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Research Article| Volume 16, ISSUE 2, P361-375, June 1996

Hepatic Fibrogenesis

  • Bernard H. Davis
    Correspondence
    Address reprint requests to: Bernard H. Davis, MD, The University of Chicago, Gastroenterology Section, Department of Medicine, 5841 South Maryland Avenue, MC 4076, Chicago, IL 60637
    Affiliations
    From the Gastroenterology Section, Department of Medicine, The University of Chicago, Chicago, Illinois
    Search for articles by this author
  • Thomas F. Kresina
    Affiliations
    Liver, Biliary and Pancreas Disease Programs, Division of Digestive Diseases and Nutrition, National Institutes of Health, Bethesda, Maryland
    Search for articles by this author
DOI:https://doi.org/10.1016/S0272-2712(18)30274-9
Hepatic Fibrogenesis
Previous ArticleLiver Regeneration in Health and Disease
Next ArticleAlcohol and Other Chemicals in the Development of Hepatocellular Carcinoma
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      Hepatic fibrogenesis may be the end result of chronic alcohol abuse, viral or parasitic infection, heavy metal overload, bile duct obstruction, or autoimmune disease. The sinusoidal hepatic stellate cell (or Ito cell or lipocyte) is the major effector cell that proliferates during fibrogenesis and produces abnormal amounts of extracellular matrix proteins as well as matrix-degrading enzymes. This article summarizes the known matrix proteins and the putative regulatory cytokines, cytoplasmic kinases, and transcription factors involved in this process.
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      DOI: https://doi.org/10.1016/S0272-2712(18)30274-9

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      © 1996 Elsevier Inc. Published by Elsevier Inc. All rights reserved.

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