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Research Article| Volume 16, ISSUE 2, P289-306, June 1996

Ethanol and Hepatocellular Injury

  • Samuel W. French
    Correspondence
    Address reprint requests to: Samuel W. French, MD, Division of Anatomic Pathology, Harbor–UCLA Medical Center, 1000 West Carson Street, Torrance, CA 90509
    Affiliations
    From the Division of Anatomic Pathology, Harbor–UCLA Medical Center, Torrance, California
    Search for articles by this author
DOI:https://doi.org/10.1016/S0272-2712(18)30270-1
Ethanol and Hepatocellular Injury
Previous ArticleInteractions Between Alcohol and Hepatitis Viruses in the Liver
Next ArticleHepatocellular Injury in Hepatitis B and C Virus Infections
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      Hepatocellular injury that results from chronic alcohol abuse may be a consequence of (1) augmented viremia in hepatitis C virus; (2) the carcinogenic effect of DNA, which results from the combination of alcohol-induced CYP2E1 and ingestion of low levels of carcinogenic compounds or choline deficiency; (3) differential proliferation of hepatocytes versus nonparenchymal cells during injury, regeneration, and repair; (4) alteration of the regenerative response of hepatocytes in response to agonists, which stimulate the cell cycle through membrane signal transduction-nuclear pathways; (5) Kupffer cell activation by endotoxin, which generates cytokines that signal hepatocellular programmed cell death (apoptosis) through signal transduction mechanisms; or (6) dietary and immune mechanisms (i.e., formation of neoantigens).
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      DOI: https://doi.org/10.1016/S0272-2712(18)30270-1

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