Research Article| Volume 16, ISSUE 2, P361-375, June 1996

Hepatic Fibrogenesis

  • Bernard H. Davis
    Address reprint requests to: Bernard H. Davis, MD, The University of Chicago, Gastroenterology Section, Department of Medicine, 5841 South Maryland Avenue, MC 4076, Chicago, IL 60637
    From the Gastroenterology Section, Department of Medicine, The University of Chicago, Chicago, Illinois
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  • Thomas F. Kresina
    Liver, Biliary and Pancreas Disease Programs, Division of Digestive Diseases and Nutrition, National Institutes of Health, Bethesda, Maryland
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      This paper is only available as a PDF. To read, Please Download here.
      Hepatic fibrogenesis may be the end result of chronic alcohol abuse, viral or parasitic infection, heavy metal overload, bile duct obstruction, or autoimmune disease. The sinusoidal hepatic stellate cell (or Ito cell or lipocyte) is the major effector cell that proliferates during fibrogenesis and produces abnormal amounts of extracellular matrix proteins as well as matrix-degrading enzymes. This article summarizes the known matrix proteins and the putative regulatory cytokines, cytoplasmic kinases, and transcription factors involved in this process.
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