoma of the endometrium: A histopathological and clinicai study of 97 cases.
        Gynecol Oncol. 1991; 40: 207-217
        • Abeier V.M.
        • Kjorstad K.E.
        • Nesland J.M.
        Undifferentiated carcinoma of the endometrium. A histopathologic and clinical study of 31 cases.
        Cancer. 1991; 68: 98-105
        • Ambros R.A.
        • Ballouk F.
        • Malfetano J.H.
        • et al.
        Significance of papillary (villoglandular) differentiation in endometrioid carcinoma of the uterus.
        Am J Surg Pathol. 1994; 18: 569-575
      1. Ambros RA, Sherman ME, Zahn CM, et al: Endometrial intraepithelial carcinoma: A distinctive lesion specifically associated with tumors displaying serous differentiation. Hum Pathol, in press

        • Andersen W.A.
        • Taylor Jr, P.T.
        • Fechner R.E.
        • et al.
        Endometrial metaplasia associated with endometrial adenocarcinoma.
        Am J Obstet Gynecol. 1987; 157: 597-604
        • Arias-Stella Jr, J.
        • Arias-Velasquez A.
        • Arias-Stella J.
        Normal and abnormal mitoses in the atypical endometrial change associated with chronic tissue effect.
        Am J Surg Pathol. 1994; 18: 694-701
        • Bitterman P.
        • Chun B.
        • Kurman R.J.
        The significance of epithelial differentiation in mixed mesodermal tumors of the uterus. A clinicopathologic and immunohistochemical study.
        Am J Surg Pathol. 1990; 14: 317-328
        • Bokhman J.V.
        Two pathogenetic types of endometrial carcinoma.
        Gynecol Oncol. 1983; 15: 10-17
        • Bur M.E.
        • Perlman C.
        • Edelmann L.
        • et al.
        p53 Expression in neoplasms of the uterine corpus.
        Am J Clin Pathol. 1992; 98: 81-87
        • Chen J.L.
        • Trost D.C.
        • Wilkinson E.J.
        Endometrial papillary adenocarcinomas: Two clinicopathological types.
        Int J Gynecol Pathol. 1985; 4: 279-288
        • Christopherson W.M.
        • Alberhasky R.C.
        • Connelly P.J.
        Carcinoma of the endometrium: I. A clinicopathologic study of clear-cell carcinoma and secretory carcinoma.
        Cancer. 1982; 49: 1511-1523
        • Clement P.B.
        Müllerian adenosarcomas of the uterus with sarcomatous overgrowth. A clinicopathological analysis of 10 cases.
        Am J Surg Pathol. 1989; 13: 28-38
        • Clement P.B.
        • Scully R.E.
        Mullerian adenosarcomas of the uterus with sex cord-like elements. A clinicopathologic analysis of eight cases.
        Am J Clin Pathol. 1989; 91: 664-672
        • Clement P.B.
        • Scully R.E.
        Müllerian adenosarcoma of the uterus: A clinicopathologic analysis of 100 cases with a review of the literature.
        Hum Pathol. 1990; 21: 363-381
        • Creasman W.T.
        New gynecologic cancer staging.
        Obstet Gynecol. 1990; 75: 287-288
        • de Brito P.A.
        • Silverberg S.G.
        • Orenstein J.M.
        Carcinosarcoma (malignant mixed müllerian (mesodermal) tumor) of the female genital tract: Immunohistochemical and ultrastructural analysis of 28 cases.
        Hum Pathol. 1993; 24: 132-142
        • Deligdisch L.
        • Holinka C.F.
        Endometrial carcinoma: Two diseases?.
        Cancer Detect Prev. 1987; 10: 237-246
        • Emoto M.
        • Iwasaki H.
        • Kikuchi M.
        • et al.
        Characteristics of cloned cells of mixed müllerian tumor of the human uterus. Carcinoma cells showing myogenic differentiation in vitro.
        Cancer. 1993; 71: 3065-3075
        • Gersell D.J.
        Endometrial papillary syncytial change. Another perspective.
        Am J Clin Pathol. 1993; 99: 656-657
        • Gorai I.
        • Doi C.
        • Minaguchi H.
        Establishment and characterization of carcinosarcoma cell line of the human uterus.
        Cancer. 1993; 71: 775-786
        • Hendrickson M.R.
        • Kempson R.L.
        Endometrial epithelial metaplasias: Proliferations frequently misdiagnosed as adenocarcinoma. Report of 89 cases and proposed classification.
        Am J Surg Pathol. 1980; 4: 525-542
        • Hendrickson M.R.
        • Kempson R.L.
        Ciliated carcinoma-a variant of endometrial adenocarcinoma: A report of 10 cases.
        Int J Gynecol Pathol. 1983; 2: 1-12
        • Hendrickson M.
        • Ross J.
        • Eifel P.
        • et al.
        Uterine papillary serous carcinoma: A highly malignant form of endometrial adenocarcinoma.
        Am J Surg Pathol. 1982; 6: 93-108
        • Huntsman D.G.
        • Clement P.B.
        • Gilks C.B.
        • et al.
        Small-cell carcinoma of the endometrium. A clinicopathological study of sixteen cases.
        Am J Surg Pathol. 1994; 18: 364-375
        • Kaku T.
        • Silverberg S.G.
        • Major F.J.
        • et al.
        Adenosarcoma of the uterus: A Gynecologic Oncology Group clinicopathologic study of 31 cases.
        Int J Gynecol Pathol. 1992; 11: 75-88
        • Kaku T.
        • Tsukamoto N.
        • Tsuruchi N.
        • et al.
        Endometrial metaplasia associated with endometrial carcinoma.
        Obstet Gynecol. 1992; 80: 812-816
        • Kohler M.F.
        • Nishii H.
        • Humphrey P.A.
        • et al.
        Mutation of the p53 tumor-suppressor gene is not a feature of endometrial hyperplasias.
        Am J Obstet Gynecol. 1993; 169: 690-694
        • Kurman R.J.
        Blaustein’s Pathology of the Female Genital Tract. ed 4. Springer-Verlag, New York1994: 439-486
        • Kurman R.J.
        • Norris H.J.
        Evaluation of criteria for distinguishing atypical endometrial hyperplasia from well-differentiated carcinoma.
        Cancer. 1982; 49: 2547-2559
        • Lee K.R.
        • Belinson J.L.
        Recurrence in noninvasive endometrial carcinoma. Relationship to uterine papillary serous carcinoma.
        Am J Surg Pathol. 1991; 15: 965-973
        • Mazur M.T.
        Atypical polypoid adenomyomas of the endometrium.
        Am J Surg Pathol. 1981; 5: 473-482
        • Melhem M.F.
        • Tobon H.
        Mucinous adenocarcinoma of the endometrium: A clinicopathologic review of 18 cases.
        Int J Gynecol Pathol. 1987; 6: 347-355
        • Ross J.C.
        • Kempson R.L.
        • Eifel P.J.
        • et al.
        Primary mucinous adenocarcinoma of the endometrium. A clinicopathologic and histochemical study.
        Am J Surg Pathol. 1983; 7: 715-729
        • Scully R.E.
        • Poulson H.
        • Sobin L.H.
        International Histological Classification and Histologic Typing of Female Genital Tract Tumors. Springer-Verlag, Berlin1994
        • Sherman M.E.
        • Bitterman P.
        • Rosenshein N.B.
        • et al.
        Uterine serous carcinoma. A morphologically diverse neoplasm with unifying clinicopathologic features.
        Am J Surg Pathol. 1992; 16: 600-610
      2. Sherman ME, Bur M, Kurman RJ: A dualistic model of endometrial carcinogenesis. Immunohistochemical localization of p53 in endometrioid carcinoma, serous carcinoma and malignant mixed mesodermal tumors. Hum Pathol, in press

        • Silva E.G.
        • Jenkins R.
        Serous carcinoma in endometrial polyps.
        Mod Pathol. 1990; 3: 120-128
        • Silverberg S.G.
        • Bolin M.G.
        • DeGiorgi L.S.
        Adenoacanthoma and mixed adenosquamous carcinoma of the endometrium. A clinicopathologic study.
        Cancer. 1972; 30: 1307-1314
        • Silverberg S.G.
        • Kurman R.J.
        Tumor of the Uterine Corpus and Gestational Trophoblastic Disease. Atlas of Tumor Pathology (Third Series, Fascicle 3). Armed Forces Institute of Pathology, Washington, DC1992
        • Silverberg S.G.
        • Major F.J.
        • Blessing J.A.
        • et al.
        Carcinosarcoma (malignant mixed mesodermal tumor) of the uterus. A Gynecologic Oncology Group pathologic study of 203 cases.
        Int J Gynecol Pathol. 1990; 9: 1-19
        • Tobon H.
        • Watkins G.J.
        Secretory adenocarcinoma of the endometrium.
        Int J Gynecol Pathol. 1985; 4: 328-335
        • Young R.H.
        • Treger T.
        • Scully R.E.
        Atypical polypoid adenomyoma of the uterus. A report of 27 cases.
        Am J Clin Pathol. 1986; 86: 139-145
        • Zaino R.J.
        • Kurman R.
        • Herbold D.
        • et al.
        The significance of squamous differentiation of endometrial carcinoma. Data from a Gynecologic Oncology Group study.
        Cancer. 1991; 68: 2293-2302
        • Zaloudek C.J.
        • Norris H.J.
        Adenofibroma and adenosarcoma of the uterus: A dinicopathologic study of 35 cases.
        Cancer. 1981; 48: 354-366
        • Zaman S.S.
        • Mazur M.T.
        Endometrial papillary syncytial change. A nonspecific alteration associated with active breakdown.
        Am J Clin Pathol. 1993; 99: 741-745