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Research Article| Volume 16, ISSUE 2, P407-428, June 1996

Molecular Variants of Hepatitis B Virus

  • William F. Carman
    Correspondence
    Address reprint requests to: William F. Carman, MBBCh, MMed, MRCPath, Institute of Virology, University of Glasgow, Church Street, Glasgow, Gil 5JR, Scotland, United Kingdom
    Affiliations
    From the Institute of Virology, University of Glasgow, Glasgow, Scotland, United Kingdom
    Search for articles by this author
DOI:https://doi.org/10.1016/S0272-2712(18)30277-4
Molecular Variants of Hepatitis B Virus
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      Variation in the genome of hepatitis B virus has been associated with a number of clinical parameters, but there is a paucity of functional data to show a causal relationship. For example, variants of the core and X genes have been linked with the pathogenesis of chronic hepatitis, viral replication efficiency, and serologically negative infections, among other observations. Variants of the surface antigen are linked with infection after vaccination, infection of liver grafts in patients undergoing immunotherapy, and samples that react poorly in diagnostic assays.
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      DOI: https://doi.org/10.1016/S0272-2712(18)30277-4

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