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The clinical application of B- and T-cell gene rearrangement analysis is discussed
relative to diagnostic problems in specific lymphoprolifer ative disorders. This article
reviews the use of the Southern blot hybridization technique for B- and T-cell gene
rearrangement detection in the analysis of various hematopoietic lesions. Several
case studies are presented and analyzed.
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© 1996 Elsevier Inc. Published by Elsevier Inc. All rights reserved.