Research Article| Volume 16, ISSUE 2, P377-394, June 1996

Alcohol and Other Chemicals in the Development of Hepatocellular Carcinoma

  • Farber Emmanuel
    Address reprint requests to: Emmanuel Färber, MD, PhD, Department of Pathology, Anatomy, and Cell Biology, Thomas Jefferson University, 212B Jefferson Alumni Hall, 1020 Locust Street, Philadelphia, PA 19107–6799
    From the Department of Pathology, Anatomy, and Cell Biology, Thomas Jefferson University, Philadelphia, Pennsylvania
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      The possible roles of alcohol (ethanol) as a carcinogen and as a modulator of the carcinogenic process are reviewed. The effects of alcohol are compared with those of well-known genotoxic and nongenotoxic or epigenetic carcinogens in their roles in the genesis of hepatocellular carcinomas. Also, the effects of alcohol are compared with those of known promoting agents for the liver. In addition, the possible roles of alcohol in the genesis of the potential precancerous liver lesions, in cirrhosis, and in the modulation of cancer induction with the known carcinogenic influences, hepatitis B and C viruses, are analyzed. The possible role of alcohol in the modulation of liver cell membrane lesions in the development of liver cell cancer is explored.
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