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Research Article| Volume 16, ISSUE 1, P73-88, March 1996

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DNA Analysis in the Study of Fungal Infections in the Immunocompromised Host

  • Marcus J. Zervos
    Correspondence
    Address reprint requests to: Marcus J. Zervos, MD, William Beaumont Hospital, 3601 West Thirteen Mile Road, Royal Oak, MI 48073
    Affiliations
    From the Division of Infectious Diseases, Departments of Medicine and Clinical Pathology, William Beaumont Hospital, Royal Oak, Michigan

    Wayne State University School of Medicine, Detroit, Michigan
    Search for articles by this author
  • Jose A. Vazquez
    Affiliations
    Wayne State University School of Medicine, Detroit, Michigan
    Search for articles by this author
DOI:https://doi.org/10.1016/S0272-2712(18)30288-9
DNA Analysis in the Study of Fungal Infections in the Immunocompromised Host
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      Fungal infections, most of which are caused by the Candida species, are an increasing problem in the immunocompromised host. The clinical manifestations of Candida infections include disseminated candidiasis, oral and esophageal infections, focal hepatic infections, peritoneal urinary tract infections, and wound infections. DNA methods, which include pulse field electrophoresis and restriction enzyme analysis of genomic DNA, have been used to increase understanding of the epidemiology of these infections. These techniques have shown that most Candida infections are endogenous or acquired from one’s own flora. Recent outbreaks have provided evidence for exogenous acquisition of some isolates. Better methods for differentiation of colonization versus infection and identifying infection in the absence of positive cultures are under investigation.
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      DOI: https://doi.org/10.1016/S0272-2712(18)30288-9

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      © 1996 Elsevier Inc. Published by Elsevier Inc. All rights reserved.

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