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Research Article| Volume 16, ISSUE 2, P307-324, June 1996

Hepatocellular Injury in Hepatitis B and C Virus Infections

  • Mark A. Feitelson
    Correspondence
    Address reprint requests to: Mark A. Feitelson, PhD, Department of Pathology, Anatomy, and Cell Biology, 219 Jefferson Alumni Hall, Thomas Jefferson University, 1020 Locust Street, Philadelphia, PA 19107-6799
    Affiliations
    From the Department of Pathology, Anatomy, and Cell Biology, Thomas Jefferson University, Philadelphia, Pennsylvania
    Search for articles by this author
DOI:https://doi.org/10.1016/S0272-2712(18)30271-3
Hepatocellular Injury in Hepatitis B and C Virus Infections
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      Most of the liver cell injury in hepatitis B and C infections is likely to be immune-media ted. Variation in the pathogenesis of these infections likely is contributed by a variety of host and virus factors. Host factors include the human leukocyte antigen (HLA) haplotype as well as the ability of the host to both recognize antigen on virus-infected cells and to receive the appropriate costimulatory signals in a timely fashion during infection. Virus factors include the genetic variation, direct cytopathic effects, and the alteration of infected hepatocytes to cytotoxic cytokines. The lack of suitable tissue culture systems and animal models limits the ability to understand the pathogenesis fully but provides challenges for their future development so that the basis for liver cell damage can be elucidated and approaches for therapeutic intervention can be achieved.
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      Article info

      Footnotes

      This work was supported by grants CA48656 and CA66971 from the National Institutes of Health.

      Identification

      DOI: https://doi.org/10.1016/S0272-2712(18)30271-3

      Copyright

      © 1996 Elsevier Inc. Published by Elsevier Inc. All rights reserved.

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