Research Article| Volume 17, ISSUE 3, P595-604, September 1997

Auto Antibodies Against Oxidized LDL: A Potential Marker for Atherosclerosis

  • James T. Wu
    Address reprint requests to James T. Wu, PhD, ARUP, 500 Chipeta Way, Salt Lake City, UT 84108
    From the Departments of Pathology (JTW, LLW)

    ARUP (JTW, LLW), University of Utah Medical Science Complex, Salt Lake City, Utah
    Search for articles by this author
  • Lily L. Wu
    From the Departments of Pathology (JTW, LLW)

    Internal Medicine (LLW)

    ARUP (JTW, LLW), University of Utah Medical Science Complex, Salt Lake City, Utah
    Search for articles by this author
      This paper is only available as a PDF. To read, Please Download here.
      Oxidized LDL, not the native LDL, promotes atherosclerosis. However, ox-LDL is usually undetectable in the blood circulation. Autoantibodies against ox-LDL (γ ox-LDL), on the other hand, are not only measurable in the blood but may also reflect the extent of in vivo oxidation of native LDL and provide any early sign of risk for atherosclerosis. Current assay for 7 ox-LDL needs improvement. Routine clinical application of this assay has to wait until all parameters of this assay are defined and characterized.
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