Research Article| Volume 16, ISSUE 1, P1-21, March 1996

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Clinical Use of B- and T-Cell Gene Rearrangement Analysis in Hematopoietic Disorders

  • John R. Krause
    Address reprint requests to: John R. Krause, MD, Department of Clinical Pathology, Tulane Medical Center, 1415 Tulane Avenue, New Orleans, LA 70112
    From the Department of Clinical Pathology, Tulane Medical Center, New Orleans, Louisiana
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      The clinical application of B- and T-cell gene rearrangement analysis is discussed relative to diagnostic problems in specific lymphoprolifer ative disorders. This article reviews the use of the Southern blot hybridization technique for B- and T-cell gene rearrangement detection in the analysis of various hematopoietic lesions. Several case studies are presented and analyzed.
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