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Research Article| Volume 16, ISSUE 1, P23-47, March 1996

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Bcl-2 Gene Rearrangements in Lymphoid Malignancies

  • Domnita Crisan
    Correspondence
    Address reprint requests to: Domnita Crisan, MD, PhD, Department of Clinical Pathology, William Beaumont Hospital, 3601 West Thirteen Mile Road, Royal Oak, MI 48073–6769
    Affiliations
    From the Molecular Pathology Laboratory, Department of Clinical Pathology, William Beaumont Hospital, Royal Oak, Michigan
    Search for articles by this author
DOI:https://doi.org/10.1016/S0272-2712(18)30285-3
Bcl-2 Gene Rearrangements in Lymphoid Malignancies
Previous ArticleClinical Use of B- and T-Cell Gene Rearrangement Analysis in Hematopoietic Disorders
Next ArticleThe Role of Molecular Diagnostics in the Clinical Microbiology Laboratory
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      Chromosomal translocations consistently associated with lymphoid malignancies result in gene rearrangements and activation of cellular oncogenes. The bcl-2 gene rearrangement is one of the most thoroughly studied and clinically useful in the diagnosis and monitoring of patients with lymphoma. The molecular analysis of this gene rearrangement has led to the discovery of the first member of a new class of oncogenes, the regulators of programmed cell death.
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      Article info

      Footnotes

      This work was supported by the Department of Clinical Pathology, William Beaumont Hospital, Royal Oak, Michigan.

      Identification

      DOI: https://doi.org/10.1016/S0272-2712(18)30285-3

      Copyright

      © 1996 Elsevier Inc. Published by Elsevier Inc. All rights reserved.

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