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Research Article| Volume 17, ISSUE 3, P445-464, September 1997

Serodiagnosis of Celiac Disease

  • Joseph A. Murray
    Correspondence
    Address reprint requests to Joseph A. Murray, MD, Department of Internal Medicine, Division of Gastroenterology-Hepatology, 4670A JCP, University of Iowa, 200 Hawkins Drive, Iowa City, IA 52242
    Affiliations
    From the Department of Medicine, Division of Gastroenterology-Hepatology, University of Iowa, Iowa City, Iowa
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      The detection rate of celiac disease greatly underestimates its prevalence. This is the result of lack of awareness of the many manifestations of the condition and the requirement for at least one small intestinal biopsy for diagnosis. The advent of effective serologic tests for the condition heralds a new era of non-invasive testing. The clinical utility and acceptance of these tests is limited by a lack of standardization of both the techniques used and variability of reference ranges quoted.
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