Advertisement
Research Article| Volume 17, ISSUE 3, P379-393, September 1997

Download started.

Ok

Role of Autoantibody Tests in the Diagnostic Evaluation of Neuropsychiatric Systemic Lupus Erythematosus

  • Robert M. Nakamura
    Correspondence
    Address reprint requests to Robert M. Nakamura, MD, Department of Pathology, Scripps Clinic and Research Foundation, 10666 North Torrey Pines Road, La Jolla, CA 92037
    Affiliations
    From the Department of Pathology, Scripps Clinic and Research Foundation, La Jolla, California
    Search for articles by this author
DOI:https://doi.org/10.1016/S0272-2712(18)30202-6
Role of Autoantibody Tests in the Diagnostic Evaluation of Neuropsychiatric Systemic Lupus Erythematosus
Previous ArticleThe Clinical Utility of Antihistone Antibodies
Next ArticleAntiphospholipid Antibodies:
      This paper is only available as a PDF. To read, Please Download here.
      Neuropsychiatric Systemic Lupus Erythematosus (NPSLE) can be defined as a significant and unequivical change in the baseline neurologic and psychiatric function identified by history and physical examination. NPSLE can involve the centralnervous system and/or the peripheral.autonomic nervous system. This article reviews the clinical manifestations, pathology, and immunopathogenesis of NPSLE. The use and importance of diagnostic procedures including autoantibody assays in the evaluation of NPSLE are discussed.
      To read this article in full you will need to make a payment

      Purchase one-time access:

      Academic & Personal: 24 hour online accessCorporate R&D Professionals: 24 hour online access
      One-time access price info
      • For academic or personal research use, select 'Academic and Personal'
      • For corporate R&D use, select 'Corporate R&D Professionals'

      Subscribers receive full online access to your subscription and archive of back issues up to and including 2002.

      Content published before 2002 is available via pay-per-view purchase only.

      Subscribe:

      Subscribe to Clinics in Laboratory Medicine
      Already a print subscriber? Claim online access
      Already an online subscriber? Sign in
      Register: Create an account
      Institutional Access: Sign in to ScienceDirect

      References

        • Barr W.G.
        • Merchut M.P.
        Systemic lupus erythematosus with central nervous system involvement.
        Psychiatr Clin North Am. 1992; 15: 439-454
        • Bennahum D.A.
        • Messner R.P.
        Recent observations on central nervous system lupus erythematosus.
        Semin Arthritis Rheum. 1975; 4: 253-266
        • Bluestein H.G.
        The central nervous system in systemic lupus erythematosus.
        in: Lahita R.G. Systemic Lupus Erythematosus. ed 2. Churchill Livingstone, New York1992: 639-655
        • Bluestein H.G.
        Neurocytotoxic antibodies in the serum of patients with systemic lupus erythematosus.
        Proc Natl Acad Sei USA. 1978; 75: 3965-3970
        • Bluestein H.G.
        • Zvaifler N.J.
        Brain-reactive lymphocytotoxic antibodies in the serum of patients with systemic lupus erythematosus.
        J Clin Invest. 1976; 57: 509-516
        • Bluestein H.G.
        • Williams G.W.
        • Steinberg A.D.
        Cerebral spinal fluid antibodies to neuronal cells: Association with neuropsychiatric manifestations of systemic lupus erythematosus.
        Am J Med. 1981; 70: 240-246
        • Bonfa E.
        • Golombek S.J.
        • Kaufman L.D.
        • et al.
        Association between lupus psychosis and anti-ribosomal P protein antibodies.
        N Engl J Med. 1987; 317: 265-271
        • Brey R.L.
        • Gharavi A.E.
        • Lockshin M.D.
        Neurologic complications of antiphospholipid antibodies.
        Rheum Dis Clin North Am. 1993; 19: 833-850
        • Caponi L.
        • Pegoraro S.
        • Di Bartolo V.
        • et al.
        Autoantibodies directed against ribosomal P proteins: Use of a multiple antigen peptide as the coating agent in ELISA.
        J Immunol Methods. 1995; 179: 193-202
        • Denburg J.A.
        • Carbotte R.M.
        • Denburg S.D.
        Neuronal antibodies and cognitive function in systemic lupus erythematosus.
        Neurology. 1987; 37: 464-467
        • Denburg S.D.
        • Behmann S.A.
        • Carbotte R.M.
        • et al.
        Lymphocyte antigens in neuropsychiatric systemic lupus erythematosus.
        Arthritis Rheum. 1994; 37: 369-375
        • Denburg S.D.
        • Denburg J.A.
        • Carbotte R.M.
        • et al.
        Cognitive deficits in systemic lupus erythematosus.
        Rheum Dis Clin North Am. 1993; 19: 815-831
        • Elkon K.
        • Skelly S.
        • Pamassa A.
        • et al.
        Identification and chemical synthesis of a ribosomal protein antigenic determinant in systemic lupus erythematosus.
        Proc Natl Acad Sei USA. 1986; 83: 7419-7423
        • Elkon K.B.
        • Bonfa E.
        • Brot N.
        Antiribosomal antibodies in systemic lupus erythematosus.
        Rheum Dis Clin North Am. 1992; 18: 377-390
        • Elkon K.B.
        • Bonfa E.
        • Weissbach H.
        • et al.
        Antiribosomal antibodies in SLE, infection, and following deliberate immunization.
        Adv Exp Med Biol. 1994; 347: 81-92
        • Ellis S.G.
        • Verity M.A.
        Central nervous system involvement in systemic lupus erythematosus: A review of neuropathologic findings in 57 cases, 1955-1977.
        Semin Arthritis Rheum. 1979; 8: 212-221
        • Francoeur A.-M.
        • Peebles C.L.
        • Heckman K.J.
        • et al.
        Identification of ribosomal protein autoantigens.
        J Immunol. 1985; 135: 2378-2384
        • Futrell N.
        • Schultz L.R.
        • Millikan C.
        Central nervous system disease in patients with systemic lupus erythematosus.
        Neurology. 1992; 42: 1649-1657
        • Hall R.C.
        • Stickney S.K.
        • Gardner E.R.
        Psychiatric symptoms in patients with systemic lupus erythematosus.
        Psychosomatics. 1981; 22: 15-24
        • How A.
        • Dent P.B.
        • Liao S.-K.
        • et al.
        Antineuronal antibodies in neuropsychiatric systemic lupus erythematosus.
        Arthritis Rheum. 1985; 28: 789-795
        • Johnson R.T.
        • Richardson E.P.
        The neurological manifestations of systemic lupus erythematosus.
        Medicine. 1968; 47: 337-369
        • Kaell A.T.
        • Shetty M.
        • Lee B.P.
        • et al.
        The diversity of neurologic events in SLE.
        Arch Neurol. 1986; 43: 273-276
        • Kassan S.S.
        • Lockshin M.D.
        Central nervous system lupus erythematosus-the need for classification.
        Arthritis Rheum. 1979; 22: 1382-1385
        • Koren E.
        • Reichlin M.W.
        • Koscec M.
        • et al.
        Autoantibodies to the ribosomal P proteins react with a plasma membrane related target on human cells.
        J Clin Invest. 1992; 89: 1236-1241
        • Kovacs J.A.
        • Urowitz M.B.
        • Gladman D.D.
        Dilemmas in neuropsychiatric lupus.
        Rheum Dis Clin North Am. 1993; 19: 795-814
        • Lahita R.G.
        Systemic Lupus Erythematosus.
        ed 2. New York, Churchill Livingstone1992
        • Long A.A.
        • Denburg S.D.
        • Carbotte R.M.
        • et al.
        Serum lymphocytotoxic antibodies and neurocognitive function in systemic lupus erythematosus.
        Ann Rheum Dis. 1990; 49: 249-253
        • McCune W.J.
        • Globus J.
        Neuropsychiatric lupus.
        Rheum Dis Clin North Am. 1988; 14: 149-167
        • Moore P.
        • Lisak R.P.
        Systemic lupus erythematosus: Immunopathogenesis of neurologic dysfunction.
        Springer Semin Immunopathol. 1995; 17: 43-60
        • Nakamura R.M.
        Clinical and laboratory evaluation of systemic rheumatic diseases.
        in: Henry J.B. Clinical Diagnosis and Management by Laboratory Methods. ed 19. WB Saunders, Philadelphia1996: 1013-1024
        • Nakamura R.M.
        • Bylund D.J.
        Contemporary concepts for clinical and laboratory evaluation of systemic lupus erythematosus and "lupus-like" syndromes.
        J Clin Lab Anal. 1994; 8: 347-359
        • Ochola J.
        • Hussain M.
        • Khamashta M.
        • et al.
        Short communication.
        Detection of brain- reactive autoantibodies in the sera of patients with systemic lupus erythematosus and cerebral involvement. J Immunol Methods. 1995; 185: 259-261
        • O'Conner J.F.
        • Miescher D.M.
        Central nervous system involvement in systemic lupus erythematosus. A study of 150 cases.
        Arch Neurol. 1966; 14: 157-164
        • Papero P.H.
        • Bluestein H.G.
        • White P.
        • et al.
        Neuropsychologic deficits and antineuronal antibodies in pediatric systemic lupus erythematosus.
        Clin Exp Rheum. 1990; 8: 417-424
        • Robbins M.L.
        • Komguth S.E.
        • Bell C.L.
        • et al.
        Antineurofilament antibody evaluation in neuropsychiatric systemic lupus erythematosus.
        Combination with anticardiolipin antibody assay and magnetic resonance imaging. Arthritis Rheum. 1988; 31: 623-631
        • Schneebaum A.
        • Singleton J.
        • West S.
        • et al.
        Association of psychiatric manifestations with antibodies to ribosomal P proteins in systemic lupus erythematosus.
        Am J Med. 1991; 90: 45-62
        • Singer J.
        • Denburg J.A.
        Ad hoc neuropsychiatric lupus workshop group: Diagnostic criteria for neuropsychiatric systemic lupus erythematosus: The results of a consensus meeting (workshop report).
        J Rheumatol. 1990; 17: 1397-1402
        • Spezialetti R.
        • Bluestein H.G.
        • Peter J.B.
        • et al.
        Neuropsychiatric disease in Sjogren's syndrome: Anti-ribosomal P and anti-neuronal antibodies.
        Am J Med. 1993; 95: 153
        • Stafford H.A.
        • Anderson C.J.
        • Reichlin M.
        Unmasking of anti-ribosomal P autoantibodies in healthy individuals.
        J Immunol. 1995; 155: 2754-2761
        • Tan E.M.
        • Cohen A.S.
        • Fries J.F.
        • et al.
        The 1982 revised criteria for the classification of systemic lupus erythematosus.
        Arthritis Rheum. 1982; 25: 1271-1277
        • Teh L.S.
        • Isenberg D.A.
        Antiribosomal P protein antibodies in systemic lupus erythematosus.
        A reappraisal. Arthritis Rheum. 1994; 37: 307-315
        • Toubi E.
        • Khamashta M.A.
        • Panarra A.
        • et al.
        Association of antiphospholipid antibodies with central nervous system disease in systemic lupus erythematosus.
        Am J Med. 1995; 99: 397-401
        • Urowitz M.B.
        • Gladman D.D.
        • Tozman E.C.S.
        • et al.
        The lupus activity criteria count (LACC).
        J Rheumatol. 1984; 11: 783-787
        • West S.G.
        Neuropsychiatric lupus.
        Rheum Dis Clin North Am. 1994; 20: 129-158
        • West S.G.
        • Emlen W.
        • Wener M.H.
        • et al.
        Neuropsychiatric lupus erythematosus: A 10- year prospective study on the value of diagnostic tests.
        Am J Med. 1995; 99: 153-163
        • Yoshio T.
        • Masuyama J.-I.
        • Ikeda M.
        • et al.
        Quantification of antiribosomal PO protein antibodies by ELISA with recombinant PO fusion protein and their association with central nervous system disease in systemic lupus erythematosus.
        J Rheumatol. 1995; 22: 1681-1687
        • Zvaifler N.
        Neurologic manifestations.
        in: Schur P. The Clinical Management of Systemic Lupus Erythematosus. Grune & Stratton, New York1983: 167-188

      Article info

      Identification

      DOI: https://doi.org/10.1016/S0272-2712(18)30202-6

      Copyright

      © 1997 Elsevier Inc. Published by Elsevier Inc. All rights reserved.

      ScienceDirect

      Access this article on ScienceDirect

      The content on this site is intended for healthcare professionals.


      We use cookies to help provide and enhance our service and tailor content. To update your cookie settings, please visit the Cookie Preference Center for this site.
      Copyright © 2023 Elsevier Inc. except certain content provided by third parties.


      RELX